NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE100093 Query DataSets for GSE100093
Status Public on Jun 23, 2017
Title Pharmacodynamics, Safety, and Clinical Efficacy of AMG 811, a Human Anti-Interferon-γ Antibody, in Patients With Discoid Lupus Erythematosus [skin]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary This is a phase I randomized, double-blind, placebo-controlled crossover study which sought to evaluate a single dose of AMG 811, an anti-IFNγ antibody, in patients with DLE.
The patients in sequence 1 received AMG 811 followed by placebo, while those in sequence 2 received placebo followed by AMG 811. Pharmacodynamic end points included global transcriptional analyses of lesional and nonlesional skin, IFNγ blockade signature (IGBS) transcriptional scores in the skin and blood, keratinocyte IFNγ RNA scores, and serum levels of CXCL10 protein
 
Overall design Sixteen patients with DLE were enrolled in the study (9 in sequence 1 and 7 in sequence 2). The patients in sequence 1 received AMG 811 (180mg) followed by placebo, while those in sequence 2 received placebo followed by AMG 811 (180 mg). Biopsy specimens of lesional and nonlesional skin were collected at baseline, and biopsy specimens of lesional skin were collected on days 15 and 57 postdosing.
 
Contributor(s) Werth VP, Fiorentino D, Sullivan BA, Boedigheimer MJ, Chiu K, Wang C, Arnold GE, Damore MA, Bigler J, Welcher AA, Russell CB, Martin DA, Chung JB
Citation(s) 28118537
Submission date Jun 15, 2017
Last update date Jul 25, 2021
Contact name Dan Baker
E-mail(s) bakerd@amgen.com
Phone 805-447-1000
Organization name Amgen Inc.
Department Molecular Sciences
Street address 1 Amgen Center Drive
City Thousand Oaks
State/province CA
ZIP/Postal code 91320
Country USA
 
Platforms (1)
GPL13158 [HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate
Samples (60)
GSM2671103 Lesional Skin Biopsy [45583000500_D-1]
GSM2671104 Non-lesional Skin Biopsy [45583000500_D-1]
GSM2671105 Lesional Skin Biopsy [45583000500_D15]
This SubSeries is part of SuperSeries:
GSE100431 Pharmacodynamics, Safety, and Clinical Efficacy of AMG 811, a Human Anti-Interferon-γ Antibody, in Patients With Discoid Lupus Erythematosus
Relations
BioProject PRJNA390658

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE100093_RAW.tar 131.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap