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    Agrp agouti related neuropeptide [ Mus musculus (house mouse) ]

    Gene ID: 11604, updated on 12-May-2024

    Summary

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    Official Symbol
    Agrpprovided by MGI
    Official Full Name
    agouti related neuropeptideprovided by MGI
    Primary source
    MGI:MGI:892013
    See related
    Ensembl:ENSMUSG00000005705 AllianceGenome:MGI:892013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Art; Agrt
    Summary
    This gene encodes a protein that regulates feeding behavior and plays a key role in the control of body weight. The encoded protein acts as an antagonist of melanocortin receptor signaling. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2012]
    Expression
    Ubiquitous expression in testis adult (RPKM 3.2), placenta adult (RPKM 1.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 D3; 8 53.04 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106293327..106306477, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105566695..105579845, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene hydroxysteroid 11-beta dehydrogenase 2 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit D1 Neighboring gene STARR-positive B cell enhancer ABC_E10519 Neighboring gene STARR-positive B cell enhancer ABC_E11395 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108090885-108090994 Neighboring gene predicted gene, 38250 Neighboring gene predicted gene 45855 Neighboring gene RHO family interacting cell polarization regulator 1 Neighboring gene microRNA 1966

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Agouti-related peptide neuronal silencing overcomes delayed puberty in neonatally underfed male mice. Decourt C, et al. J Neuroendocrinol, 2022 Oct. PMID 36306199, Free PMC Article
    2. Rescue of obesity-induced infertility in female mice by silencing AgRP neurons. Bai X, et al. Biochem Biophys Res Commun, 2022 Oct 1. PMID 35870259
    3. NPY derived from AGRP neurons controls feeding via Y1 and energy expenditure and food foraging behaviour via Y2 signalling. Qi Y, et al. Mol Metab, 2022 May. PMID 35167990, Free PMC Article
    4. Metabolic sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum. Reichenbach A, et al. Elife, 2022 Jan 12. PMID 35018884, Free PMC Article
    5. Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding. Han Y, et al. Nat Commun, 2021 Jun 10. PMID 34112797, Free PMC Article

    See all (308) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. microRNA-33 controls hunger signaling in hypothalamic AgRP neurons.
      Title: microRNA-33 controls hunger signaling in hypothalamic AgRP neurons.
    2. Opioidergic signaling contributes to food-mediated suppression of AgRP neurons.
      Title: Opioidergic signaling contributes to food-mediated suppression of AgRP neurons.
    3. AgRP neurons encode circadian feeding time.
      Title: AgRP neurons encode circadian feeding time.
    4. Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency.
      Title: Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency.
    5. AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.
      Title: AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.
    6. Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.
      Title: Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.
    7. Bridging Energy Need and Feeding Behavior: The Impact of eIF2alpha Phosphorylation in AgRP Neurons.
      Title: Bridging Energy Need and Feeding Behavior: The Impact of eIF2α Phosphorylation in AgRP Neurons.
    8. AgRP neurons coordinate the mitigation of activity-based anorexia.
      Title: AgRP neurons coordinate the mitigation of activity-based anorexia.
    9. Agouti-related peptide neuronal silencing overcomes delayed puberty in neonatally underfed male mice.
      Title: Agouti-related peptide neuronal silencing overcomes delayed puberty in neonatally underfed male mice.
    10. Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo.
      Title: Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo.
    Submit: New GeneRIF Correction See all GeneRIFs (102)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Potential readthrough

    Included gene: Gm5914

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide hormone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuropeptide hormone activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables type 1 melanocortin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult feeding behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adult feeding behavior IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in eating behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of feeding behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of feeding behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of feeding behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    agouti-related protein
    Names
    orexigenic neuropeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271806.1 → NP_001258735.1  agouti-related protein precursor

      See identical proteins and their annotated locations for NP_001258735.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC151573, AK138796, BC079902
      Consensus CDS
      CCDS22605.1
      UniProtKB/Swiss-Prot
      O35967, P56473
      UniProtKB/TrEMBL
      A0A0A6YX09, Q3UU47
      Related
      ENSMUSP00000141783.2, ENSMUST00000194654.2
      Conserved Domains (1) summary
      smart00792
      Location:1 → 121
      Agouti; Agouti protein

    2. NM_007427.3 → NP_031453.1  agouti-related protein precursor

      See identical proteins and their annotated locations for NP_031453.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK138796, BC079902, CO044337
      Consensus CDS
      CCDS22605.1
      UniProtKB/Swiss-Prot
      O35967, P56473
      UniProtKB/TrEMBL
      A0A0A6YX09, Q3UU47
      Related
      ENSMUSP00000005849.6, ENSMUST00000005849.11
      Conserved Domains (1) summary
      smart00792
      Location:1 → 121
      Agouti; Agouti protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106293327..106306477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56473.1 GenPept UniProtKB/Swiss-Prot:P56473

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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