 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Sep 05, 2019 |
| Title |
Perturbation of the metabolic phenotypes of vaccination by the gut microbiome in humans [phase II] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We performed an experiment in humans, in which broad spectrum antibiotics were administered to healthy young adults, prior and subsequent to vaccination with the seasonal influenza vaccine. Transcriptional profiling of peripheral blood mononuclear cells was performed prior to the vaccination and as a time course following the vaccine administration.
|
| |
|
| Overall design |
In a follow up to the previous study, a total of 11 study participants aged 18-45 received a trivalent influenza vaccine (TIV) on day 0. XXXXXXX subjects were randomized to a five-day oral broad-spectrum antibiotic regimen consisting of neomycin, vancomycin, and metronidazole between day -3 and day 1. Vaccine was administered at Day 0. Biologic samples were collected and analyses performed at regular intervals.
|
| |
|
| Contributor(s) |
Hagan T, Cortese M, Kazmin D, Pulendran B |
| Citation(s) |
31491384 |
| Submission date |
Oct 01, 2018 |
| Last update date |
Feb 25, 2021 |
| Contact name |
Dmitri A Kazmin |
| E-mail(s) |
dkazmin@stanford.edu
|
| Organization name |
Stanford University
|
| Department |
Institute for Immunity, Transplantation and Infection
|
| Lab |
Bali Pulendran
|
| Street address |
240 Pasteur Dr
|
| City |
Palo Alto |
| State/province |
CA |
| ZIP/Postal code |
94304 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13158 |
[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate |
|
| Samples (54)
|
| GSM3409113 |
Subject # 34, day 0 |
| GSM3409114 |
Subject # 34, day 1 |
| GSM3409115 |
Subject # 34, day 3 |
| GSM3409116 |
Subject # 34, day 7 |
| GSM3409117 |
Subject # 35, day -3 (Screening) |
| GSM3409118 |
Subject # 35, day 0 |
| GSM3409119 |
Subject # 35, day 1 |
| GSM3409120 |
Subject # 35, day 3 |
| GSM3409121 |
Subject # 31, day 0 |
| GSM3409122 |
Subject # 35, day 7 |
| GSM3409123 |
Subject # 36, day -21 (Screening) |
| GSM3409124 |
Subject # 36, day 0 |
| GSM3409125 |
Subject # 36, day 1 |
| GSM3409126 |
Subject # 36, day 3 |
| GSM3409127 |
Subject # 36, day 7 |
| GSM3409128 |
Subject # 37, day -3 (Screening) |
| GSM3409129 |
Subject # 37, day 0 |
| GSM3409130 |
Subject # 37, day 1 |
| GSM3409131 |
Subject # 37, day 3 |
| GSM3409132 |
Subject # 31, day 1 |
| GSM3409133 |
Subject # 37, day 7 |
| GSM3409134 |
Subject # 38, day -21 (Screening) |
| GSM3409135 |
Subject # 38, day 0 |
| GSM3409136 |
Subject # 38, day 1 |
| GSM3409137 |
Subject # 38, day 3 |
| GSM3409138 |
Subject # 38, day 7 |
| GSM3409139 |
Subject # 43, day -21 (Screening) |
| GSM3409140 |
Subject # 43, day 0 |
| GSM3409141 |
Subject # 43, day 1 |
| GSM3409142 |
Subject # 43, day 3 |
| GSM3409143 |
Subject # 31, day 3 |
| GSM3409144 |
Subject # 43, day 7 |
| GSM3409145 |
Subject # 44, day -21 (Screening) |
| GSM3409146 |
Subject # 44, day 0 |
| GSM3409147 |
Subject # 44, day 1 |
| GSM3409148 |
Subject # 44, day 3 |
| GSM3409149 |
Subject # 44, day 7 |
| GSM3409150 |
Subject # 46, day -21 (Screening) |
| GSM3409151 |
Subject # 46, day 0 |
| GSM3409152 |
Subject # 46, day 1 |
| GSM3409153 |
Subject # 46, day 7 |
| GSM3409154 |
Subject # 31, day 7 |
| GSM3409155 |
Subject # 47, day -3 (Screening) |
| GSM3409156 |
Subject # 47, day 0 |
| GSM3409157 |
Subject # 47, day 1 |
| GSM3409158 |
Subject # 47, day 3 |
| GSM3409159 |
Subject # 47, day 7 |
| GSM3409160 |
Subject # 33, day -21 (Screening) |
| GSM3409161 |
Subject # 33, day 0 |
| GSM3409162 |
Subject # 33, day 1 |
| GSM3409163 |
Subject # 33, day 3 |
|
| This SubSeries is part of SuperSeries: |
| GSE120719 |
Perturbation of the metabolic phenotypes of vaccination by the gut microbiome in humans |
|
| Relations |
| BioProject |
PRJNA494241 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE120718_RAW.tar |
106.4 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...