5N7I


Conserved Protein Domain Family
Occludin_ELL
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pfam07303: Occludin_ELL (this model, PSSM-Id:369308 is obsolete and has been replaced by 462140)
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Occludin homology domain
This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.
Links
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Statistics
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PSSM-Id: 369308
Aligned: 119 rows
Threshold Bit Score: 79.8722
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5N7I_A         10 YPVIQTDDEREAYKAVFQDQFSEYKELSAEVQAVLRKFDELDAVMSRLPHHSEs--rQEHEAISRIHEEFKKKKNDPTFL 87   human
EER95365     1095 KGPIKDYSQYKDYVQEYNEKYGVYSYLNSQIDKTKSEFLKVQDDLNVAKERDKe---QYYNTVERLRDMYRES--GARHK 1169 sorghum
XP_004236392 1124 KGPIENFAQYEEYVQEYREKYDSYCSINKILESYRNEFIKLGKELDVSKGRDTk---RFSDMLGQLKDSYRKC--GPRHV 1198 tomato
XP_002276282 1149 KGPIKDFSQYKEYVQEYHEKYDSYNSLNKILESYRNEFHKLGKDLEVAKGRDLe---RYYNILEQLKDTYSQC--STRHK 1223 wine grape
NP_566681    1088 KGPISDHLQYKAYMQEYNDKYDSYHSINKILESHRNDFQKLGQDLGFAKGRDVe---RYNKIVEQIKESYCKY--GERHK 1162 thale cress
CDS27045      638 YPPITNARQAASYRETFESVYPQYLKLHEHYRLAWDKVITLKHQIMALNGGQDn--qKMARLAKE-LDDFLNRMRKPERR 714  Hymenolepis m...
CDS40880      620 YPAISSASQAAAYREAFESLYPKYLRLYEHFRVAWDKVINLKERILALAGGPHv--dQMTRLATE-LDEFLNCMRKPERR 696  Echinococcus ...
XP_018651653  542 YPEISTSEQASMYLAEFECTYPTYLRMYHSFSDIWKTVSNLRSQLLEATRTEGfdsaTTTHLANQ-LDKFIRRSRSQKYR 620  Schistosoma m...
XP_024453346 1163 RGPIKDFSQYQEYVQEYRDKYDSYCSLNRILESYRNEFHKLGKDLESAKGRDMd---RYHNILVQLKDSYSQC--GMKHR 1237 black cottonwood
XP_006651113 1066 KGPIKDLPQYKDYVQEYNEKYEVYSYLNSQIEKTRSEFLKIQEDLNSAKERDKd---LYYRILERIRDMYHES--GTRHK 1140 malo sina

5N7I_A         88 EKKERCDYLKNKLSHIKQRIQEYDK 112  human
EER95365     1170 LMKKVFILLHEELQIIKQRIKDFTE 1194 sorghum
XP_004236392 1199 RLKKIFIVLHEELKHLKQMIKDFAV 1223 tomato
XP_002276282 1224 RLKKIFVVLHEELKNLKQRIKDYAL 1248 wine grape
NP_566681    1163 RLKKVFVVLHEELKHLKQRMRDYAS 1187 thale cress
CDS27045      715 EEEIKLLVMSHKLQHLKHQLADYAA 739  Hymenolepis microstoma
CDS40880      697 DDEVRLLVMTFKLQHLKQRLATFAS 721  Echinococcus multilocularis
XP_018651653  621 DDEIQLTLMVHKLRLLKQRLAVSQH 645  Schistosoma mansoni
XP_024453346 1238 RLKKIFIVLHKELEQLKQRIKDFVP 1262 black cottonwood
XP_006651113 1141 LMKKVFGLLHEELQTIKRRIKDFAD 1165 malo sina
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