Conserved Protein Domain Family
SPRY_PRY_TRIM14
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cd13738: SPRY_PRY_TRIM14 
PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
This is a TRIM14 domain family contains residues in the N-terminus that form a distinct PRY domain structure such that the B30.2 domain consists of PRY and SPRY subdomains. TRIM14 domains have yet to be characterized. These B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. It belongs to Class IV TRIM protein family which has members involved in antiviral immunity at various levels of interferon signaling cascade.
Links
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Statistics
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PSSM-Id: 293973
Aligned: 9 rows
Threshold Bit Score: 315.572
Created: 31-Oct-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_055603    269 PTLDPDTMHARLRLSADRLTVRCGLLGSLGPVPVLRFDALWQVLARDCFATGRHYWEVDVQEAGaGWWVGAAYASLRRRg 348 human
AAI66777     267 PTLDPDTMHARLRLSTDGLTVRCSLLGRLGPRPAPRFDSLRQVLGRDGFAAGRHYWEVDVQEAGvGWWVGAAYPSLRRRg 346 Norway rat
CAG32395     260 PTWEYDSLHPRLKLSDDRLVVSCNWRRIFYPCGPQRFDKLWQVLSRDAFLSGSHYWEVDLLHAGaGWWIGAAYPSIGRKg 339 chicken
XP_007499037 240 PTLEPDTMHPRLRLSDDRLTVTCVWMGKIQLCNPQRFDKLWQVLSRDSFFSGSHYWEVDLLNSGiGWWLGVAYPSIKRKg 319 gray short-tail...
XP_006629806 341 PILDPDTLHPRLRLSESRETVSCGWLKKSYPNGPLRFDRLWQVLGRESFFAGRHYWEVDVQRAGkGWWVGAVYRTMSRKg 420 spotted gar
XP_008502060 275 LTWDYNSLHPRLKLSDDSLVVNRSWRRIFYLCGPQRFDKLWQVLSRNAFLSGSHYWXLDLEHAGaGWWIGTAQPSIGRKg 354 Anna's hummingbird
XP_006008114 362 PTFEPETHHSRLRLSEDRHTVSCAWVRTFFNNHPQRFDKLWQVLSKDSFFSGCHYWEVDLLNASqGWWIGVAYPSIKRKg 441 coelacanth
XP_007113938 244 PTLEPDTLHARLRLSADNLKVCCGYHGSLGLNPALHFDALWQVLGRECFDAGRHYWEVDVQEAGvGWWVGAAYSSLXGAs 323 sperm whale
XP_007461726 289 PTLEPDTLHPRMRFWVDRLKVRCGHHCTLGLKPALHFDALWXXXXRDCFDAGRHYWEVDMQEAGvGWWVDAAYGSLXGAs 368 Yangtze River d...

NP_055603    349 asAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTgGMSHLHTFRATFQEPLYPA 428 human
AAI66777     347 tsTAARLGCNRESWCVKRYDMEYWAFHDCQRSRLRLRRDPHRLGVFLDYEAGILTFYDVAgGMSHLHTFYAVFQEPLYPA 426 Norway rat
CAG32395     340 dsESCRLGWNRASWCIKKFDLEYWAFHKGERIPLLIEDDPDRIGVFLDYEAGILSFYNVTdGMTHLHTFRCKFTEPVYPA 419 chicken
XP_007499037 320 nsEASRLGFNRQSWCLKRFDLEYWAFHNGERTRITVDQDPERIGIFLDYEAGILSFYDITcGMSHLHTFRSRFQEPLYPA 399 gray short-tail...
XP_006629806 421 dtEASRLGWNQASWCLKRYDLEYWAFHNGTRTPVFLEEDPERLGIFLDYEAGVLSFFDALlGMRHLYTFQARFTEPVYPA 500 spotted gar
XP_008502060 355 dsETCQLGWNXASWFLKKFDFENWVFQKRERTPILIEDNPDRTGVFRDYEAGILSFXSVTdGMTHLHPFCSTFTDPVYPA 434 Anna's hummingbird
XP_006008114 442 dtEHSRLGWNRRSWCIKRFDMEYWAFHNGLRIPLLVEEDPEIIGVFLDYEAGTLSFYDVVcKRRHLYTFHAKFTEPLYPA 521 coelacanth
XP_007113938 324 --AAARLGCNRQSWCLELYDLEYWVFHDGQRSRLRPRDDPDRLRVFLDYEVGVFIFYDVTgGMTHLHTFRAALQKLLYPA 401 sperm whale
XP_007461726 369 --AAARLGCNCQSCCLELYDLEYWAFHDGQRSRLRPRDDPDRRGVFLDYEVGVFTFYDVX-GMIHLHTFRAAFQALLYPA 445 Yangtze River d...

NP_055603    429 LRLWEGAISIPRL 441 human
AAI66777     427 LRLWEGTISIPRL 439 Norway rat
CAG32395     420 LRLWEGSIGIWKL 432 chicken
XP_007499037 400 LRLWEGSITILKL 412 gray short-tailed opossum
XP_006629806 501 FRLWEGAISFCKL 513 spotted gar
XP_008502060 435 LRLWGGSTAIHKL 447 Anna's hummingbird
XP_006008114 522 FRLWEGSITLCKL 534 coelacanth
XP_007113938 402 LRLWEGAISISRL 414 sperm whale
XP_007461726 446 LRLWEGAISISRL 458 Yangtze River dolphin
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