3UZT_A 191 FSVHRIIGRGGFGEVYGCRKaDTGKMYAMKCLDKKRIKMKQGe-----TLALNERIMLSLVStgdCPFIVCMSYAFHT-- 263 cattle 2IN6_A 11 FHELEKIGSGEFGSVFKCVKrLDGCIYAIKRSKKPLAGSVDE------QNALREVYAHAVLGq--HSHVVRYFSAWAE-- 80 human 3DTC_A 9 LTLEEIIGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQt----iENVRQEAKLFAMLK---HPNIIALRGVCLK-- 77 human P17801 534 RKFKVELGRGESGTVYKGVl-EDDRHVAVKKLENVRQGK---------EVFQAELSVIGRIN---HMNLVRIWGFCSE-- 598 Zea mays Q03497 620 YANLVKIGQGASGGVYTAYEiGTNVSVAIKQMNLEKQPKKEL--------IINEILVMKGSK---HPNIVNFIDSYVL-- 686 Saccharomyces cere... P27636 25 YHLKQVIGRGSYGVVYKAINkHTDQVVAIKEVVYENDEELND--------IMAEISLLKNLN---HNNIVKYHGFIRK-- 91 Saccharomyces cere... P28829 394 WIRGALIGSGSFGQVYLGMNaSSGELMAVKQVILDSVSESKDrhakllDALAGEIALLQELS---HEHIVQYLGSNLN-- 468 Schizosaccharomyce... P32490 221 IETLGILGEGAGGSVSKCKLkNGSKIFALKVINTLNTDPEYQ------KQIFRELQFNRSFQ---SEYIVRYYGMFTDd- 290 Saccharomyces cere... P06784 191 LVQLGKIGAGNSGTVVKALHvPDSKIVAKKTIPVEQNNSTII------NQLVRELSIVKNVKp--HENIITFYGAYYNqh 262 Saccharomyces cere... CAR64526 532 VMLSTRIGSGSFGTVYKGK---WHGDVAVKILKVVDPTPEQF------QAFRNEVAVLRKTR---HVNILLFMGYMT--- 596 human
3UZT_A 264 -PDKLSFILDLMNGGD----LHYHLSqh------gvFSEA-------DMR-FYAAEIILGLEHMH-NRF---VVYRDLKP 320 cattle 2IN6_A 81 -DDHMLIQNEYCNGGS----LADAISenyr--imsyFKEA-------ELK-DLLLQVGRGLRYIH-SMS---LVHMDIKP 141 human 3DTC_A 78 -EPNLCLVMEFARGGP----LNRVLSgk-------rIPPD-------ILV-NWAVQIARGMNYLH-DEAivpIIHRDLKS 136 human P17801 599 -GSHRLLVSEYVENGS----LANIL-----------FSEGgnilldwEGRfNIALGVAKGLAYLH-HEClewVIHCDVKP 661 Zea mays Q03497 687 -KGDLWVIMEYMEGGS----LTDVVth-------ciLTEG-------QIG-AVCRETLSGLEFLH-SKG---VLHRDIKS 742 Saccharomyces cere... P27636 92 -SYELYILLEYCANGS----LRRLISrss-----tgLSEN-------ESK-TYVTQTLLGLKYLH-GEG---VIHRDIKA 149 Saccharomyces cere... P28829 469 -SDHLNIFLEYVPGGS----VAGLLTmy------gsFEET-------LVK-NFIKQTLKGLEYLH-SRG---IVHRDIKG 525 Schizosaccharomyce... P32490 291 eNSSIYIAMEYMGGRSldaiYKNLLErg------grISEK-------VLG-KIAEAVLRGLSYLH-EKK---VIHRDIKP 352 Saccharomyces cere... P06784 263 iNNEIIILMEYSDCGS----LDKILSvykrfvqrgtVSSKktwfnelTIS-KIAYGVLNGLDHLYrQYK---IIHRDIKP 334 Saccharomyces cere... CAR64526 597 -KDNLAIVTQWCEGSS----LYKHLHvqe-----tkFQMF-------QLI-DIARQTAQGMDYLH-AKN---IIHRDMKS 654 human
3UZT_A 321 ANILLDe-----------HGH--------VRISDLGLACDFSKKK--------PHASVGTHGYMAPEVLqKG---VAY-D 369 cattle 2IN6_A 142 SNIFISrtsipnaaseegDEDdwasnkvmFKIGDLGHVTRISS----------PQVEEGDSRFLANEVL-QE---NYThL 207 human 3DTC_A 137 SNILILq-----------KVEngdlsnkiLKITDFGLAREWHRTT--------KMSAAGAYAWMAPEVI-RA---SMF-S 192 human P17801 662 ENILLD------------QAFe-------PKITDFGLVKLLNRGGst----qnVSHVRGTLGYIAPEWV-SS---LPI-T 713 Zea mays Q03497 743 DNILLSm-----------EGD--------IKLTDFGFCAQINELNl------kRTTMVGTPYWMAPEVV-SR---KEY-G 792 Saccharomyces cere... P27636 150 ANILLS------------ADNt-------VKLADFGVSTIVNSS---------ALTLAGTLNWMAPEIL-GN---RGA-S 196 Saccharomyces cere... P28829 526 ANILVDn-----------KGK--------IKISDFGISKKLELNStstktggaRPSFQGSSFWMAPEVV-KQ---TMH-T 581 Schizosaccharomyce... P32490 353 QNILLNe-----------NGQ--------VKLCDFGVSGEAVNSL--------ATTFTGTSFYMAPERI-QG---QPY-S 400 Saccharomyces cere... P06784 335 SNVLINs-----------KGQ--------IKLCDFGVSKKLINSI--------ADTFVGTSTYMSPERI-QG---NVY-S 382 Saccharomyces cere... CAR64526 655 NNIFLH------------EGLt-------VKIGDFGLATVKSRWSgs----qqVEQPTGSVLWMAPEVI-RMqdnNPF-S 709 human
3UZT_A 370 SSADWFSLGCMLFKLLRGHSPFRqhkTKDkheiDRMTl----------------------TMAVELPDSF----SPELRS 423 cattle 2IN6_A 208 PKADIFALALTVVCA-AGAEPLP---RNGdqwhEIRQgrlpr---------------------------ipqvlSQEFTE 256 human 3DTC_A 193 KGSDVWSYGVLLWELLTGEVPFRgidGLAvaygVAMN-----------------------KLALPIPSTC----PEPFAK 245 human P17801 714 AKVDVYSYGVVLLELLTGTRVSElvgGTDevhsMLRKlvrmlsaklegeeqswidgyldsKLNRPVNYVQ----ARTLIK 789 Zea mays Q03497 793 PKVDIWSLGIMIIEMIEGEPPYL------------NEtplraly----------liatngTPKLKEPENL----SSSLKK 846 Saccharomyces cere... P27636 197 TLSDIWSLGATVVEMLTKNPPYHnltDANiyyaVEND-------------------------TYYPPSSF----SEPLKD 247 Saccharomyces cere... P28829 582 EKTDIWSLGCLVIEMLTSKHPYP----------NCDQmqaif--------------rigeNILPEFPSNI----SSSAID 633 Schizosaccharomyce... P32490 401 VTSDVWSLGLTILEVANGKFPCS----SEkmaaNIAPfellmw-----------iltftpELKDEPESNIi--wSPSFKS 463 Saccharomyces cere... P06784 383 IKGDVWSLGLMIIELVTGEFPLGghnDTPdgilDLLQri--------------------vNEPSPRLPKDri-ySKEMTD 441 Saccharomyces cere... CAR64526 710 FQSDVYSYGIVLYELMTGELPYShinNRDqiifMVGR-----------------------GYASPDLSKLykncPKAMKR 766 human
3UZT_A 424 LLEGLLQRDVNRRLGclgrgAQEVKESPFF 453 cattle 2IN6_A 257 LLKVMIHPDPERRPS-----AMALVKHSVL 281 human 3DTC_A 246 LMEDCWNPDPHSRPS-----FTNILDQ--L 268 human P17801 790 LAVSCLEEDRSKRPT-----MEHAVQtlls 814 Zea mays Q03497 847 FLDWCLCVEPEDRAS-----ATELLHDEYI 871 Saccharomyces cerevisiae S288c P27636 248 FLSKCFVKNMYKRPT-----ADQLLKHVWI 272 Saccharomyces cerevisiae S288c P28829 634 FLEKTFAIDCNLRPT-----ASELLSHPFV 658 Schizosaccharomyces pombe 972h- P32490 464 FIDYCLKKDSRERPS-----PRQMINHPWI 488 Saccharomyces cerevisiae S288c P06784 442 FVNRCCIKNERERSS-----IHELLHHDLI 466 Saccharomyces cerevisiae S288c CAR64526 767 LVADCVKKVKEERPL-----FPQILSSIEL 791 human
Jiyao W et al.(2023). "The conserved domain database in 2023.",