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    ell-1 OCEL domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177206, updated on 23-May-2024

    Summary

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    Gene symbol
    ell-1
    Gene description
    OCEL domain-containing protein
    Primary source
    WormBase:WBGene00021281
    Locus tag
    CELE_Y24D9A.1
    See related
    AllianceGenome:WB:WBGene00021281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in transcription elongation from RNA polymerase II promoter. Located in nucleus. Is expressed in hypodermis; intestine; pharynx; tail; and vulva. Orthologous to several human genes including ELL (elongation factor for RNA polymerase II) and ELL2 (elongation factor for RNA polymerase II 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ell-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (4394410..4415621)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein eL8 Neighboring gene SET domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene Seven TM Receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes. Cai L, et al. J Biol Chem, 2011 Oct 14. PMID 21880729, Free PMC Article
    2. Identification of a genetic interaction between the tumor suppressor EAF2 and the retinoblastoma protein (Rb) signaling pathway in C. elegans and prostate cancer cells. Cai L, et al. Biochem Biophys Res Commun, 2014 May 2. PMID 24727455, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes.
      Title: Regulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription elongation factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    OCEL domain-containing protein
    NP_001299985.1
    • Confirmed by transcript evidence
    NP_001379985.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4394410..4415621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392296.1 → NP_001379985.1  OCEL domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N554
      Conserved Domains (2) summary
      pfam07303
      Location:560 → 669
      Occludin_ELL; Occludin homology domain
      pfam10390
      Location:86 → 359
      ELL; RNA polymerase II elongation factor ELL

    2. NM_001313056.3 → NP_001299985.1  OCEL domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARM3
      Conserved Domains (1) summary
      pfam07303
      Location:180 → 289
      Occludin_ELL; Occludin homology domain

    RNA

    1. NR_132459.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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