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| Status |
Public on Oct 06, 2008 |
| Title |
Heterogeneous in vitro effects of doxorubicin on gene expression in primary human liposarcoma cultures |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Doxorubicin is considered one of the most potent established chemotherapeutics in the treatment of liposarcoma; however, the response rates usually below 30%, are still disappointing. This study was performed to identify gene expression changes in liposarcoma after doxorubicin treatment. Cells of 19 primary human liposarcoma were harvested intraoperatively and brought into cell culture. Cells were incubated with doxorubicin for 24 h, RNA was isolated and differential gene expression was analysed by the microarray technique.
We used microarrays to detail the global gene expression changes following doxorubicin treatment of primary liposarcoma cell cultures
Keywords: response to chemotherapeutic agent
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| |
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| Overall design |
We compared untreated primary cell cultures obtained from liposarcoma treated with doxorubicin treated cultures to determine global gene expression changes by microarray analysis
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| |
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| Contributor(s) |
Klein-Hitpass L, Daigeler A |
| Citation(s) |
18959781 |
| Submission date |
Sep 29, 2008 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Ludger Klein-Hitpass |
| E-mail(s) |
ludger.klein-hitpass@uni-essen.de
|
| Phone |
+49 201 723 85552
|
| Organization name |
Institut fuer Zellbiologie
|
| Department |
Universitaetsklinikum
|
| Lab |
BioChip Lab
|
| Street address |
Virchowstr. 173
|
| City |
Essen |
| ZIP/Postal code |
D-45122 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
|
| Samples (38)
|
|
| Relations |
| BioProject |
PRJNA112581 |
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