Arhgap23 Rho GTPase activating protein 23 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap23provided by MGI
Official Full Name: Rho GTPase activating protein 23provided by MGI
Primary source: MGI:MGI:3697726
See related: Ensembl:ENSMUSG00000049807 AllianceGenome:MGI:3697726
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A330041B18Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Is expressed in several structures, including aorta; brain; endocrine gland; female reproductive system; and retina. Orthologous to human ARHGAP23 (Rho GTPase activating protein 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 28.9), lung adult (RPKM 24.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 60.97 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (97295183..97393228)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (97404357..97502402)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rho GTPase-activating protein 23

Names: rho-type GTPase-activating protein 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001428751.1 → NP_001415680.1 rho GTPase-activating protein 23 isoform 1

Status: VALIDATED

Source sequence(s)

AL596088

UniProtKB/TrEMBL

B1AQY2
NM_021493.3 → NP_067468.2 rho GTPase-activating protein 23 isoform 2

See identical proteins and their annotated locations for NP_067468.2

Status: VALIDATED

Source sequence(s)

AL596088

Consensus CDS

CCDS36293.1

UniProtKB/Swiss-Prot

Q69ZH9, Q8BNY7, Q9JJD6

UniProtKB/TrEMBL

F8VQ11

Related

ENSMUSP00000103227.2, ENSMUST00000107601.8

Conserved Domains (3) summary

cd04395
Location:692 → 887

RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

cd01253
Location:480 → 600

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

pfam00169
Location:479 → 598

PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

97295183..97393228

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533867.3 → XP_006533930.1 rho GTPase-activating protein 23 isoform X6

UniProtKB/Swiss-Prot

Q69ZH9, Q8BNY7, Q9JJD6

Conserved Domains (4) summary

PHA03247
Location:158 → 560

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:23 → 138

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:885 → 1080

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:673 → 793

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_030246200.1 → XP_030102060.1 rho GTPase-activating protein 23 isoform X1

UniProtKB/Swiss-Prot

Q69ZH9, Q8BNY7, Q9JJD6

Conserved Domains (4) summary

PHA03247
Location:77 → 479

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:4 → 57

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:804 → 999

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:592 → 712

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_036156873.1 → XP_036012766.1 rho GTPase-activating protein 23 isoform X1

UniProtKB/Swiss-Prot

Q69ZH9, Q8BNY7, Q9JJD6

Conserved Domains (4) summary

PHA03247
Location:77 → 479

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:4 → 57

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:804 → 999

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:592 → 712

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_006533865.4 → XP_006533928.1 rho GTPase-activating protein 23 isoform X4

UniProtKB/Swiss-Prot

Q69ZH9, Q8BNY7, Q9JJD6

Conserved Domains (4) summary

PHA03247
Location:176 → 578

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:41 → 156

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:903 → 1098

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:691 → 811

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_006533866.4 → XP_006533929.1 rho GTPase-activating protein 23 isoform X5

Related

ENSMUSP00000112999.2, ENSMUST00000121799.8

Conserved Domains (4) summary

PHA03247
Location:176 → 578

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:41 → 156

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:903 → 1098

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:691 → 811

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_006533869.4 → XP_006533932.2 rho GTPase-activating protein 23 isoform X8

Conserved Domains (4) summary

PHA03247
Location:77 → 479

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:4 → 57

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:804 → 999

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:592 → 712

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_006533868.5 → XP_006533931.2 rho GTPase-activating protein 23 isoform X8

Conserved Domains (4) summary

PHA03247
Location:77 → 479

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:4 → 57

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:804 → 999

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:592 → 712

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_006533861.5 → XP_006533924.2 rho GTPase-activating protein 23 isoform X1

UniProtKB/Swiss-Prot

Q69ZH9, Q8BNY7, Q9JJD6

Conserved Domains (4) summary

PHA03247
Location:77 → 479

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:4 → 57

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:804 → 999

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:592 → 712

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_006533862.5 → XP_006533925.2 rho GTPase-activating protein 23 isoform X2

UniProtKB/Swiss-Prot

Q69ZH9, Q8BNY7, Q9JJD6

Conserved Domains (4) summary

PHA03247
Location:77 → 479

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:4 → 57

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:804 → 999

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:592 → 712

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_006533863.5 → XP_006533926.2 rho GTPase-activating protein 23 isoform X3

UniProtKB/Swiss-Prot

Q69ZH9, Q8BNY7, Q9JJD6

Conserved Domains (4) summary

PHA03247
Location:77 → 479

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:4 → 57

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:721 → 916

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cl17171
Location:496 → 629

PH-like; Pleckstrin homology-like domain
XM_030246201.2 → XP_030102061.1 rho GTPase-activating protein 23 isoform X7

UniProtKB/Swiss-Prot

Q69ZH9, Q8BNY7, Q9JJD6

Conserved Domains (3) summary

PHA03247
Location:20 → 422

PHA03247; large tegument protein UL36; Provisional

cd04395
Location:747 → 942

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:535 → 655

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_006533871.5 → XP_006533934.1 rho GTPase-activating protein 23 isoform X9

UniProtKB/Swiss-Prot

Q69ZH9, Q8BNY7, Q9JJD6

Conserved Domains (3) summary

PHA03307
Location:3 → 281

PHA03307; transcriptional regulator ICP4; Provisional

cd04395
Location:692 → 887

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:480 → 600

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
XM_006533874.4 → XP_006533937.1 rho GTPase-activating protein 23 isoform X10

Conserved Domains (2) summary

cd04395
Location:107 → 302

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cl17171
Location:1 → 15

PH-like; Pleckstrin homology-like domain
XM_036156874.1 → XP_036012767.1 rho GTPase-activating protein 23 isoform X11

Conserved Domains (2) summary

cd04395
Location:107 → 302

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cl17171
Location:1 → 15

PH-like; Pleckstrin homology-like domain