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    APLP2 amyloid beta precursor like protein 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 479393, updated on 5-Mar-2024

    Summary

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    Official Symbol
    APLP2provided by VGNC
    Official Full Name
    amyloid beta precursor like protein 2provided by VGNC
    Primary source
    VGNC:VGNC:37989
    See related
    Ensembl:ENSCAFG00845006750
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See APLP2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (4663992..4746091, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (4764879..4846709, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (4734652..4816738, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (4725302..4807340, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (4706890..4788998, complement)

    Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene ST14 transmembrane serine protease matriptase Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene PR/SET domain 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    amyloid-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051809.1 Reference ROS_Cfam_1.0

      Range
      4663992..4746091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038664384.1 → XP_038520312.1  amyloid-like protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8C0YWP7
      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:309 → 491
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:612 → 692
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    2. XM_038664383.1 → XP_038520311.1  amyloid-like protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0KAU9, A0A8C0YWP7, A0A8C0YWW2, A0A8I3MVF1
      Related
      ENSCAFP00845009415.1, ENSCAFT00845012061.1
      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:309 → 491
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:624 → 704
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    3. XM_038664382.1 → XP_038520310.1  amyloid-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0K856, A0A8C0SDW3, A0A8C0YWP7, A0A8I3N111
      Related
      ENSCAFP00845009483.1, ENSCAFT00845012138.1
      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:668 → 748
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    4. XM_038664381.1 → XP_038520309.1  amyloid-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KAT9, A0A8C0M5I6, A0A8C0YWP7, A0A8I3N3Q6
      Related
      ENSCAFP00845009357.1, ENSCAFT00845011992.1
      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:680 → 760
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049265.1 Alternate UMICH_Zoey_3.1

      Range
      4725302..4807340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038474512.1 → XP_038330440.1  amyloid-like protein 2 isoform X4

      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:309 → 491
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:612 → 692
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    2. XM_038474511.1 → XP_038330439.1  amyloid-like protein 2 isoform X3

      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:309 → 491
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:624 → 704
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    3. XM_038474510.1 → XP_038330438.1  amyloid-like protein 2 isoform X2

      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:668 → 748
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    4. XM_038474509.1 → XP_038330437.1  amyloid-like protein 2 isoform X1

      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:680 → 760
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

      Range
      4706890..4788998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038599841.1 → XP_038455769.1  amyloid-like protein 2 isoform X4

      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:309 → 491
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:612 → 692
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    2. XM_038599840.1 → XP_038455768.1  amyloid-like protein 2 isoform X3

      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:309 → 491
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:624 → 704
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    3. XM_038599839.1 → XP_038455767.1  amyloid-like protein 2 isoform X2

      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:668 → 748
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    4. XM_038599838.1 → XP_038455766.1  amyloid-like protein 2 isoform X1

      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:680 → 760
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

      Range
      4734652..4816738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038535634.1 → XP_038391562.1  amyloid-like protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8C0YWP7
      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:309 → 491
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:612 → 692
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    2. XM_038535633.1 → XP_038391561.1  amyloid-like protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0KAU9, A0A8C0YWP7, A0A8C0YWW2, A0A8I3MVF1
      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:309 → 491
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:624 → 704
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    3. XM_038535632.1 → XP_038391560.1  amyloid-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0K856, A0A8C0SDW3, A0A8C0YWP7, A0A8I3N111
      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:668 → 748
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    4. XM_038535631.1 → XP_038391559.1  amyloid-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KAT9, A0A8C0M5I6, A0A8C0YWP7, A0A8I3N3Q6
      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:680 → 760
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      4764879..4846709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005619552.4 → XP_005619609.1  amyloid-like protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8C0YWP7
      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:309 → 491
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:612 → 692
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    2. XM_005619551.4 → XP_005619608.1  amyloid-like protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0KAU9, A0A8C0YWP7, A0A8C0YWW2, A0A8I3MVF1
      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:309 → 491
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:624 → 704
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    3. XM_005619550.4 → XP_005619607.1  amyloid-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0K856, A0A8C0SDW3, A0A8C0YWP7, A0A8I3N111
      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:668 → 748
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins

    4. XM_536530.7 → XP_536530.2  amyloid-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KAT9, A0A8C0M5I6, A0A8C0YWP7, A0A8I3N3Q6
      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:680 → 760
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    Nucleotide Protein
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