|
| Status |
Public on Jun 25, 2018 |
| Title |
Cerebellar gene expression in Δα6-Cre Crfr1 knock-out mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Corticotropin-releasing factor (CRF) and its type 1 receptor (CRFR1) play an important role in the behavioral and neuroendocrine responses to stressful challenges, facilitating or down-playing specific functions dependent on the region and goal involved. Despite the well-established expression CRFR1 in granular cells (GrCs), the role of this system in procedural motor performance and memory formation remains elusive. To investigate the role of CRFR1 expression in cerebellar GrCs, we conducted mRNA-Seq in a mouse model specifically depleted of CRFR1 in these cells (Δα6-Cre Crfr1).
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| |
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| Overall design |
mRNA-Seq of 6 wild-type (WT) and 6 conditional knock-out (cKO) mouse cerebella.
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| |
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| Contributor(s) |
Ezra-Nevo G, Engel M, Leshkowitz D, Deussing J, Chen A |
| Citation(s) |
29934353 |
| Submission date |
Jul 26, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Mareen Engel |
| E-mail(s) |
mareen_engel@psych.mpg.de
|
| Organization name |
Max-Planck-Institute of Psychiatry
|
| Department |
Stress Neurobiology and Neurogenetics
|
| Street address |
Kraepelinstr. 2-10
|
| City |
Munich |
| ZIP/Postal code |
80804 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (12)
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|
| Relations |
| BioProject |
PRJNA395846 |
| SRA |
SRP113587 |
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