Apba3 amyloid beta precursor protein binding family A member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apba3provided by MGI
Official Full Name: amyloid beta precursor protein binding family A member 3provided by MGI
Primary source: MGI:MGI:1888527
See related: Ensembl:ENSMUSG00000004931 AllianceGenome:MGI:1888527
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mint3; Mint-3; lin-10; X11gamma
Summary: Predicted to enable amyloid-beta binding activity; enzyme binding activity; and enzyme inhibitor activity. Acts upstream of or within chemical synaptic transmission; in utero embryonic development; and regulation of gene expression. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm; dendritic spine; and plasma membrane. Orthologous to human APBA3 (amyloid beta precursor protein binding family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 37.3), duodenum adult (RPKM 34.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (81102799..81109081)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81266935..81273247)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mint3 depletion-mediated glycolytic and oxidative alterations promote pyroptosis and prevent the spread of Listeria monocytogenes infection in macrophages.
Title: Mint3 depletion-mediated glycolytic and oxidative alterations promote pyroptosis and prevent the spread of Listeria monocytogenes infection in macrophages.
APBA3-deficient mice show reduced metastasis, with no apparent effect on primary tumor growth. APBA3 deficiency in inflammatory monocytes hampers glycolysis-dependent chemotaxis of cells toward metastatic sites.
Title: Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes.
we have identified Mint3 as a physiological positive regulator of TLR3/4 and RIG-I-induced IFN-beta production and have outlined a feedback mechanism for the control of antiviral immune responses.
Title: Mint3 potentiates TLR3/4- and RIG-I-induced IFN-β expression and antiviral immune responses.
Mint3 depletion attenuated metastasis to the lungs in breast cancer model mice.
Title: Mint3 in bone marrow-derived cells promotes lung metastasis in breast cancer model mice.
Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock.
Title: Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock.
X11L2 functions in the nucleus by a mechanism distinct from conventional transactivators
Title: The X11L/X11beta/MINT2 and X11L2/X11gamma/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm.
Binding of Munc18-1 to closed, target-SNARE syntaxin 1 stimulates vesicle docking and regulates the consecutive priming step during exocytosis of secretory or synaptic vesicles.
Title: Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming.
Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV
Title: Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV.
Mints are important regulators of presynaptic neurotransmitter release that are essential for mouse survival.
Title: Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW208791 (e-PCR)
- UniSTS:180067

RH131893 (e-PCR)
- UniSTS:215176

RH128401 (e-PCR)
- UniSTS:211709

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amyloid-beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemical synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: amyloid-beta A4 precursor protein-binding family A member 3

Names: Mint 3; adapter protein X11gamma; amyloid beta (A4) precursor protein-binding, family A, member 3; neuron-specific X11L2 protein; neuronal munc18-1-interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429264.1 → NP_001416193.1 amyloid-beta A4 precursor protein-binding family A member 3 isoform a

Status: VALIDATED

Source sequence(s)

AC155932
NM_001429265.1 → NP_001416194.1 amyloid-beta A4 precursor protein-binding family A member 3 isoform a

Status: VALIDATED

Source sequence(s)

AC155932
NM_001429266.1 → NP_001416195.1 amyloid-beta A4 precursor protein-binding family A member 3 isoform b

Status: VALIDATED

Source sequence(s)

AC155932
NM_001429267.1 → NP_001416196.1 amyloid-beta A4 precursor protein-binding family A member 3 isoform b

Status: VALIDATED

Source sequence(s)

AC155932
NM_018758.3 → NP_061228.1 amyloid-beta A4 precursor protein-binding family A member 3 isoform a

See identical proteins and their annotated locations for NP_061228.1

Status: VALIDATED

Source sequence(s)

AC155932

Consensus CDS

CCDS24050.1

UniProtKB/Swiss-Prot

O88888, Q3TDI1, Q8BR09

UniProtKB/TrEMBL

Q8BNM8

Related

ENSMUSP00000050995.9, ENSMUST00000057798.9

Conserved Domains (2) summary

cd00992
Location:480 → 548

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:209 → 361

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

RNA

NR_190703.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC155932
NR_190704.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC155932
NR_190705.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC155932

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

81102799..81109081

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513905.1 → XP_006513968.1 amyloid-beta A4 precursor protein-binding family A member 3 isoform X1

See identical proteins and their annotated locations for XP_006513968.1

UniProtKB/Swiss-Prot

O88888, Q3TDI1, Q8BR09

UniProtKB/TrEMBL

Q8BNM8

Related

ENSMUSP00000151985.2, ENSMUST00000220297.2

Conserved Domains (2) summary

cd00992
Location:480 → 548

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:209 → 361

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
XM_006513907.5 → XP_006513970.1 amyloid-beta A4 precursor protein-binding family A member 3 isoform X2

UniProtKB/TrEMBL

Q8BNM8

Conserved Domains (2) summary

cd00992
Location:471 → 539

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:209 → 352

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
XM_006513906.5 → XP_006513969.1 amyloid-beta A4 precursor protein-binding family A member 3 isoform X1

UniProtKB/Swiss-Prot

O88888, Q3TDI1, Q8BR09

UniProtKB/TrEMBL

Q8BNM8

Conserved Domains (2) summary

cd00992
Location:480 → 548

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:209 → 361

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
XM_036155901.1 → XP_036011794.1 amyloid-beta A4 precursor protein-binding family A member 3 isoform X1

UniProtKB/Swiss-Prot

O88888, Q3TDI1, Q8BR09

UniProtKB/TrEMBL

Q8BNM8

Conserved Domains (2) summary

cd00992
Location:480 → 548

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:209 → 361

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain