IL17D interleukin 17D [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL17Dprovided by HGNC
Official Full Name: interleukin 17Dprovided by HGNC
Primary source: HGNC:HGNC:5984
See related: Ensembl:ENSG00000172458 MIM:607587; AllianceGenome:HGNC:5984
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IL-17D
Summary: The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 13.7), ovary (RPKM 2.3) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q12.11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (20701513..20723098)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (19894661..19916241)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (21275652..21297237)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin-17D produced by alveolar epithelial type II cells alleviates LPS-induced acute lung injury via the Nrf2 pathway.
Title: Interleukin-17D produced by alveolar epithelial type II cells alleviates LPS-induced acute lung injury via the Nrf2 pathway.
Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway.
Title: Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway.
Nuclear factor erythroid 2-related factor 2 potentiates the generation of inflammatory cytokines by intestinal epithelial cells during hyperoxia by inducing the expression of interleukin 17D.
Title: Nuclear factor erythroid 2-related factor 2 potentiates the generation of inflammatory cytokines by intestinal epithelial cells during hyperoxia by inducing the expression of interleukin 17D.
Nrf2 Induces IL-17D to mediate tumor and virus surveillance.
Title: Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance.
Study of the expression of IL-17 provides theoretical support for the clinical treatment and prognosis prediction of ovarian epithelial tumor.
Title: Expression of inflammatory cytokines in ovarian epithelial cancer and their correlation.
Utilizing gene microarray analysis, authors found the cytokine interleukin 17D (IL-17D) was highly expressed in certain unedited tumors.
Title: Interleukin-17D mediates tumor rejection through recruitment of natural killer cells.
These experiments were designed to investigate the effects of IL-17 upon the phenotype and function of human Natural Killer (NK) cells.
Title: The effects of IL-17 upon human natural killer cells.
IL-27 priming results in enhanced lipopolysaccharide-induced IL-6, tumor necrosis factor (TNF)-alpha, macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta expression in human primary monocytes.
Title: IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes.
Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.
IL-17D stimulates production of cytokines in endothelial cells in vitro and suppresses proliferation of myeloid progenitors in colony formation assays.
Title: Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic determinants of P wave duration and PR segment. EBI GWAS Catalog EBI GWAS CatalogPubMed
GWAS of dental caries patterns in the permanent dentition. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13S502E (e-PCR)
- UniSTS:153178

IL17D_1537 (e-PCR)
- UniSTS:277366

RH101972 (e-PCR)
- UniSTS:23167

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of hemopoiesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine production involved in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-8 production	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-17D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001385221.1 → NP_001372150.1 interleukin-17D isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Isoforms a and b are the same length but differ in their N-termini.

Source sequence(s)

AL161772, AL512652

Conserved Domains (1) summary

pfam06083
Location:96 → 177

IL17; Interleukin-17
NM_001385222.1 → NP_001372151.1 interleukin-17D isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes the longest isoform (b). Isoforms a and b are the same length but differ in their N-termini.

Source sequence(s)

AL161772, AL512652

Conserved Domains (1) summary

pfam06083
Location:96 → 177

IL17; Interleukin-17
NM_001385223.1 → NP_001372152.1 interleukin-17D isoform c precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.

Source sequence(s)

AL161772, AL512652

Consensus CDS

CCDS9292.1

UniProtKB/Swiss-Prot

B1AM69, Q8TAD2

Conserved Domains (1) summary

pfam06083
Location:89 → 170

IL17; Interleukin-17
NM_001385224.1 → NP_001372153.1 interleukin-17D isoform c precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.

Source sequence(s)

AL161772, AL512652

Consensus CDS

CCDS9292.1

UniProtKB/Swiss-Prot

B1AM69, Q8TAD2

Related

ENSP00000508385.1, ENST00000682841.1

Conserved Domains (1) summary

pfam06083
Location:89 → 170

IL17; Interleukin-17
NM_001385225.1 → NP_001372154.1 interleukin-17D isoform d

Status: REVIEWED

Source sequence(s)

AL161772, AL512652

Conserved Domains (1) summary

pfam06083
Location:11 → 86

IL17; Interleukin-17
NM_001386973.1 → NP_001373902.1 interleukin-17D isoform e

Status: REVIEWED

Source sequence(s)

AL512652

Conserved Domains (1) summary

pfam06083
Location:9 → 82

IL17; Interleukin-17
NM_138284.2 → NP_612141.1 interleukin-17D isoform c precursor

See identical proteins and their annotated locations for NP_612141.1

Status: REVIEWED

Description

Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform c.

Source sequence(s)

AL161772, AL512652

Consensus CDS

CCDS9292.1

UniProtKB/Swiss-Prot

B1AM69, Q8TAD2

Related

ENSP00000302924.3, ENST00000304920.3

Conserved Domains (1) summary

pfam06083
Location:89 → 170

IL17; Interleukin-17

RNA

NR_169590.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL161772, AL512652
NR_169591.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL161772, AL512652