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    HIP-R Hsc/Hsp70-interacting protein related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31335, updated on 5-May-2024

    Summary

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    Official Symbol
    HIP-Rprovided by FlyBase
    Official Full Name
    Hsc/Hsp70-interacting protein relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029676
    Locus tag
    Dmel_CG2947
    See related
    AllianceGenome:FB:FBgn0029676
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe1A9; CG2947; Dmel\CG2947; Hip
    Summary
    Predicted to enable Hsp70 protein binding activity and chaperone binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding and protein-containing complex assembly. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Is expressed in adult head and organism. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See HIP-R in Genome Data Viewer
    Location:
    3F1-3F1; 1-5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3789969..3792477)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3684002..3686510)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ras-like protein A Neighboring gene Tousled-like kinase Neighboring gene mir-4962 stem loop Neighboring gene long non-coding RNA:CR44117 Neighboring gene pseudo Neighboring gene Circadianly Regulated Gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Wang AM, et al. Nat Chem Biol, 2013 Feb. PMID 23222885, Free PMC Article
    2. Duplicate gene evolution toward multiple fates at the Drosophila melanogaster HIP/HIP-Replacement locus. Hogan CC, et al. J Mol Evol, 2009 Apr. PMID 19333534
    3. FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Demontis F, et al. Cell, 2010 Nov 24. PMID 21111239, Free PMC Article
    4. Drosophila models of Alzheimer's disease: advances, limits, and perspectives. Bouleau S, et al. J Alzheimers Dis, 2015. PMID 25697708
    5. Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1. Lou WP, et al. Front Mol Neurosci, 2017. PMID 29379413, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp70 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables heat shock protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone cofactor-dependent protein refolding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein-containing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Hsc/Hsp70-interacting protein related
    Names
    CG2947-PA
    CG2947-PB
    CG2947-PD
    HIP-R-PA
    HIP-R-PB
    HIP-R-PD
    anon-fast-evolving-1A9

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      3789969..3792477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166988.4 → NP_726885.1  Hsc/Hsp70-interacting protein related, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726885.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0L9I4, C0L9I8, C4NYP8, C9QP24, Q86DR2, Q86DR3, Q86DR4, Q86DR5, Q86DR6, Q86DR7, Q86DR8, Q86DR9, Q86DS0, Q86DS1, Q86DS2, Q86DS3, Q8IRT4
      UniProtKB/TrEMBL
      E2QD63
      Related
      FBpp0070573
      Conserved Domains (4) summary
      smart00727
      Location:299 → 336
      STI1; Heat shock chaperonin-binding motif
      PLN03088
      Location:126 → 235
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      cd14438
      Location:10 → 47
      Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
      sd00006
      Location:126 → 154
      TPR; TPR repeat [structural motif]

    2. NM_166989.5 → NP_726886.1  Hsc/Hsp70-interacting protein related, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726886.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0L9I4, C0L9I8, C4NYP8, C9QP24, Q86DR2, Q86DR3, Q86DR4, Q86DR5, Q86DR6, Q86DR7, Q86DR8, Q86DR9, Q86DS0, Q86DS1, Q86DS2, Q86DS3, Q8IRT4
      UniProtKB/TrEMBL
      E2QD63
      Related
      FBpp0070572
      Conserved Domains (4) summary
      smart00727
      Location:299 → 336
      STI1; Heat shock chaperonin-binding motif
      PLN03088
      Location:126 → 235
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      cd14438
      Location:10 → 47
      Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
      sd00006
      Location:126 → 154
      TPR; TPR repeat [structural motif]

    3. NM_001014719.2 → NP_001014719.2  Hsc/Hsp70-interacting protein related, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014719.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0L9I4, C0L9I8, C4NYP8, C9QP24, Q86DR2, Q86DR3, Q86DR4, Q86DR5, Q86DR6, Q86DR7, Q86DR8, Q86DR9, Q86DS0, Q86DS1, Q86DS2, Q86DS3, Q8IRT4
      UniProtKB/TrEMBL
      E2QD63
      Conserved Domains (4) summary
      smart00727
      Location:299 → 336
      STI1; Heat shock chaperonin-binding motif
      PLN03088
      Location:126 → 235
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      cd14438
      Location:10 → 47
      Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
      sd00006
      Location:126 → 154
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C4NYP8.2
    E2QD63 E2QD63
    Q86DS1.2 Q86DS1

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