camk4 calcium/calmodulin-dependent protein kinase IV [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: camk4provided by ZNC
Official Full Name: calcium/calmodulin-dependent protein kinase IVprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-76
See related: Ensembl:ENSDARG00000005372 AllianceGenome:ZFIN:ZDB-GENE-050417-76
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fj42a03; zgc:110275
Summary: Enables protein kinase activity. Acts upstream of or within definitive hemopoiesis. Located in cytosol and nucleus. Is expressed in nervous system and pharyngeal arch. Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 5

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (55763276..55848359, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (55093059..55178142, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We identified the zebrafish homologue of CaMKIV (zCaMKIV) on the basis of biochemical characterization. zCaMKIV showed similar biochemical properties as well as tissue and subcellular distributions to rat CaMKIV (rCaMKIV)
Title: A minimum size homologue of Ca2+/calmodulin-dependent protein kinase IV naturally occurring in zebrafish.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fj47g07.y1 (e-PCR)
- UniSTS:199426

fj42a03.x1 (e-PCR)
- UniSTS:188533

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: calcium/calmodulin-dependent protein kinase type IV

Names: zCaMKIV

NP_001017607.1

EC 2.7.11.17

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017607.1 → NP_001017607.1 calcium/calmodulin-dependent protein kinase type IV

See identical proteins and their annotated locations for NP_001017607.1

Status: PROVISIONAL

Source sequence(s)

BC092841

UniProtKB/TrEMBL

B2GPN2, F6NSB3, Q568I9

Related

ENSDARP00000108452.2, ENSDART00000130891.3

Conserved Domains (2) summary

cd14085
Location:25 → 318

STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV

pfam00069
Location:29 → 283

Pkinase; Protein kinase domain