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| Status |
Public on Jul 25, 2019 |
| Title |
In the Setting of Beta Cell Stress, the Pancreatic Duct Gland Transcriptome shows Characteristics of an Activated Regenerative Response |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The pancreatic duct gland (PDG) compartment has been proposed as a potential stem cell niche. Little is known of the molecular signature of the PDG compartment in either a quiescent state or the potentially activated state during beta cell stress characteristic of diabetes.
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| Overall design |
We performed RNA sequencing on RNA obtained from PDGs of wild type versus pre-diabetic HIP rats, a model of type 2 diabetes.
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| Contributor(s) |
Butler AE, Kirakossian D, Gurlo T, Gao F, Coppola G, Butler PC |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 25, 2018 |
| Last update date |
Jul 27, 2019 |
| Contact name |
Giovanni Coppola |
| E-mail(s) |
gcoppola@ucla.edu
|
| Phone |
310-794-4172
|
| Organization name |
UCLA
|
| Department |
Psychiatry and Neurology
|
| Lab |
Neurogenetics
|
| Street address |
1524 Gonda, 695 Charles Young Drive South
|
| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90095 |
| Country |
USA |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA482876 |
| SRA |
SRP155283 |
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