|
| Status |
Public on Feb 09, 2009 |
| Title |
Gene expression analysis of delg_mut versus Df_plus control |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by array
|
| Summary |
Nuclear transcription factors drive mitochondrial mass by regulating the expression of genes encoding mitochondrial proteins. Among these factors, nuclear respiratory factor 2 (NRF-2/GABP) has been proposed to be critical for mitochondrial mass in mammalian cells, yet there is little genetic evidence to support this function in vivo. Here, we show that mutants of the Drosophila melanogaster NRF-2alpha/GABPalpha homologue Delg (CG6338) have reduced expression of multiple genes encoding mitochondrial proteins, leading to reduced mitochondrial mass.
|
| |
|
| Overall design |
Six samples were analyzed in total: three biological replicates of the control (Df_plus) and three biological replicates of the mutant (Df_delg).
|
| |
|
| Contributor(s) |
Baltzer C, Tiefenboeck SK, Marti M, Frei C |
| Citation(s) |
19742324 |
| Submission date |
Dec 19, 2008 |
| Last update date |
Aug 28, 2018 |
| Contact name |
Claudia Baltzer |
| E-mail(s) |
claudia.baltzer@cell.biol.ethz.ch
|
| Organization name |
ETH Zürich
|
| Department |
Cell biology
|
| Lab |
Frei
|
| Street address |
Schafmattstrasse 18
|
| City |
Zurich |
| State/province |
Zurich |
| ZIP/Postal code |
CH-8093 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL1322 |
[Drosophila_2] Affymetrix Drosophila Genome 2.0 Array |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA112423 |
Less...
More...