Conserved Protein Domain Family
Agouti

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smart00792: Agouti 
Agouti protein
The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP) is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation.
Statistics
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PSSM-Id: 197876
Aligned: 8 rows
Threshold Bit Score: 106.9
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003209718  79 MLNALLLCYGLLQGIQAILTSDlshsplqkmsSGLEEADRARypsLLHKAKELSVELARATPRPDldQMEVQEGDDNLLQ 158 turkey
NP_001011693   1 MLTTMLLSCALLLAMPTMLGAQ----------IGLAPLEGIG---RLDQALFPELQDLGLQPPLK--RTTAERAEEALLQ 65  pig
NP_001157489   6 LFLATLLVSLCFLTAYSHLSPE----------EKPKDDRSLRnnsSMNLLDSPSVSIMALNKKSK--KISRKEAEKKKRS 73  horse
NP_443211      6 LLLATLVGFLCFLTVHSHLVFE----------ETLGDDRSLKsnsSINSLDFSSVSIVALNKKSK--KISRKEAEKRKRS 73  Norway rat
NP_001127775   6 LFLATLLVCLCFLSAYSHLAPE----------EKPRDERNLKnnsSMNLLDFPSVSIVALNKKSK--KISRNEAEKKKRA 73  sheep
NP_001129      1 MLTAAVLSCALLLALPATRGAQ----------MGLAPMEGIR---RPDQALLPELPGLGLRAPLK--KTTAEQAEEDLLQ 65  human
CAH60801       6 llccvllclaccvTVHTHMIIE----------EQNSSNQTTIslqANNQTDAPSVLIVGLSKTPK--KNN------KMEK 67  goldfish
CAF97560       1 MSGTHVLGLLLLFITLSW--AA----------DAAEDARKAD-------------STVCCQGKPR--GLFARQKNSLPQE 53  spotted green p...
XP_003209718 159 KSsvlEPQVLSTALQA---A---GReersSPRRCVRLLESCLGHQIPCCDPCATCYCRFFNAFCYCRKI 221 turkey
NP_001011693  66 QA---EAKALAEVLDP---EgrkAR----SPRRCVRLHESCLGHQVPCCDPCATCYCRFFNAFCYCRKL 124 pig
NP_001157489  74 SK---KKASMTKVARP---R---LL----QPAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVL 129 horse
NP_443211     74 SK---KKASIKKVARP--------P----PPSPCVATRDSCKPPAPACCNPCASCQCRFFGSACTCRVL 127 Norway rat
NP_001127775  74 SK---RKAPMKNVART---R---PP----PPTPCVATRDSCKPPAPACCDPCAFCQCRFFRSACSCRVL 129 sheep
NP_001129     66 -----EAQALAEVLDLqdrE---PR----SSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKL 122 human
CAH60801      68 KQ---KKKFSTHVKRP---P---PP----P--NCVPLWGSCKTPSAACCDQCAFCHCRLFKTVCYCRMG 121 goldfish
CAF97560      54 RR---IPKKKPNLLTP--------------IRRCSRLKDSC-SPYMPCCDPCASCHCRLFNTICNCWKM 104 spotted green pufferfish
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