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    KDM4C lysine demethylase 4C [ Homo sapiens (human) ]

    Gene ID: 23081, updated on 3-Apr-2024

    Summary

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    Official Symbol
    KDM4Cprovided by HGNC
    Official Full Name
    lysine demethylase 4Cprovided by HGNC
    Primary source
    HGNC:HGNC:17071
    See related
    Ensembl:ENSG00000107077 Ensembl:ENSG00000293552 MIM:605469; AllianceGenome:HGNC:17071
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GASC1; JHDM3C; JMJD2C; TDRD14C
    Summary
    This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
    Expression
    Ubiquitous expression in lymph node (RPKM 3.4), bone marrow (RPKM 3.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    9p24.1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (6720863..7175648)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (6715554..7172114)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (6720863..7175648)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28200 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:6707295-6707509 Neighboring gene uncharacterized LOC124902117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28203 Neighboring gene long intergenic non-protein coding RNA 2851 Neighboring gene PRELI domain containing 3B pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28205 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:6756064-6756775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:6761325-6762007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:6766791-6767436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:6767437-6768080 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:6771154-6772127 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:6775214-6775806 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:6776399-6776990 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:6776991-6777582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:6789083-6789798 Neighboring gene SNRPE pseudogene 2 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:6808287-6808846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:6834601-6835322 Neighboring gene actin gamma 1 pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19772 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:6940065-6940565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:7147699-7148200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:7148201-7148700 Neighboring gene NANOG hESC enhancer GRCh37_chr9:7185598-7186113 Neighboring gene uncharacterized LOC105375969 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:7240589-7241138 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:7284400-7285015 Neighboring gene uncharacterized LOC105375970 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:7319761-7320960 Neighboring gene uncharacterized LOC102723994

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas. Lopez C, et al. Haematologica, 2023 Feb 1. PMID 35522148, Free PMC Article
    2. KDM4C in germinal center lymphoma: a new piece of the epigenetic puzzle. Close K, et al. Haematologica, 2023 Feb 1. PMID 35484653, Free PMC Article
    3. Histone Demethylase GASC1 Inhibitor Targeted GASC1 Gene to Inhibit the Malignant Transformation of Esophageal Cancer through the NOTCH-MAPK Signaling Pathway. Li Q, et al. Ann Clin Lab Sci, 2022 Mar. PMID 35414503
    4. JMJD2C-mediated long non-coding RNA MALAT1/microRNA-503-5p/SEPT2 axis worsens non-small cell lung cancer. Zhang J, et al. Cell Death Dis, 2022 Jan 19. PMID 35046387, Free PMC Article
    5. Novel germline variant in the histone demethylase and transcription regulator KDM4C induces a multi-cancer phenotype. Katainen R, et al. J Med Genet, 2022 Jul. PMID 34281993, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis.
      Title: The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis.
    2. KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations.
      Title: KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations.
    3. The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2[V617F] mutated cells.
      Title: The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2(V617F) mutated cells.
    4. Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.
      Title: Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.
    5. KDM4C in germinal center lymphoma: a new piece of the epigenetic puzzle.
      Title: KDM4C in germinal center lymphoma: a new piece of the epigenetic puzzle.
    6. Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury.
      Title: Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury.
    7. Novel germline variant in the histone demethylase and transcription regulator KDM4C induces a multi-cancer phenotype.
      Title: Novel germline variant in the histone demethylase and transcription regulator KDM4C induces a multi-cancer phenotype.
    8. Histone Demethylase GASC1 Inhibitor Targeted GASC1 Gene to Inhibit the Malignant Transformation of Esophageal Cancer through the NOTCH-MAPK Signaling Pathway.
      Title: Histone Demethylase GASC1 Inhibitor Targeted GASC1 Gene to Inhibit the Malignant Transformation of Esophageal Cancer through the NOTCH-MAPK Signaling Pathway.
    9. JMJD2C-mediated long non-coding RNA MALAT1/microRNA-503-5p/SEPT2 axis worsens non-small cell lung cancer.
      Title: JMJD2C-mediated long non-coding RNA MALAT1/microRNA-503-5p/SEPT2 axis worsens non-small cell lung cancer.
    10. Inhibition of KDM4C/c-Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism.
      Title: Inhibition of KDM4C/c-Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism.
    Submit: New GeneRIF Correction See all GeneRIFs (50)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog
    Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.
    EBI GWAS Catalog
    Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25668, FLJ25949, KIAA0780

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables H3K9me3 modified histone binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone H3K36 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K36 demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K9 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K9 demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K9 demethylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H3K9me2/H3K9me3 demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone H3K9me2/H3K9me3 demethylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone demethylase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables histone demethylase activity TAS
    Traceable Author Statement
    more info
    		  
    enables nuclear androgen receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in blastocyst formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of androgen receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pericentric heterochromatin IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysine-specific demethylase 4C
    Names
    JmjC domain-containing histone demethylation protein 3C
    [histone H3]-trimethyl-L-lysine(9) demethylase 4C
    gene amplified in squamous cell carcinoma 1 protein
    jumonji domain-containing protein 2C
    lysine (K)-specific demethylase 4C
    tudor domain containing 14C
    NP_001140167.1
    NP_001140168.1
    NP_001291268.1
    NP_001291269.1
    NP_001291270.1
    NP_001340926.1
    NP_001340927.1
    NP_001340928.1
    NP_001340929.1
    NP_001340930.1
    NP_055876.2
    XP_016869987.1
    XP_047278982.1
    XP_047278983.1
    XP_047278984.1
    XP_047278985.1
    XP_047278986.1
    XP_054218414.1
    XP_054218415.1
    XP_054218416.1
    XP_054218417.1
    XP_054218418.1
    XP_054218419.1
    XP_054218420.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146695.4 → NP_001140167.1  lysine-specific demethylase 4C isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL137020, AL354707, AL445592, AL513412
      Consensus CDS
      CCDS55286.1
      UniProtKB/Swiss-Prot
      Q9H3R0
      Related
      ENSP00000445427.1, ENST00000543771.5
      Conserved Domains (4) summary
      cd15577
      Location:644 → 746
      PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
      pfam02373
      Location:177 → 293
      JmjC; JmjC domain, hydroxylase
      cl15840
      Location:16 → 57
      JmjN; jmjN domain
      cl22851
      Location:755 → 808
      PHD_SF; PHD finger superfamily

    2. NM_001146696.2 → NP_001140168.1  lysine-specific demethylase 4C isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL137020, AL354707, AL445592, AL513412
      Consensus CDS
      CCDS55285.1
      UniProtKB/Swiss-Prot
      Q9H3R0
      Related
      ENSP00000440656.3, ENST00000536108.6
      Conserved Domains (4) summary
      cd15577
      Location:666 → 768
      PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
      pfam02373
      Location:199 → 315
      JmjC; JmjC domain, hydroxylase
      cl15840
      Location:38 → 79
      JmjN; jmjN domain
      cl22851
      Location:777 → 830
      PHD_SF; PHD finger superfamily

    3. NM_001304339.4 → NP_001291268.1  lysine-specific demethylase 4C isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL137020, AL161443, AL354707, AL445592, AL513412
      Related
      ENSP00000370707.3, ENST00000381306.7
      Conserved Domains (6) summary
      cd15577
      Location:644 → 746
      PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
      cd15715
      Location:755 → 864
      ePHD_JMJD2C; Extended PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
      pfam02373
      Location:177 → 293
      JmjC; JmjC domain, hydroxylase
      cd20465
      Location:879 → 932
      Tudor_JMJD2C_rpt1; first Tudor domain found in Jumonji domain-containing protein 2C (JMJD2C) and similar proteins
      cd20468
      Location:936 → 995
      Tudor_JMJD2C_rpt2; second Tudor domain found in Jumonji domain-containing protein 2C (JMJD2C) and similar proteins
      cl15840
      Location:16 → 57
      JmjN; jmjN domain

    4. NM_001304340.4 → NP_001291269.1  lysine-specific demethylase 4C isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL137020, AL161443, AL354707, AL445592, AL513412
      UniProtKB/TrEMBL
      B4E239
      Conserved Domains (5) summary
      cd15577
      Location:389 → 491
      PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
      pfam02373
      Location:1 → 112
      JmjC; JmjC domain, hydroxylase
      cd20465
      Location:624 → 677
      Tudor_JMJD2C_rpt1; first Tudor domain found in Jumonji domain-containing protein 2C (JMJD2C) and similar proteins
      cd20468
      Location:681 → 740
      Tudor_JMJD2C_rpt2; second Tudor domain found in Jumonji domain-containing protein 2C (JMJD2C) and similar proteins
      cl22851
      Location:500 → 609
      PHD_SF; PHD finger superfamily

    5. NM_001304341.4 → NP_001291270.1  lysine-specific demethylase 4C isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL354707
      Consensus CDS
      CCDS78379.1
      UniProtKB/TrEMBL
      B0QZ60
      Related
      ENSP00000383990.3, ENST00000401787.7
      Conserved Domains (1) summary
      cl15840
      Location:16 → 57
      JmjN; jmjN domain

    6. NM_001353997.3 → NP_001340926.1  lysine-specific demethylase 4C isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL137020, AL161443, AL354707, AL445592, AL513412
      Conserved Domains (5) summary
      smart00333
      Location:912 → 966
      TUDOR; Tudor domain
      pfam02373
      Location:177 → 293
      JmjC; JmjC domain, hydroxylase
      cd15577
      Location:644 → 746
      PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
      cd15715
      Location:755 → 864
      ePHD_JMJD2C; Extended PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
      cl15840
      Location:16 → 57
      JmjN; jmjN domain

    7. NM_001353998.3 → NP_001340927.1  lysine-specific demethylase 4C isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL137020, AL354707, AL445592, AL513412
      Conserved Domains (4) summary
      pfam02373
      Location:177 → 293
      JmjC; JmjC domain, hydroxylase
      cd15577
      Location:644 → 746
      PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
      cl15840
      Location:16 → 57
      JmjN; jmjN domain
      cl22851
      Location:755 → 772
      PHD_SF; PHD finger superfamily

    8. NM_001353999.3 → NP_001340928.1  lysine-specific demethylase 4C isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL137020, AL161443, AL354707, AL445592, AL513412
      UniProtKB/TrEMBL
      C9J879
      Conserved Domains (3) summary
      smart00333
      Location:475 → 529
      TUDOR; Tudor domain
      cd15577
      Location:207 → 309
      PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
      cl22851
      Location:318 → 427
      PHD_SF; PHD finger superfamily

    9. NM_001354000.3 → NP_001340929.1  lysine-specific demethylase 4C isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL137020, AL161443, AL354707, AL445592, AL513412
      UniProtKB/TrEMBL
      C9J879
      Conserved Domains (3) summary
      smart00333
      Location:442 → 496
      TUDOR; Tudor domain
      cd15577
      Location:207 → 309
      PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
      cl22851
      Location:318 → 427
      PHD_SF; PHD finger superfamily

    10. NM_001354001.3 → NP_001340930.1  lysine-specific demethylase 4C isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL137020, AL161443, AL354707, AL445592, AL513412
      UniProtKB/TrEMBL
      C9J879
      Conserved Domains (3) summary
      smart00333
      Location:442 → 496
      TUDOR; Tudor domain
      cd15577
      Location:207 → 309
      PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
      cl22851
      Location:318 → 427
      PHD_SF; PHD finger superfamily

    11. NM_015061.6 → NP_055876.2  lysine-specific demethylase 4C isoform 1

      See identical proteins and their annotated locations for NP_055876.2

      Status: REVIEWED

      Source sequence(s)
      AL137020, AL161443, AL354707, AL445592, AL513412
      Consensus CDS
      CCDS6471.1
      UniProtKB/Swiss-Prot
      B4E1Y4, B7ZL46, F5H347, F5H7P0, O94877, Q2M3M0, Q5JUC9, Q5VYJ2, Q5VYJ3, Q9H3R0
      Related
      ENSP00000370710.3, ENST00000381309.8
      Conserved Domains (5) summary
      smart00333
      Location:879 → 933
      TUDOR; Tudor domain
      pfam02373
      Location:177 → 293
      JmjC; JmjC domain, hydroxylase
      cd15577
      Location:644 → 746
      PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
      cd15715
      Location:755 → 864
      ePHD_JMJD2C; Extended PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
      cl15840
      Location:16 → 57
      JmjN; jmjN domain

    RNA

    1. NR_130707.4 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL354707, AL445592, AL513412
      Related
      ENST00000438023.5

    2. NR_148677.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137020, AL161443, AL354707, AL445592, AL513412

    3. NR_148678.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137020, AL161443, AL354707, AL445592, AL513412

    4. NR_148679.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137020, AL161443, AL354707, AL445592, AL513412

    5. NR_148680.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137020, AL161443, AL354707, AL445592, AL513412

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      6720863..7175648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014498.3 → XP_016869987.1  lysine-specific demethylase 4C isoform X1

      Conserved Domains (5) summary
      smart00333
      Location:878 → 933
      TUDOR; Tudor domain
      pfam02373
      Location:177 → 293
      JmjC; JmjC domain, hydroxylase
      cd15577
      Location:644 → 746
      PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
      cd15715
      Location:755 → 864
      ePHD_JMJD2C; Extended PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
      cl15840
      Location:16 → 57
      JmjN; jmjN domain

    2. XM_047423029.1 → XP_047278985.1  lysine-specific demethylase 4C isoform X2

    3. XM_047423028.1 → XP_047278984.1  lysine-specific demethylase 4C isoform X3

    4. XM_047423027.1 → XP_047278983.1  lysine-specific demethylase 4C isoform X2

    5. XM_047423026.1 → XP_047278982.1  lysine-specific demethylase 4C isoform X2

    6. XM_047423030.1 → XP_047278986.1  lysine-specific demethylase 4C isoform X4

      Related
      ENSP00000405739.2, ENST00000428870.6

    RNA

    1. XR_001746255.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      6715554..7172114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362439.1 → XP_054218414.1  lysine-specific demethylase 4C isoform X1

    2. XM_054362445.1 → XP_054218420.1  lysine-specific demethylase 4C isoform X5

    3. XM_054362443.1 → XP_054218418.1  lysine-specific demethylase 4C isoform X2

    4. XM_054362442.1 → XP_054218417.1  lysine-specific demethylase 4C isoform X3

    5. XM_054362441.1 → XP_054218416.1  lysine-specific demethylase 4C isoform X2

    6. XM_054362440.1 → XP_054218415.1  lysine-specific demethylase 4C isoform X2

    7. XM_054362444.1 → XP_054218419.1  lysine-specific demethylase 4C isoform X4

    RNA

    1. XR_008487968.1 RNA Sequence

    2. XR_008487969.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001146694.1: Suppressed sequence

      Description
      NM_001146694.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H3R0.2 GenPept UniProtKB/Swiss-Prot:Q9H3R0

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