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| Status |
Public on Nov 20, 2018 |
| Title |
OnPLS-based multi-block data integration: a multivariate approach to interrogating biological interactions in asthma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Integration of multi-omics data remains a key challenge in fulfilling the potential of comprehensive systems biology.
This study aimed to explore the potential for the multi-block projection method (OnPLS) and multi-block variable influence on the projection (MB-VIOP) to interrogate an example systems medicine study, using a subset of 22 individuals from an asthma cohort.
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| Overall design |
Joint data structure in six data blocks was assessed: transcriptomics; metabolomics; targeted assays for sphingolipids, oxylipins, and fatty acids; and a clinical block including lung function, immune cell differentials, and cytokines.
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| Contributor(s) |
Singhania A, Reinke SN, Wheelock CE, Hinks TS |
| Citation(s) |
30335973 |
| Submission date |
May 18, 2018 |
| Last update date |
Nov 23, 2018 |
| Contact name |
Akul Singhania |
| E-mail(s) |
akul.singhania@crick.ac.uk
|
| Phone |
+442037963319
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| Organization name |
The Francis Crick Institute
|
| Street address |
1 Midland Road
|
| City |
London |
| ZIP/Postal code |
NW1 1AT |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL13158 |
[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate |
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| Samples (22)
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| Relations |
| BioProject |
PRJNA472083 |
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