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    Gpkow G patch domain and KOW motifs [ Mus musculus (house mouse) ]

    Gene ID: 209416, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gpkowprovided by MGI
    Official Full Name
    G patch domain and KOW motifsprovided by MGI
    Primary source
    MGI:MGI:1859610
    See related
    Ensembl:ENSMUSG00000031148 AllianceGenome:MGI:1859610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T54; DXImx41e; 4432411B18; DXErtd697e
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Orthologous to human GPKOW (G-patch domain and KOW motifs). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.4), CNS E14 (RPKM 5.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A1.1; X 3.47 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7563373..7576500)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7697134..7710261)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene MAGI family member, X-linked Neighboring gene peptidylprolyl isomerase A pseudogene x_14.1 Neighboring gene STARR-seq mESC enhancer starr_46667 Neighboring gene STARR-seq mESC enhancer starr_46668 Neighboring gene STARR-seq mESC enhancer starr_46669 Neighboring gene WD repeat domain 45 Neighboring gene PRA1 domain family 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MOS2, a protein containing G-patch and KOW motifs, is essential for innate immunity in Arabidopsis thaliana. Zhang Y, et al. Curr Biol, 2005 Nov 8. PMID 16271871
    2. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Brunkow ME, et al. Nat Genet, 2001 Jan. PMID 11138001
    3. A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Means GD, et al. Genomics, 2000 May 1. PMID 10857745
    4. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159038

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    G-patch domain and KOW motifs-containing protein
    Names
    g patch domain and KOW motifs-containing protein
    protein MOS2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173747.3 → NP_776108.2  G-patch domain and KOW motifs-containing protein

      See identical proteins and their annotated locations for NP_776108.2

      Status: VALIDATED

      Source sequence(s)
      AK028433, BC092224, BC120679, BI076639, BY074098, CK333382
      Consensus CDS
      CCDS29969.2
      UniProtKB/Swiss-Prot
      A0JLW7, A2AEU7, Q56A08, Q6P5V0, Q8C1C3
      Related
      ENSMUSP00000076178.6, ENSMUST00000049896.13
      Conserved Domains (3) summary
      cd13152
      Location:244 → 298
      KOW_GPKOW_A; KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat A
      cd13153
      Location:431 → 481
      KOW_GPKOW_B; KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat B
      pfam12656
      Location:154 → 211
      G-patch_2; DExH-box splicing factor binding site

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      7563373..7576500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q56A08.2 GenPept UniProtKB/Swiss-Prot:Q56A08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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