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| Status |
Public on Dec 31, 2019 |
| Title |
Late recurrence-associated long non-coding RNA NR2F1 antisense 1 (NR2F1-AS1) II |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Long non-coding RNA NR2F1 antisense RNA1 (lncRNA NR2F1-AS1) was identified as the main candidate associated to late recurrence in ER-positive breast cancer clinical samples. Gain-of-function of NR2F1-AS1 induced the expression of dormancy-inducers BMP4 and DEC2, and upregulated pluripotency markers NANOG and OCT4. Representative pathways entailed to metastatic events such as HER2/Neu, hypoxia, EMT and inflammatory-response were also found enriched.
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| Overall design |
We identified the lncRNA NR2F1 antisense RNA1 (NR2F1-AS1) as the main candidate associated to late recurrence in ER-positive breast cancer. We conducted in vitro gain-of-function of NR2F1-AS1 variant1 and variant 4 in breast cancer BT474 cell line and applied microarray-based analysis.
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| Contributor(s) |
Calle AS, Kawamura Y, Mitsuhashi-Hironaka A, Ono M, Takeshita F, Ochiya T, Yamamoto Y |
| Citation(s) |
32392629 |
| Submission date |
Mar 20, 2019 |
| Last update date |
Jun 21, 2020 |
| Contact name |
Yusuke Yamamoto |
| E-mail(s) |
yuyamamo@ncc.go.jp
|
| Phone |
+81-335422511
|
| Organization name |
National cancer center research institute
|
| Lab |
Cellular signaling
|
| Street address |
5-1-1, Tsukiji, Chuo-ku
|
| City |
Chuo-ku |
| State/province |
Tokyo |
| ZIP/Postal code |
104-0045 |
| Country |
Japan |
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| Platforms (1) |
| GPL21185 |
Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Probe Name Version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA528288 |
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