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    Zfp496 zinc finger protein 496 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287361, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Zfp496provided by RGD
    Official Full Name
    zinc finger protein 496provided by RGD
    Primary source
    RGD:1304611
    See related
    Ensembl:ENSRNOG00000003129 AllianceGenome:RGD:1304611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf496; Zkscan17
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein self-association. Predicted to be involved in positive regulation of transcription, DNA-templated and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body. Orthologous to human ZNF496 (zinc finger protein 496). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 81.4), Thymus (RPKM 75.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp496 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (44768463..44787386, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (44268923..44287795, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (45833259..45852130, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ferritin light chain 1 pseudogene Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8-like Neighboring gene ribosomal protein L18, pseudogene 6 Neighboring gene uncharacterized LOC134480800 Neighboring gene uncharacterized LOC134480694 Neighboring gene NLR family, pyrin domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nizp1 zinc finger protein localization is determined by SCAN-domain inclusion regulated through alternative splicing. Kahns S, et al. Biochim Biophys Acta, 2010 Aug. PMID 20538088
    2. Characterization of zinc finger protein 496 that interacts with Jumonji/Jarid2. Mysliwiec MR, et al. FEBS Lett, 2007 Jun 12. PMID 17521633, Free PMC Article
    3. Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif. Nielsen AL, et al. Mol Cell Biol, 2004 Jun. PMID 15169884, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 496
    Names
    zinc finger with KRAB and SCAN domains 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271396.1 → NP_001258325.1  zinc finger protein 496

      Status: VALIDATED

      Source sequence(s)
      FQ223523, JAXUCZ010000010
      UniProtKB/TrEMBL
      F1LVS9
      Related
      ENSRNOP00000055109.3, ENSRNOT00000058308.4
      Conserved Domains (7) summary
      cd07765
      Location:220 → 248
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:314 → 567
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:401 → 421
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:516 → 537
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:455 → 477
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:50 → 126
      SCAN; SCAN domain
      pfam13465
      Location:441 → 464
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      44768463..44787386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246451.4 → XP_006246513.1  zinc finger protein 496 isoform X1

      See identical proteins and their annotated locations for XP_006246513.1

      Conserved Domains (7) summary
      cd07765
      Location:220 → 248
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:332 → 568
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402 → 422
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:517 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:456 → 478
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:50 → 126
      SCAN; SCAN domain
      pfam13465
      Location:442 → 465
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006246450.2 → XP_006246512.1  zinc finger protein 496 isoform X1

      See identical proteins and their annotated locations for XP_006246512.1

      Conserved Domains (7) summary
      cd07765
      Location:220 → 248
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:332 → 568
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402 → 422
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:517 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:456 → 478
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:50 → 126
      SCAN; SCAN domain
      pfam13465
      Location:442 → 465
      zf-H2C2_2; Zinc-finger double domain

    3. XM_039085391.2 → XP_038941319.1  zinc finger protein 496 isoform X3

      Conserved Domains (5) summary
      COG5048
      Location:312 → 548
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:497 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:30 → 104
      SCAN; SCAN domain
      cl02581
      Location:200 → 228
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    4. XM_063268605.1 → XP_063124675.1  zinc finger protein 496 isoform X2

      UniProtKB/TrEMBL
      F1LVS9

    5. XM_006246452.4 → XP_006246514.1  zinc finger protein 496 isoform X3

      Conserved Domains (5) summary
      COG5048
      Location:312 → 548
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:497 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:30 → 104
      SCAN; SCAN domain
      cl02581
      Location:200 → 228
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    6. XM_008767781.4 → XP_008766003.1  zinc finger protein 496 isoform X4

      Conserved Domains (5) summary
      cd07765
      Location:65 → 93
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:177 → 413
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:362 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:301 → 323
      zf-C2H2; Zinc finger, C2H2 type

    7. XM_063268607.1 → XP_063124677.1  zinc finger protein 496 isoform X5

    8. XM_039085392.2 → XP_038941320.1  zinc finger protein 496 isoform X4

      Conserved Domains (5) summary
      cd07765
      Location:65 → 93
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:177 → 413
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:362 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:301 → 323
      zf-C2H2; Zinc finger, C2H2 type

    9. XM_039085393.2 → XP_038941321.1  zinc finger protein 496 isoform X4

      Conserved Domains (5) summary
      cd07765
      Location:65 → 93
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:177 → 413
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:362 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:301 → 323
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein Strain
    Heading Accession and Version

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