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    Rps6ka6 ribosomal protein S6 kinase A6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317203, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Rps6ka6provided by RGD
    Official Full Name
    ribosomal protein S6 kinase A6provided by RGD
    Primary source
    RGD:1560817
    See related
    Ensembl:ENSRNOG00000002592 AllianceGenome:RGD:1560817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560817
    Summary
    Predicted to enable ribosomal protein S6 kinase activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation of ERK1 and ERK2 cascade; and negative regulation of mesoderm development. Predicted to be located in fibrillar center and mitochondrion. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human RPS6KA6 (ribosomal protein S6 kinase A6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 29.0), Kidney (RPKM 23.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rps6ka6 in Genome Data Viewer
    Location:
    Xq31
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (80537723..80638910, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (76353316..76454502, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (82641679..82743771, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene cylicin 1 Neighboring gene tropomyosin 3, pseudogene 3 Neighboring gene transfer RNA arginine (anticodon CCU) 9 Neighboring gene CWC22 spliceosome associated protein homolog, pseudogene 2 Neighboring gene highly divergent homeobox Neighboring gene serine and arginine rich splicing factor 10, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of mouse Rsk4 as an inhibitor of fibroblast growth factor-RAS-extracellular signal-regulated kinase signaling. Myers AP, et al. Mol Cell Biol, 2004 May. PMID 15121846, Free PMC Article
    2. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Berns K, et al. Nature, 2004 Mar 25. PMID 15042092
    3. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M. Nat Rev Mol Cell Biol, 2006 Feb. PMID 16421520
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mesoderm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S6 kinase alpha-6
    Names
    ribosomal protein S6 kinase polypeptide 6
    NP_001178650.1
    XP_008771565.2
    XP_008771566.2
    XP_038955653.1
    XP_038955659.1
    XP_063136084.1
    XP_063136085.1
    XP_063136086.1
    XP_063136087.1
    XP_063136088.1
    XP_063136089.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191721.2 → NP_001178650.1  ribosomal protein S6 kinase alpha-6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6AQN6
      Conserved Domains (4) summary
      smart00220
      Location:190 → 447
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:194 → 508
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:543 → 829
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
      pfam00069
      Location:543 → 800
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      80537723..80638910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280018.1 → XP_063136088.1  ribosomal protein S6 kinase alpha-6 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JXA6

    2. XM_039099725.2 → XP_038955653.1  ribosomal protein S6 kinase alpha-6 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXA6, A0A8I6G3H3
      Conserved Domains (2) summary
      cd05582
      Location:115 → 429
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:464 → 753
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

    3. XM_063280015.1 → XP_063136085.1  ribosomal protein S6 kinase alpha-6 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JXA6

    4. XM_063280019.1 → XP_063136089.1  ribosomal protein S6 kinase alpha-6 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JXA6

    5. XM_063280017.1 → XP_063136087.1  ribosomal protein S6 kinase alpha-6 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JXA6

    6. XM_063280014.1 → XP_063136084.1  ribosomal protein S6 kinase alpha-6 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXA6, A0A8I6G3H3

    7. XM_008773343.3 → XP_008771565.2  ribosomal protein S6 kinase alpha-6 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXA6, A0A8I6G3H3
      Related
      ENSRNOP00000096344.1
      Conserved Domains (2) summary
      cd05582
      Location:115 → 429
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:464 → 753
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

    8. XM_008773344.3 → XP_008771566.2  ribosomal protein S6 kinase alpha-6 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JXA6
      Conserved Domains (2) summary
      cd05582
      Location:115 → 429
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:464 → 748
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

    9. XM_039099731.2 → XP_038955659.1  ribosomal protein S6 kinase alpha-6 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JXA6
      Related
      ENSRNOP00000003512.7
      Conserved Domains (2) summary
      cd05582
      Location:115 → 429
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:464 → 750
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

    10. XM_063280016.1 → XP_063136086.1  ribosomal protein S6 kinase alpha-6 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JXA6
    Nucleotide Protein Strain
    Heading Accession and Version

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