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    OGA O-GlcNAcase [ Homo sapiens (human) ]

    Gene ID: 10724, updated on 2-May-2024

    Summary

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    Official Symbol
    OGAprovided by HGNC
    Official Full Name
    O-GlcNAcaseprovided by HGNC
    Primary source
    HGNC:HGNC:7056
    See related
    Ensembl:ENSG00000198408 MIM:604039; AllianceGenome:HGNC:7056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MEA5; MGEA5; NCOAT
    Summary
    The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in brain (RPKM 42.8), lymph node (RPKM 37.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    10q24.32
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (101784450..101818444, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (102667945..102701933, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103544207..103578201, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103529890-103530667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103534038-103534776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103534777-103535515 Neighboring gene FGF8 5' regulatory region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103542131-103542770 Neighboring gene fibroblast growth factor 8 Neighboring gene nucleophosmin/nucleoplasmin 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103577734-103578309 Neighboring gene Sharpr-MPRA regulatory region 4495 Neighboring gene KCNIP2 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103587343-103588542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2731 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103590597-103591113 Neighboring gene Sharpr-MPRA regulatory region 3638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103596213-103596713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2733 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103603069-103603574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2734 Neighboring gene potassium voltage-gated channel interacting protein 2 Neighboring gene uncharacterized LOC101927445 Neighboring gene armadillo like helical domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair. Cui Y, et al. Cell Death Dis, 2021 Jun 16. PMID 34135314, Free PMC Article
    2. Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of α-synuclein preformed fibrils. Tavassoly O, et al. FEBS J, 2021 Jan. PMID 32365408
    3. Proteomic analysis of the OGT interactome: novel links to epithelial-mesenchymal transition and metastasis of cervical cancer. Gao J, et al. Carcinogenesis, 2018 Oct 8. PMID 30052810, Free PMC Article
    4. Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase. Li B, et al. Nat Commun, 2017 Sep 22. PMID 28939839, Free PMC Article
    5. The Sulfur-Linked Analogue of O-GlcNAc (S-GlcNAc) Is an Enzymatically Stable and Reasonable Structural Surrogate for O-GlcNAc at the Peptide and Protein Levels. De Leon CA, et al. Biochemistry, 2017 Jul 11. PMID 28627871, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex.
      Title: Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex.
    2. Inhibition of O-GlcNAcase Inhibits Hematopoietic and Leukemic Stem Cell Self-Renewal and Drives Dendritic Cell Differentiation via STAT3/5 Signaling.
      Title: Inhibition of O-GlcNAcase Inhibits Hematopoietic and Leukemic Stem Cell Self-Renewal and Drives Dendritic Cell Differentiation via STAT3/5 Signaling.
    3. Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice.
      Title: Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice.
    4. OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.
      Title: OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.
    5. Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of alpha-synuclein preformed fibrils.
      Title: Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of α-synuclein preformed fibrils.
    6. Elucidating the protein substrate recognition of O-GlcNAc transferase (OGT) toward O-GlcNAcase (OGA) using a GlcNAc electrophilic probe.
      Title: Elucidating the protein substrate recognition of O-GlcNAc transferase (OGT) toward O-GlcNAcase (OGA) using a GlcNAc electrophilic probe.
    7. Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
      Title: Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
    8. Study reports that OGA is upregulated in a wide range of human cancers and drives aerobic glycolysis and tumor growth by inhibiting pyruvate kinase M2 (PKM2). PKM2 is dynamically O-GlcNAcylated in response to changes in glucose availability. Under high glucose conditions, PKM2 is a target of OGA-associated acetyltransferase activity, which facilitates O-GlcNAcylation of PKM2 by O-GlcNAc transferase (OGT).
      Title: O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth.
    9. role of the tubular biomarkers NAG, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in patients with chest pain before contrast media exposition
      Title: The role of the tubular biomarkers NAG, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in patients with chest pain before contrast media exposition.
    10. OGT promotes carcinogenesis and metastasis of cervical cancer cells. OGT's expression is significantly upregulated in cervical cancer, and low OGT level is correlated with improved prognosis
      Title: Proteomic analysis of the OGT interactome: novel links to epithelial-mesenchymal transition and metastasis of cervical cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11229, FLJ23355, KIAA0679

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-N-acetylglucosaminidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hyalurononglucosaminidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycoprotein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in glycoprotein metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein deglycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein O-GlcNAcase
    Names
    N-acetyl-beta-D-glucosaminidase
    N-acetyl-beta-glucosaminidase
    beta-N-acetylglucosaminidase
    beta-N-acetylhexosaminidase
    beta-hexosaminidase
    bifunctional protein NCOAT
    hyaluronidase in meningioma
    meningioma expressed antigen 5 (hyaluronidase)
    meningioma-expressed antigen 5
    nuclear cytoplasmic O-GlcNAcase and acetyltransferase
    NP_001135906.1
    NP_036347.1
    XP_047280470.1
    XP_047280471.1
    XP_047280472.1
    XP_047280473.1
    XP_047280474.1
    XP_054220599.1
    XP_054220600.1
    XP_054220601.1
    XP_054220602.1
    XP_054220603.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142434.2 → NP_001135906.1  protein O-GlcNAcase isoform b

      See identical proteins and their annotated locations for NP_001135906.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AC010789
      Consensus CDS
      CCDS44471.1
      UniProtKB/Swiss-Prot
      O60502
      Related
      ENSP00000409973.1, ENST00000439817.5
      Conserved Domains (1) summary
      pfam07555
      Location:62 → 338
      NAGidase; beta-N-acetylglucosaminidase

    2. NM_012215.5 → NP_036347.1  protein O-GlcNAcase isoform a

      See identical proteins and their annotated locations for NP_036347.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC010789
      Consensus CDS
      CCDS7520.1
      UniProtKB/Swiss-Prot
      B7WPB9, D3DR79, E9PGF9, O60502, O75166, Q86WV0, Q8IV98, Q9BVA5, Q9HAR0
      Related
      ENSP00000354850.3, ENST00000361464.8
      Conserved Domains (1) summary
      pfam07555
      Location:62 → 338
      NAGidase; beta-N-acetylglucosaminidase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      101784450..101818444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424515.1 → XP_047280471.1  protein O-GlcNAcase isoform X2

    2. XM_047424514.1 → XP_047280470.1  protein O-GlcNAcase isoform X1

    3. XM_047424516.1 → XP_047280472.1  protein O-GlcNAcase isoform X3

    4. XM_047424518.1 → XP_047280474.1  protein O-GlcNAcase isoform X5

      Related
      ENSP00000359112.3, ENST00000370094.7

    5. XM_047424517.1 → XP_047280473.1  protein O-GlcNAcase isoform X4

    RNA

    1. XR_007061939.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      102667945..102701933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364625.1 → XP_054220600.1  protein O-GlcNAcase isoform X2

    2. XM_054364624.1 → XP_054220599.1  protein O-GlcNAcase isoform X1

    3. XM_054364626.1 → XP_054220601.1  protein O-GlcNAcase isoform X3

    4. XM_054364628.1 → XP_054220603.1  protein O-GlcNAcase isoform X5

    5. XM_054364627.1 → XP_054220602.1  protein O-GlcNAcase isoform X4

    RNA

    1. XR_008488157.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60502.2 GenPept UniProtKB/Swiss-Prot:O60502

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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