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    Slc35b1 solute carrier family 35, member B1 [ Mus musculus (house mouse) ]

    Gene ID: 110172, updated on 12-May-2024

    Summary

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    Official Symbol
    Slc35b1provided by MGI
    Official Full Name
    solute carrier family 35, member B1provided by MGI
    Primary source
    MGI:MGI:1343133
    See related
    Ensembl:ENSMUSG00000020873 AllianceGenome:MGI:1343133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AXER; Ugalt2; UGTrel1
    Summary
    Predicted to enable UDP-galactose transmembrane transporter activity and UDP-glucose transmembrane transporter activity. Predicted to be involved in UDP-galactose transmembrane transport. Predicted to act upstream of or within carbohydrate transport. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be integral component of Golgi membrane and integral component of endoplasmic reticulum membrane. Is expressed in genitourinary system; jaw; skeleton; and submandibular gland primordium. Orthologous to human SLC35B1 (solute carrier family 35 member B1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 76.5), duodenum adult (RPKM 41.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc35b1 in Genome Data Viewer
    Location:
    11 D; 11 59.01 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95275696..95282602)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95384856..95391776)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1841 Neighboring gene predicted gene 11520 Neighboring gene STARR-seq mESC enhancer starr_30502 Neighboring gene STARR-positive B cell enhancer ABC_E594 Neighboring gene family with sequence similarity 117, member A Neighboring gene STARR-positive B cell enhancer ABC_E3009 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:95253828-95254029 Neighboring gene STARR-seq mESC enhancer starr_30505 Neighboring gene STARR-positive B cell enhancer ABC_E3010 Neighboring gene STARR-positive B cell enhancer ABC_E10708 Neighboring gene speckle-type BTB/POZ protein Neighboring gene predicted gene, 53646

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family. Ishida N, et al. J Biochem, 1996 Dec. PMID 9010752
    2. The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Lennon G, et al. Genomics, 1996 Apr 1. PMID 8617505
    3. Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad. McClive PJ, et al. Genesis, 2003 Oct. PMID 14595844
    4. A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. Dai FF, et al. J Biol Chem, 2015 Oct 9. PMID 26272612, Free PMC Article
    5. Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. Mohlke KL, et al. Genomics, 1998 Nov 15. PMID 9806826

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP:ADP antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP-galactose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-galactose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 35 member B1
    Names
    ATP/ADP exchanger ER
    UDP-galactose translocator 2
    UDP-galactose transporter-related protein 1
    endoplasmic reticulum ATP/ADP translocase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357797.2 → NP_001344726.1  solute carrier family 35 member B1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL662875
      Conserved Domains (1) summary
      pfam08449
      Location:1 → 212
      UAA; UAA transporter family

    2. NM_016752.4 → NP_058032.3  solute carrier family 35 member B1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL662875
      Consensus CDS
      CCDS25277.1
      UniProtKB/Swiss-Prot
      P97858, Q8CF70
      Related
      ENSMUSP00000021243.10, ENSMUST00000021243.16
      Conserved Domains (1) summary
      pfam08449
      Location:16 → 309
      UAA; UAA transporter family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      95275696..95282602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531986.3 → XP_006532049.1  solute carrier family 35 member B1 isoform X1

      Conserved Domains (1) summary
      pfam08449
      Location:1 → 185
      UAA; UAA transporter family

    2. XM_030245471.1 → XP_030101331.1  solute carrier family 35 member B1 isoform X1

      Conserved Domains (1) summary
      pfam08449
      Location:1 → 185
      UAA; UAA transporter family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97858.1 GenPept UniProtKB/Swiss-Prot:P97858

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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