Conserved Protein Domain Family
KRAB
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pfam01352: KRAB (this model, PSSM-Id:307490 is obsolete and has been replaced by 460171)
KRAB box
The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.
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Statistics
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PSSM-Id: 307490
Aligned: 560 rows
Threshold Bit Score: 45.8021
Created: 14-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4V8E9        13 SVKFEDVSLTFTKEEWAQLDLQQKCLYREIMMENYNNMISVE 54   Norway rat
XP_007488698  14 LVTFVDVAVNLTQEEWHLLGPDQRSLYRDVMLENYGNIVSLG 55   gray short-tailed opossum
XP_014310714  13 LLTFEDVAVFFTQEEWDYLDPAQRSLYKDVMMENYGNLVSLD 54   little brown bat
XP_008055732  14 LVTFEDVAVYFIRKEWKRLEPAQRDLYRDVMLENYGNVFSLD 55   Philippine tarsier
XP_011833206  13 PVTFEDMAMYLTREEWRPLDPAQRDLYRDVMQENYGNVVSLD 54   drill
XP_014443939  76 FVTFEDVAVHLTREEWGCLDSVQRDLYREVMLENYGNVVSLG 117  Chinese tree shrew
XP_012397361 157 SLMFKDVAVYLTQEEWGCLGPAQRGLYRDVMLENYGNLVSLG 198  Tasmanian devil
XP_016287451 100 SMMFEDIAVYLTQEEWGLLEPAQRNLYRNVMMENYRNIVSLG 141  gray short-tailed opossum
XP_007498538  13 svMFEDMAMYLTPEEWGQADPTQRTLYRDMMLESYRNDISLD 54   gray short-tailed opossum
XP_007666651  14 PVTFEDVAVYLTREEWKLLGPSQRDLYRDTMLENYRHVVSLG 55   platypus
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