NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE102536 Query DataSets for GSE102536
Status Public on Apr 18, 2018
Title Gene expression profiling after a chronic exposure to benzo[a]pyrene (B[a]P) and/or ethanol in steatotic or non-steatotic HepaRG cells.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The aim of this study was to determine in the human HepaRG cell line whether lipid overload (steatosis) could favor the cytotoxicity of benzo[a]pyrene (B[a]P) alone or in association with ethanol.
 
Overall design Differentiated HepaRG cells (Aninat et al., Drug Metab Dispos 2006) were treated during 16 days with or without a mixture of fatty acids (150 µM stearic acid and 150 µM oleic acid). After 2 days from the start of the experiments, steatotic and non-steatotic cells were also treated with 1 or 2.5 µM B[a]P, associated or not with 25 mM ethanol. Independent cultures were performed in triplicate. In total, 36 samples were analyzed in this study.
 
Contributor(s) Bucher S, Coulouarn C, Fromenty B
Citation(s) 29654281
Submission date Aug 11, 2017
Last update date Jul 25, 2021
Contact name Simon Bucher
E-mail(s) bucher.simon88@gmail.com
Phone 0677416760
Organization name INSERM U1241
Street address 2 Avenue du Pr. L. Bernard
City Rennes
ZIP/Postal code 35043
Country France
 
Platforms (1)
GPL21185 Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Probe Name Version]
Samples (36)
GSM2740230 HepaRG_ctrl_replicate1
GSM2740231 HepaRG_BAP_1µM_replicate1
GSM2740232 HepaRG_BAP_2.5µM_replicate1
Relations
BioProject PRJNA397977

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE102536_RAW.tar 111.6 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap