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    cox-6A Cytochrome c oxidase subunit 6A, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 175693, updated on 5-May-2024

    Summary

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    Gene symbol
    cox-6A
    Gene description
    Cytochrome c oxidase subunit 6A, mitochondrial
    Primary source
    WormBase:WBGene00006519
    Locus tag
    CELE_F54D8.2
    See related
    AllianceGenome:WB:WBGene00006519
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable enzyme regulator activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Is expressed in body wall musculature; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate D and cytochrome-c oxidase deficiency disease. Orthologous to several human genes including COX6A2 (cytochrome c oxidase subunit 6A2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (5081726..5082995)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Aldehyde dehydrogenase domain-containing protein Neighboring gene ncRNA Neighboring gene Alpha-carbonic anhydrase domain-containing protein;Putative carbonic anhydrase-like protein 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial modulation of phosphine toxicity and resistance in Caenorhabditis elegans. Zuryn S, et al. Toxicol Sci, 2008 Mar. PMID 17998274
    2. NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis. Gao J, et al. PLoS Genet, 2015 Mar. PMID 25768301, Free PMC Article
    3. The embryonic muscle transcriptome of Caenorhabditis elegans. Fox RM, et al. Genome Biol, 2007. PMID 17848203, Free PMC Article
    4. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Haynes CM, et al. Mol Cell, 2010 Feb 26. PMID 20188671, Free PMC Article
    5. β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans. Walser M, et al. PLoS Genet, 2017 Jan. PMID 28135265, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxidative phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cytochrome c oxidase subunit 6A, mitochondrial
    NP_498082.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5081726..5082995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065681.9 → NP_498082.1  Cytochrome c oxidase subunit 6A, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498082.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20779
      Conserved Domains (1) summary
      cd00925
      Location:38 → 122
      Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20779.1

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