ZNF132 zinc finger protein 132 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF132provided by HGNC
Official Full Name: zinc finger protein 132provided by HGNC
Primary source: HGNC:HGNC:12916
See related: Ensembl:ENSG00000131849 MIM:604074; AllianceGenome:HGNC:12916
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: pHZ-12
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thyroid (RPKM 3.7), ovary (RPKM 2.5) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 19q13.43

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (58432814..58440153, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (61528799..61536138, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (58944181..58951520, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulated ZNF132 predicts unfavorable outcomes in breast Cancer via Hypermethylation modification.
Title: Downregulated ZNF132 predicts unfavorable outcomes in breast Cancer via Hypermethylation modification.
results suggest that ZNF132 plays an important role in the development of esophageal squamous cell carcinoma as a tumor suppressor gene and support the underlying mechanism caused by the DNA hypermethylation-mediated Sp1-binding decay and gene silencing.
Title: Epigenetic silencing of ZNF132 mediated by methylation-sensitive Sp1 binding promotes cancer progression in esophageal squamous cell carcinoma.
downregulation of ZNF132 is associated with aggressive prostate cancer.
Title: Downregulation of zinc finger protein 132 in prostate cancer is associated with aberrant promoter hypermethylation and poor prognosis.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene variants associated with ischemic stroke: the cardiovascular health study.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

RH98347 (e-PCR)
- UniSTS:86391

SHGC-153581 (e-PCR)
- UniSTS:177828

RH71196 (e-PCR)
- UniSTS:77264

ZNF132__4959 (e-PCR)
- UniSTS:464619

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 132

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003433.4 → NP_003424.3 zinc finger protein 132

See identical proteins and their annotated locations for NP_003424.3

Status: VALIDATED

Source sequence(s)

AK057460, BC109107, BQ774411, U09411

Consensus CDS

CCDS12980.1

UniProtKB/Swiss-Prot

P52740, Q32MI9

Related

ENSP00000254166.2, ENST00000254166.4

Conserved Domains (3) summary

COG5048
Location:105 → 528

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:433 → 453

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:37 → 78

KRAB; KRAB box