AICDA activation induced cytidine deaminase [Gallus gallus (chicken)] - Gene

Summary

Symbol: AICDAprovided by CGNC
Full Name: activation induced cytidine deaminaseprovided by CGNC
Primary source: CGNC:10639
See related: Ensembl:ENSGALG00010022690
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: AID
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (75917278..75922983, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (76128456..76134151, complement)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results, therefore, identify residues in AID involved in its in vivo targeting and suggest they might act through interaction with CTNNBL1, giving possible insight into the linkage between AID recruitment and target-gene transcription.
Title: Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1.
Cis-acting DNA boundary elements restrict AID activity to the IgL locus and guard the genome in the vicinity of the IgL gene from deleterious mutations.
Title: AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene.
findings demonstrate that Bach2 promotes immunoglobulin gene conversion (GCV by increasing the expression of activation-induced cytidine deaminase (AID); regulation of AID is independent of Blimp-1 and BACH2-deficient cells have altered expression of several genes regulating AID expression, stability and function
Title: Bach2 regulates AID-mediated immunoglobulin gene conversion and somatic hypermutation in DT40 B cells.
These results suggest that SRSF1-3 (a splicing isoform of SRSF1)promotes nuclear localization of AID probably by forming a nuclear protein complex, which might stabilize nuclear AID and induce immunoglobulin variable region diversification in an AID C-terminus-dependent manner.
Title: SRSF1-3 contributes to diversification of the immunoglobulin variable region gene by promoting accumulation of AID in the nucleus.
Studies indicate that gene conversion mediated by activation-induced cytidine deaminase (AID) has been found to contribute to generation of the primary antibody repertoire.
Title: Diversification of the Primary Antibody Repertoire by AID-Mediated Gene Conversion.
Concerted action of activation-induced cytidine deaminase and uracil-DNA glycosylase reduces covalently closed circular DNA of duck hepatitis B virus.
Title: Concerted action of activation-induced cytidine deaminase and uracil-DNA glycosylase reduces covalently closed circular DNA of duck hepatitis B virus.
RNA polymerase II pausing during polyA site recognition may facilitate persistence of negative supercoils, exposing the coding single strand and allowing the nascent RNA intermittent reannealing with the template strand, for prolonged access of AICDA.
Title: Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID.
results suggest that eEF1A is a cytosolic retention factor for AID and extend on the multiple moonlighting functions of eEF1A
Title: Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A).
Activation-induced cytidine deaminase targets all genes expressed in mutating B cells that are associated with CAGGTG motifs in the appropriate context.
Title: Attracting AID to targets of somatic hypermutation.
Data show that the regulatory element plays a role in recruiting AID (AICDA) to the Ig lambda locus.
Title: The recruitment of activation induced cytidine deaminase to the immunoglobulin locus by a regulatory element.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cytidine deaminase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA cytosine deamination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in DNA demethylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cytidine to uridine editing	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: single-stranded DNA cytosine deaminase

NP_001230151.1

EC 3.5.4.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001243222.2 → NP_001230151.1 single-stranded DNA cytosine deaminase

See identical proteins and their annotated locations for NP_001230151.1

Status: VALIDATED

Source sequence(s)

JAENSK010000015

UniProtKB/TrEMBL

E1BVI0

Related

ENSGALP00010033386.1, ENSGALT00010055184.1

Conserved Domains (1) summary

pfam18778
Location:5 → 180

NAD1; Novel AID APOBEC clade 1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

75917278..75922983 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

76128456..76134151 complement

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GenBank, FASTA, Sequence Viewer (Graphics)