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    KDR kinase insert domain receptor [ Ovis aries (sheep) ]

    Gene ID: 443087, updated on 5-Mar-2024

    Summary

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    Gene symbol
    KDR
    Gene description
    kinase insert domain receptor
    See related
    EnsemblRapid:ENSOARG00020015634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Also known as
    flk-1; VEGFR-2
    Orthologs
    human mouse all
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    Genomic context

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    See KDR in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 6 NC_056059.1 (71265734..71315329, complement)

    Chromosome 6 - NC_056059.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL22-like Neighboring gene mitochondrial-processing peptidase subunit beta-like Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC114115412 Neighboring gene steroid 5 alpha-reductase 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056059.1 Chromosome 6 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. VEGF increases the permeability of sheep pleura ex vivo through VEGFR2 stimulation. Peppa VI, et al. Cytokine, 2014 Oct. PMID 24986423
    2. VEGF receptors mediate hypoxic remodeling of adult ovine carotid arteries. Adeoye OO, et al. J Appl Physiol (1985), 2014 Oct 1. PMID 25038104, Free PMC Article
    3. Placental expression of VEGF, PlGF and their receptors in a model of placental insufficiency-intrauterine growth restriction (PI-IUGR). Regnault TR, et al. Placenta, 2002 Feb-Mar. PMID 11945079
    4. Vascular endothelial growth factor acts through novel, pregnancy-enhanced receptor signalling pathways to stimulate endothelial nitric oxide synthase activity in uterine artery endothelial cells. Grummer MA, et al. Biochem J, 2009 Jan 15. PMID 18816248, Free PMC Article
    5. Pattern of expression of vascular endothelial growth factor and its receptors in the ovine choroid plexus during long and short photoperiods. Szczepkowska A, et al. Cell Tissue Res, 2012 Oct. PMID 22622803, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VEGF has a direct effect on the pleural mesothelium rendering it more permeable and this effect is mediated through the stimulation of VEGF receptor 2.
      Title: VEGF increases the permeability of sheep pleura ex vivo through VEGFR2 stimulation.
    2. VEGF receptor levels were significantly increased by 107% (VEGF-R1) and 156% (VEGF-R2) in hypoxic compared with normoxic arteries.
      Title: VEGF receptors mediate hypoxic remodeling of adult ovine carotid arteries.
    3. VEGF(165) activation of eNOS is completely inhibited by wortmannin
      Title: Vascular endothelial growth factor acts through novel, pregnancy-enhanced receptor signalling pathways to stimulate endothelial nitric oxide synthase activity in uterine artery endothelial cells.
    4. The objective of the study was to determine the expression of vascular endothelial growth factor (VEGF-A), tyrosine kinase receptors Flt-1 and KDR and KDR co-receptor neuropilin 1 (NRP-1) in ovine choroid plexus during different photoperiods.
      Title: Pattern of expression of vascular endothelial growth factor and its receptors in the ovine choroid plexus during long and short photoperiods.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables vascular endothelial growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in endothelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vascular endothelial growth factor receptor 2
    Names
    vascular endothelial growth factor receptor-2
    NP_001265494.1
    XP_012034745.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278565.2 → NP_001265494.1  vascular endothelial growth factor receptor 2 precursor

      Status: VALIDATED

      Source sequence(s)
      PEKD01002054
      UniProtKB/TrEMBL
      A0A6P3CXG7, A0A836A6Z9, W5NSG6
      Related
      ENSOARP00020019891.1, ENSOART00020023995.2
      Conserved Domains (9) summary
      cd05862
      Location:239 → 326
      Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
      cd05864
      Location:348 → 417
      Ig2_VEGFR-2; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 2 (VEGFR-2)
      smart00408
      Location:680 → 744
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:340 → 417
      IG_like; Immunoglobulin like
      pfam07679
      Location:667 → 754
      I-set; Immunoglobulin I-set domain
      cd05103
      Location:826 → 1167
      PTKc_VEGFR2; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2
      pfam07714
      Location:834 → 1160
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13895
      Location:551 → 652
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:427 → 482
      Ig_3; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056059.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      71265734..71315329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012179355.5 → XP_012034745.1  vascular endothelial growth factor receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A836A6Z9
      Related
      ENSOARP00020020724.1, ENSOART00020024964.2
      Conserved Domains (9) summary
      cd05862
      Location:239 → 326
      Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
      cd05864
      Location:348 → 417
      Ig2_VEGFR-2; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 2 (VEGFR-2)
      smart00408
      Location:680 → 744
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:340 → 417
      IG_like; Immunoglobulin like
      pfam07679
      Location:667 → 754
      I-set; Immunoglobulin I-set domain
      cd05103
      Location:826 → 1167
      PTKc_VEGFR2; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2
      pfam07714
      Location:834 → 1160
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13895
      Location:551 → 652
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:427 → 482
      Ig_3; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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