Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing
Summary
Systematic comparison of multiple models of diabetes / insulin resistance reveals miR-29 as a commonality among them, and further analysis reveals it as a key therapeutic target for insulin resistance.
Overall design
Comparison of multiple models of diabetes at the small RNA-seq and RNA-seq level. Further sequencing analysis of miR-29 following perturbation using locked nucleic acids.
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