3NO8,3GBW,3HWJ


Conserved Protein Domain Family
PHR
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pfam08005: PHR (this model, PSSM-Id:400388 is obsolete and has been replaced by 462339)
PHR domain
This domain is called PHR as it was originally found in the proteins PAM, highwire, and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.
Links
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Statistics
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PSSM-Id: 400388
Aligned: 68 rows
Threshold Bit Score: 92.6761
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3NO8_A                   18 NRFQQVESR--WGYSGTs-DRIRFSVNK-RIFVVGFGLYGSIHGptdYQVNIQI--------------IHTD----SNTV 75  
XP_021208186           1694 SRFMRVNQSraWNTGNGspDAICFTVDRsGVMLVGVCVYGGPGN---YEYSIELlndvrqsrsspeemNPAHcwvsVEVA 1770 dom...
Q17DS0                 1648 NRFAKVDVSktWNTGNFgpDAIAFTVDRpGISIAGACVYSGSGS---YEYQLELlydsm-----esksQLQHkwevIESV 1719 yel...
WGS:AAAB:AGAP011177-PA 1672 SRFGKVDLGktWNTGNFgpDAIAFTVDRaGISIVGACVYSGSGS---YEYQLELlydshhs-thshtySHSHrwevLESI 1747 Ano...
EFA00364               1687 SRFTRTNQSrtWNTGNGspDAICFQVDRpGISIAGVGVYGGIGH---YEYELELledqssl-sgseshTHTQrwnsLEIT 1762 red...
XP_016657889            186 SRFAKINQTktWNAGNGspDAICFWVDRaGIAIAGCGVFAGIGN---YDYELELlaekkq---lefdePHGNrwksLIVT 259  pea...
XP_003691571            199 SRFTRVNQTrsWNTGNGspDAICFSVDRpGIAIAGVGIYGGVGM---YDYELELlddqnn---tgndpSHTQrwssLDFT 272  lit...
XP_019928467           1588 NRFTRTSQHamWNSGNGspDAITFSVDKpGILVAGVCVYGGDGQ---YNYELELlddqgd---ginnpSPSQrwnvIESV 1661 Pac...
EFX74318               1736 SRFTSSSQNrsWNTGNGspDAICFTVDRpNVSVIGVGVFGGGGS---YTYELELlelasf---siddaAQTLswhsLAVV 1809 com...
XP_002430461           2128 SRFMRTNQTrtWNTGNGspDAICFSVDKpGVVIAGACVYGGMGV---LEYELELlddqsn--sacgdpSPAQrwttLEVI 2202 hum...

3NO8_A                   76 LGQNDTGFScdgSAS-TFRVMFKEPVEVLPNVNYTACATLKGPD-SHYGTKGMRKVTH-ESpttgaKTcFTFCYAAGNNN 152 
XP_021208186           1771 HGAFSGAEC---QHD-MVQLKFDRPILLKEEIRYAIRLCNHGGr-TANGDCGLPSVKGpDG------TtFRFASCSLSFN 1839 dom...
Q17DS0                 1720 VGAYEQSMV---KNF-MTEIKFDRAINIKENVRYALRLCSQGAr-TCSGDGGFAAIRGpCG------VtFKFYPCDLSFN 1788 yel...
WGS:AAAB:AGAP011177-PA 1748 VGSYDQTAV---RQH-MAELRFNRAVLLKENHRYALRLCSQGAr-TLSGDCGQSSLRGpCG-----TVtFRFYPCDLSFN 1817 Ano...
EFA00364               1763 RGSFVPEDF---APD-IIEIKFDRAVPIKENIKYAIRLRNHGGR-TNNGDGGLNSVKGsDN------TtFTFSTCSLSFN 1831 red...
XP_016657889            260 RGSFGPDDS---AMNyVADLKFDHPIRIKERVKYAIRLRNYGGr-TNNGDMGLSCVKGhDN------TlFSFNTCSLSLN 329  pea...
XP_003691571            273 RGTFGPDDC---VND-IVELKFDKPVPIKENMKYAIRLRNRGGr-TSNGDVGLSVVKGpDG------TtFTFTACSLSFN 341  lit...
XP_019928467           1662 KGAYGHDDC---VND-IAEIKFERPIAIKEGMKYTLRLKNHGSMrTLNGDGGIAKVRCpDG------TnFSFQACSLSTN 1731 Pac...
EFX74318               1810 RGSYGPEDS---IND-VAEIKFDRPVPIKENTRYTFRLRNQGGk-THNGDGGVLSIKGpDG------TtFNFSACLLSFN 1878 com...
XP_002430461           2203 KGTFGPDDC---VSD-IAELKFAKPVPIKENVKYAIRLRNQGGr-TSNGDGGLNTVKGpDG------ItFSFSTCSLSFN 2271 hum...

3NO8_A                  153 GTSVEDGQIPEVIFY 167 
XP_021208186           1840 GTTLARGQIPCLVYY 1854 domestic silkworm
Q17DS0                 1789 GTTPSRGQIPCILYY 1803 yellow fever mosquito
WGS:AAAB:AGAP011177-PA 1818 GTTPARGQIPAILYY 1832 Anopheles gambiae str. PEST
EFA00364               1832 GTTLTRGQIPVILYY 1846 red flour beetle
XP_016657889            330 GTTQSRGQIPYILYY 344  pea aphid
XP_003691571            342 GTTQTRGQIPHILYY 356  little honeybee
XP_019928467           1732 GTNHMRGQIPQILYY 1746 Pacific oyster
EFX74318               1879 GTNHIRGQLPYILYc 1893 common water flea
XP_002430461           2272 GTTQTRGQIPQILYY 2286 human body louse
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