TRIM14 tripartite motif containing 14 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM14provided by HGNC
Official Full Name: tripartite motif containing 14provided by HGNC
Primary source: HGNC:HGNC:16283
See related: Ensembl:ENSG00000106785 MIM:606556; AllianceGenome:HGNC:16283
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Expression: Ubiquitous expression in colon (RPKM 8.0), small intestine (RPKM 7.7) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q22.33

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (98035797..98119222, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (110207739..110291169, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (100846635..100881504, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM14 Overexpression Induces Chemoresistance and Malignant Behaviors of Hepatocellular Carcinoma Cells by Activating the STAT3/HIF-1alpha Pathway.
Title: TRIM14 Overexpression Induces Chemoresistance and Malignant Behaviors of Hepatocellular Carcinoma Cells by Activating the STAT3/HIF-1α Pathway.
Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis.
Title: Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis.
Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway.
Title: Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway.
miR-671-5p repressed progression of papillary thyroid carcinoma via TRIM14.
Title: miR-671-5p repressed progression of papillary thyroid carcinoma via TRIM14.
Human TRIM14 protects transgenic mice from influenza A viral infection without activation of other innate immunity pathways.
Title: Human TRIM14 protects transgenic mice from influenza A viral infection without activation of other innate immunity pathways.
miR-4443 targets TRIM14 to suppress metastasis and energy metabolism of papillary thyroid carcinoma (PTC) in vitro.
Title: miR-4443 targets TRIM14 to suppress metastasis and energy metabolism of papillary thyroid carcinoma (PTC) in vitro.
Trim14 promotes autophagy and chemotherapy resistance of gastric cancer cells by regulating AMPK/mTOR pathway.
Title: Trim14 promotes autophagy and chemotherapy resistance of gastric cancer cells by regulating AMPK/mTOR pathway.
TRIM14 regulates melanoma malignancy via PTEN/PI3K/AKT and STAT3 pathways.
Title: TRIM14 regulates melanoma malignancy via PTEN/PI3K/AKT and STAT3 pathways.
TRIM14 may be a prognostic factor and oncogene in papillary thyroid carcinoma
Title: Tripartite motif containing 14: An oncogene in papillary thyroid carcinoma.
The crystal structure of the TRIM14 PRYSPRY domain was solved, and found a positively charged surface that may mediate its partner specificity. TRIM14 PRYSPRY domain binds to acidic peptides, and the analysis of the reported partners of TRIM14 is consistent with this assumption.
Title: The TRIM14 PRYSPRY domain mediates protein interaction via its basic interface.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

TRIM14_3750 (e-PCR)
- UniSTS:462597

D11S2921 (e-PCR)
- UniSTS:152074

SHGC-148909 (e-PCR)
- UniSTS:173069

D2S1263 (e-PCR)
- UniSTS:36922

D9S1703 (e-PCR)
- UniSTS:64345

RH71443 (e-PCR)
- UniSTS:18281

STS-N37069 (e-PCR)
- UniSTS:29582

D16S325 (e-PCR)
- UniSTS:147089

RH25352 (e-PCR)
- UniSTS:84934

A008O24 (e-PCR)
- UniSTS:60640

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tripartite motif-containing protein 14

Names: tripartite motif protein TRIM14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014788.4 → NP_055603.2 tripartite motif-containing protein 14

See identical proteins and their annotated locations for NP_055603.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.

Source sequence(s)

AA469446, AK292825, AL137073, BF797334

Consensus CDS

CCDS6734.1

UniProtKB/Swiss-Prot

A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

Related

ENSP00000344208.2, ENST00000341469.7

Conserved Domains (1) summary

cd13738
Location:269 → 441

SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
NM_033219.3 → NP_150088.1 tripartite motif-containing protein 14

See identical proteins and their annotated locations for NP_150088.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also referred to as alpha) is alternatively spliced in the 3' UTR, compared to variant 1. Both variants encode the same protein.

Source sequence(s)

AA469446, AF220130, AL137073, BF797334

Consensus CDS

CCDS6734.1

UniProtKB/Swiss-Prot

A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

Related

ENSP00000343990.3, ENST00000342043.3

Conserved Domains (1) summary

cd13738
Location:269 → 441

SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

98035797..98119222 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047424162.1 → XP_047280118.1 tripartite motif-containing protein 14 isoform X1

UniProtKB/Swiss-Prot

A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
XM_047424161.1 → XP_047280117.1 tripartite motif-containing protein 14 isoform X1

UniProtKB/Swiss-Prot

A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
XM_047424160.1 → XP_047280116.1 tripartite motif-containing protein 14 isoform X1

UniProtKB/Swiss-Prot

A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

Related

ENSP00000364239.3, ENST00000375098.7
XM_017015353.3 → XP_016870842.1 tripartite motif-containing protein 14 isoform X1

UniProtKB/Swiss-Prot

A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

Conserved Domains (1) summary

cd13738
Location:269 → 441

SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
XM_005252320.5 → XP_005252377.1 tripartite motif-containing protein 14 isoform X1

See identical proteins and their annotated locations for XP_005252377.1

UniProtKB/Swiss-Prot

A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020

Conserved Domains (1) summary

cd13738
Location:269 → 441

SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
XM_047424163.1 → XP_047280119.1 tripartite motif-containing protein 14 isoform X2
XM_047424164.1 → XP_047280120.1 tripartite motif-containing protein 14 isoform X2
XM_011519244.3 → XP_011517546.1 tripartite motif-containing protein 14 isoform X3

Conserved Domains (1) summary

cd13738
Location:112 → 284

SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

RNA

XR_929880.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060933.1 Alternate T2T-CHM13v2.0

Range

110207739..110291169 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054364293.1 → XP_054220268.1 tripartite motif-containing protein 14 isoform X1

UniProtKB/Swiss-Prot

A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
XM_054364292.1 → XP_054220267.1 tripartite motif-containing protein 14 isoform X1

UniProtKB/Swiss-Prot

A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
XM_054364291.1 → XP_054220266.1 tripartite motif-containing protein 14 isoform X1

UniProtKB/Swiss-Prot

A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
XM_054364290.1 → XP_054220265.1 tripartite motif-containing protein 14 isoform X1

UniProtKB/Swiss-Prot

A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
XM_054364289.1 → XP_054220264.1 tripartite motif-containing protein 14 isoform X1

UniProtKB/Swiss-Prot

A8K9W0, E7EQC4, F8W956, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
XM_054364294.1 → XP_054220269.1 tripartite motif-containing protein 14 isoform X2
XM_054364295.1 → XP_054220270.1 tripartite motif-containing protein 14 isoform X2
XM_054364296.1 → XP_054220271.1 tripartite motif-containing protein 14 isoform X3

RNA

XR_008488114.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_033220.1: Suppressed sequence

Description

NM_033220.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
NM_033221.1: Suppressed sequence

Description

NM_033221.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which aligns with poorly supported non-consensus splice sites in the 3' coding region.