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    Kyat1 kynurenine aminotransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 70266, updated on 12-May-2024

    Summary

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    Official Symbol
    Kyat1provided by MGI
    Official Full Name
    kynurenine aminotransferase 1provided by MGI
    Primary source
    MGI:MGI:1917516
    See related
    Ensembl:ENSMUSG00000039648 AllianceGenome:MGI:1917516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gtk; Kat1; KatI; Ccbl1; 2010009K05Rik
    Summary
    Predicted to enable cysteine-S-conjugate beta-lyase activity; protein homodimerization activity; and transaminase activity. Acts upstream of or within response to bacterium. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Orthologous to human KYAT1 (kynurenine aminotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver adult (RPKM 63.7), liver E18 (RPKM 19.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 21.31 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30075136..30096307, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30185124..30206295, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 31080 Neighboring gene STARR-positive B cell enhancer ABC_E2609 Neighboring gene endonuclease G Neighboring gene SPOUT domain containing methyltransferase 1 Neighboring gene predicted gene, 31201 Neighboring gene STARR-seq mESC enhancer starr_04089 Neighboring gene STARR-seq mESC enhancer starr_04090 Neighboring gene RIKEN cDNA 1700084E18 gene Neighboring gene STARR-positive B cell enhancer ABC_E7804 Neighboring gene STARR-seq mESC enhancer starr_04091 Neighboring gene leucine rich repeat containing 8A VRAC subunit A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate. Nadvi NA, et al. Protein Sci, 2017 Apr. PMID 28097769, Free PMC Article
    2. Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases. Han Q, et al. BMC Biochem, 2010 May 19. PMID 20482848, Free PMC Article
    3. Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family. Yu P, et al. Gene, 2006 Jan 3. PMID 16376499
    4. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    5. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-S-conjugate beta-lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutamine-phenylpyruvate transaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kynurenine-oxoglutarate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kynurenine-oxoglutarate transaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-kynurenine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kynurenine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyruvate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kynurenine--oxoglutarate transaminase 1
    Names
    cysteine conjugate-beta lyase 1
    cysteine-S-conjugate beta-lyase
    cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)
    glutamine transaminase K
    glutamine--phenylpyruvate transaminase
    kynurenine aminotransferase I
    kynurenine--oxoglutarate transaminase I
    NP_001343403.1
    NP_001343404.1
    NP_765992.2
    XP_006498378.1
    XP_006498380.1
    XP_030107921.1
    XP_036018454.1
    XP_036018455.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356474.1 → NP_001343403.1  kynurenine--oxoglutarate transaminase 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AI182306, AK088404, AL845258
      Consensus CDS
      CCDS15874.1
      UniProtKB/Swiss-Prot
      Q8BTY1, Q8BY27
      UniProtKB/TrEMBL
      A2AQY9, Q05CI8
      Related
      ENSMUSP00000038612.4, ENSMUST00000044038.10
      Conserved Domains (1) summary
      cl27741
      Location:23 → 420
      Aminotran_1_2; Aminotransferase class I and II

    2. NM_001356475.1 → NP_001343404.1  kynurenine--oxoglutarate transaminase 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AK031511, AL845258
      UniProtKB/TrEMBL
      A2AQY9
      Related
      ENSMUST00000148555.8
      Conserved Domains (1) summary
      PRK08912
      Location:3 → 362
      PRK08912; aminotransferase

    3. NM_172404.3 → NP_765992.2  kynurenine--oxoglutarate transaminase 1 isoform a

      See identical proteins and their annotated locations for NP_765992.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL845258
      Consensus CDS
      CCDS15874.1
      UniProtKB/Swiss-Prot
      Q8BTY1, Q8BY27
      UniProtKB/TrEMBL
      A2AQY9, Q05CI8
      Related
      ENSMUSP00000109293.3, ENSMUST00000113663.9
      Conserved Domains (1) summary
      cl27741
      Location:23 → 420
      Aminotran_1_2; Aminotransferase class I and II

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30075136..30096307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498315.2 → XP_006498378.1  kynurenine--oxoglutarate transaminase 1 isoform X1

      Conserved Domains (1) summary
      PRK08912
      Location:218 → 569
      PRK08912; aminotransferase

    2. XM_030252061.2 → XP_030107921.1  kynurenine--oxoglutarate transaminase 1 isoform X4

      UniProtKB/TrEMBL
      A2AQY8
      Conserved Domains (1) summary
      PRK08912
      Location:2 → 333
      PRK08912; aminotransferase

    3. XM_036162561.1 → XP_036018454.1  kynurenine--oxoglutarate transaminase 1 isoform X3

      UniProtKB/TrEMBL
      A2AQY9
      Conserved Domains (1) summary
      PRK08912
      Location:3 → 362
      PRK08912; aminotransferase

    4. XM_036162562.1 → XP_036018455.1  kynurenine--oxoglutarate transaminase 1 isoform X4

      UniProtKB/TrEMBL
      A2AQY8
      Conserved Domains (1) summary
      PRK08912
      Location:2 → 333
      PRK08912; aminotransferase

    5. XM_006498317.4 → XP_006498380.1  kynurenine--oxoglutarate transaminase 1 isoform X2

      Conserved Domains (1) summary
      PRK08912
      Location:25 → 391
      PRK08912; aminotransferase

    RNA

    1. XR_003953717.1 RNA Sequence

    2. XR_001783175.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTY1.1 GenPept UniProtKB/Swiss-Prot:Q8BTY1

    Gene LinkOut

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