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    Btbd6 BTB domain containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 399566, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Btbd6provided by MGI
    Official Full Name
    BTB domain containing 6provided by MGI
    Primary source
    MGI:MGI:3026623
    See related
    Ensembl:ENSMUSG00000002803 AllianceGenome:MGI:3026623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in neurogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human BTBD6 (BTB domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 15.5), ovary adult (RPKM 14.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 F1; 12 61.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112937880..112943113)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112974260..112979493)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene jagged 2 Neighboring gene microRNA 6941 Neighboring gene STARR-positive B cell enhancer ABC_E11526 Neighboring gene STARR-seq mESC enhancer starr_33372 Neighboring gene nudix hydrolase 14 Neighboring gene BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit Neighboring gene RIKEN cDNA 9230104M06 gene Neighboring gene STARR-positive B cell enhancer ABC_E1866 Neighboring gene phosphofurin acidic cluster sorting protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114285178-114285287 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114285299-114285486

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein 6
    Names
    BTB (POZ) domain containing 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145900.1 → NP_001139372.1  BTB/POZ domain-containing protein 6 isoform 2

      See identical proteins and their annotated locations for NP_001139372.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AA870939, AI118479, AI119004, AK146991
      Consensus CDS
      CCDS49194.1
      UniProtKB/Swiss-Prot
      Q8K2J9
      Related
      ENSMUSP00000127286.2, ENSMUST00000165079.8
      Conserved Domains (3) summary
      cd18349
      Location:78 → 186
      BTB_POZ_BTBD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6)
      cd18525
      Location:186 → 280
      BACK_BTBD6; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6)
      pfam08005
      Location:343 → 486
      PHR; PHR domain

    2. NM_201646.2 → NP_964008.2  BTB/POZ domain-containing protein 6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_964008.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA870939, AI118479, AK146991, BY337984
      Consensus CDS
      CCDS49193.1
      UniProtKB/Swiss-Prot
      Q3UIB3, Q8K2J9
      UniProtKB/TrEMBL
      G5E817
      Related
      ENSMUSP00000002880.7, ENSMUST00000002880.7
      Conserved Domains (4) summary
      smart00225
      Location:138 → 237
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:243 → 349
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:130 → 233
      BTB; BTB/POZ domain
      pfam08005
      Location:394 → 537
      PHR; PHR domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      112937880..112943113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315125.2 → XP_017170614.1  BTB/POZ domain-containing protein 6 isoform X3

      Conserved Domains (3) summary
      cd18525
      Location:76 → 170
      BACK_BTBD6; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6)
      cl38908
      Location:24 → 76
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam08005
      Location:233 → 376
      PHR; PHR domain

    2. XM_006516056.4 → XP_006516119.1  BTB/POZ domain-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006516119.1

      UniProtKB/Swiss-Prot
      Q8K2J9
      Conserved Domains (3) summary
      cd18349
      Location:78 → 186
      BTB_POZ_BTBD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6)
      cd18525
      Location:186 → 280
      BACK_BTBD6; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6)
      pfam08005
      Location:343 → 486
      PHR; PHR domain

    3. XM_017315126.2 → XP_017170615.1  BTB/POZ domain-containing protein 6 isoform X2

      Conserved Domains (3) summary
      cd18525
      Location:69 → 163
      BACK_BTBD6; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6)
      cl38908
      Location:1 → 69
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam08005
      Location:225 → 370
      PHR; PHR domain

    4. XM_017315127.1 → XP_017170616.1  BTB/POZ domain-containing protein 6 isoform X2

      Conserved Domains (3) summary
      cd18525
      Location:69 → 163
      BACK_BTBD6; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6)
      cl38908
      Location:1 → 69
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam08005
      Location:225 → 370
      PHR; PHR domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2J9.3 GenPept UniProtKB/Swiss-Prot:Q8K2J9

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