|
| Status |
Public on Sep 30, 2020 |
| Title |
Gene Expression of Bone Marrow Endothelial Cells under Radiated and Radioprotective Conditions |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Bone Marrow Transplantation (BMT) depends greatly on transendothelial migration of stem cells from bloodstream to bone marrow. Therefore Bone Marrow Endothelial Cells (BMECs) becomes an essential component for successful BMT. Since BMT requires prior radiation therapy therefore it is necessary to study the behaviour of BMEC in irradiated and radiprotective conditions. We have conducted transcriptome profiling of Bone Marrow Endothelial Cells (BMECs) to identify the signalling mechanisms required for transendothelial migration to bone marrow under irradiated and radioprotected conditions.
|
| |
|
| Overall design |
Gene Expression of Bone Marrow Endothelial Cells 24hrs after treatment of cells either with amifostine or 6Gy radiation or both amifostine and radiation.
|
| |
|
| Contributor(s) |
Gangenahalli G, Gupta S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 03, 2018 |
| Last update date |
Oct 02, 2020 |
| Contact name |
Gurudutta U Gangenahalli |
| E-mail(s) |
gugdutta@rediffmail.com
|
| Phone |
9101123905144
|
| Organization name |
Institute of Nuclear Medicine & Allied Sciences
|
| Department |
Stem Cell Research Division
|
| Lab |
Stem Cell & Gene Therapy Research Group
|
| Street address |
Brig. S. K. Mazumdar Marg, Timarpur
|
| City |
Delhi |
| State/province |
Delhi |
| ZIP/Postal code |
110054 |
| Country |
India |
| |
|
| Platforms (1) |
| GPL21185 |
Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Probe Name Version] |
|
| Samples (12)
|
| GSM2912536 |
Endothelial Cells_ No radiation_AMF treated_rep1 |
| GSM2912537 |
Endothelial Cells_ No radiation_AMF treated_rep2 |
| GSM2912538 |
Endothelial Cells_ No radiation_AMF treated_rep3 |
| GSM2912539 |
Endothelial Cells_ 6Gy radiation_rep1 |
| GSM2912540 |
Endothelial Cells_ 6Gy radiation_rep2 |
| GSM2912541 |
Endothelial Cells_ 6Gy radiation_rep3 |
| GSM2912542 |
Endothelial Cells_ 6Gy radiation_AMF treated_rep1 |
| GSM2912543 |
Endothelial Cells_ 6Gy radiation_AMF treated_rep2 |
| GSM2912544 |
Endothelial Cells_ 6Gy radiation_AMF treated_rep3 |
|
| Relations |
| BioProject |
PRJNA428371 |
Less...
More...