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    SLC2A5 solute carrier family 2 member 5 [ Homo sapiens (human) ]

    Gene ID: 6518, updated on 5-May-2024

    Summary

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    Official Symbol
    SLC2A5provided by HGNC
    Official Full Name
    solute carrier family 2 member 5provided by HGNC
    Primary source
    HGNC:HGNC:11010
    See related
    Ensembl:ENSG00000142583 MIM:138230; AllianceGenome:HGNC:11010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLUT5; GLUT-5
    Summary
    The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]
    Expression
    Biased expression in duodenum (RPKM 33.7), small intestine (RPKM 25.5) and 8 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p36.23
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (9035106..9094195, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (8568756..8627452, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9095165..9132318, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9046209-9046710 Neighboring gene RNA, 7SL, cytoplasmic 451, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9048516-9049016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9064340-9064868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9064869-9065395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9067816-9068316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9068317-9068817 Neighboring gene solute carrier family 2 member 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 112 Neighboring gene MPRA-validated peak52 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9118073-9118573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 113 Neighboring gene small Cajal body-specific RNA 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9164158-9165134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 114 Neighboring gene MPRA-validated peak53 silencer Neighboring gene G protein-coupled receptor 157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9181680-9182180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9182181-9182681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9196849-9197350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9197351-9197850 Neighboring gene Sharpr-MPRA regulatory region 7425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 119 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:9211645-9211881 Neighboring gene MIR34A host gene Neighboring gene microRNA 34a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do not contribute to clinical presentation of acquired fructose malabsorption. Taneva I, et al. BMC Gastroenterol, 2022 Apr 6. PMID 35387598, Free PMC Article
    2. SLC2A5 Correlated with Immune Infiltration: A Candidate Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma. Luo L, et al. J Immunol Res, 2021. PMID 34604392, Free PMC Article
    3. GLUT5-mediated fructose utilization drives lung cancer growth by stimulating fatty acid synthesis and AMPK/mTORC1 signaling. Chen WL, et al. JCI Insight, 2020 Feb 13. PMID 32051337, Free PMC Article
    4. An essential role for GLUT5-mediated fructose utilization in exacerbating the malignancy of clear cell renal cell carcinoma. Jin X, et al. Cell Biol Toxicol, 2019 Oct. PMID 31102011
    5. SLC2A5 overexpression in childhood philadelphia chromosome-positive acute lymphoblastic leukaemia. Zhao P, et al. Br J Haematol, 2018 Oct. PMID 30272826

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GLUT5: structure, functions, diseases and potential applications.
      Title: GLUT5: structure, functions, diseases and potential applications.
    2. Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells.
      Title: Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells.
    3. Obesity and overweight are linked to increased sodium-glucose cotransporter 1 and glucose transporter 5 levels in duodenum.
      Title: Obesity and overweight are linked to increased sodium-glucose cotransporter 1 and glucose transporter 5 levels in duodenum.
    4. Serum Iba-1, GLUT5, and TSPO in Patients With Diabetic Retinopathy: New Biomarkers for Early Retinal Neurovascular Alterations? A Pilot Study.
      Title: Serum Iba-1, GLUT5, and TSPO in Patients With Diabetic Retinopathy: New Biomarkers for Early Retinal Neurovascular Alterations? A Pilot Study.
    5. GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer.
      Title: GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer.
    6. Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do not contribute to clinical presentation of acquired fructose malabsorption.
      Title: Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do not contribute to clinical presentation of acquired fructose malabsorption.
    7. SLC2A5 Correlated with Immune Infiltration: A Candidate Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma.
      Title: SLC2A5 Correlated with Immune Infiltration: A Candidate Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma.
    8. S100P contributes to promoter demethylation and transcriptional activation of SLC2A5 to promote metastasis in colorectal cancer.
      Title: S100P contributes to promoter demethylation and transcriptional activation of SLC2A5 to promote metastasis in colorectal cancer.
    9. Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems.
      Title: Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems.
    10. GLUT5 regulation by AKT1/3-miR-125b-5p downregulation induces migratory activity and drug resistance in TLR-modified colorectal cancer cells.
      Title: GLUT5 regulation by AKT1/3-miR-125b-5p downregulation induces migratory activity and drug resistance in TLR-modified colorectal cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fructose binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fructose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fructose transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables glucose transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to fructose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fructose import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fructose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose transmembrane transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in intestinal hexose absorption TAS
    Traceable Author Statement
    more info
    		  
    involved_in regulation of systemic arterial blood pressure mediated by a chemical signal ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to fructose ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in sarcolemma ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 5
    Names
    glucose transporter type 5, small intestine
    glucose transporter-like protein 5
    solute carrier family 2 (facilitated glucose/fructose transporter), member 5
    testicular tissue protein Li 81

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050918.1 RefSeqGene

      Range
      28773..63302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001135585.2 → NP_001129057.1  solute carrier family 2, facilitated glucose transporter member 5 isoform 2

      See identical proteins and their annotated locations for NP_001129057.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL158048, BC035878, DC379829
      Consensus CDS
      CCDS44054.1
      UniProtKB/TrEMBL
      A0A140VJK5
      Related
      ENSP00000366631.3, ENST00000377414.7
      Conserved Domains (1) summary
      cl26863
      Location:23 → 194
      Sugar_tr; Sugar (and other) transporter

    2. NM_001328619.2 → NP_001315548.1  solute carrier family 2, facilitated glucose transporter member 5 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AL158048
      Consensus CDS
      CCDS99.1
      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3
      UniProtKB/TrEMBL
      B4DXN5
      Conserved Domains (1) summary
      pfam00083
      Location:23 → 475
      Sugar_tr; Sugar (and other) transporter

    3. NM_001328620.2 → NP_001315549.1  solute carrier family 2, facilitated glucose transporter member 5 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL158048
      UniProtKB/TrEMBL
      B4DG19, B4DXM7
      Conserved Domains (2) summary
      cd06174
      Location:28 → 416
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:22 → 431
      Sugar_tr; Sugar (and other) transporter

    4. NM_001328621.2 → NP_001315550.1  solute carrier family 2, facilitated glucose transporter member 5 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks three alternate coding exons compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL158048
      UniProtKB/TrEMBL
      B4DU31

    5. NM_003039.3 → NP_003030.1  solute carrier family 2, facilitated glucose transporter member 5 isoform 1

      See identical proteins and their annotated locations for NP_003030.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AL158048, CA309754, DC379829, M55531
      Consensus CDS
      CCDS99.1
      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3
      UniProtKB/TrEMBL
      B4DXN5
      Related
      ENSP00000366641.4, ENST00000377424.9
      Conserved Domains (1) summary
      pfam00083
      Location:23 → 475
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      9035106..9094195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428615.1 → XP_047284571.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    2. XM_047428614.1 → XP_047284570.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    3. XM_047428606.1 → XP_047284562.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    4. XM_047428612.1 → XP_047284568.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    5. XM_047428602.1 → XP_047284558.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    6. XM_047428623.1 → XP_047284579.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X2

    7. XM_047428588.1 → XP_047284544.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    8. XM_047428594.1 → XP_047284550.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    9. XM_047428598.1 → XP_047284554.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    10. XM_047428591.1 → XP_047284547.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    11. XM_047428625.1 → XP_047284581.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X3

      UniProtKB/TrEMBL
      B4DT82

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      8568756..8627452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338404.1 → XP_054194379.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    2. XM_054338405.1 → XP_054194380.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    3. XM_054338403.1 → XP_054194378.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    4. XM_054338406.1 → XP_054194381.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X2

    5. XM_054338399.1 → XP_054194374.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    6. XM_054338401.1 → XP_054194376.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    7. XM_054338402.1 → XP_054194377.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    8. XM_054338400.1 → XP_054194375.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

      UniProtKB/Swiss-Prot
      P22732, Q14770, Q5T977, Q8IVB3

    9. XM_054338407.1 → XP_054194382.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X3

      UniProtKB/TrEMBL
      B4DT82

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_024180.1: Suppressed sequence

      Description
      NR_024180.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22732.1 GenPept UniProtKB/Swiss-Prot:P22732

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