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    Adam26a ADAM metallopeptidase domain 26A [ Mus musculus (house mouse) ]

    Gene ID: 13525, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Adam26aprovided by MGI
    Official Full Name
    ADAM metallopeptidase domain 26Aprovided by MGI
    Primary source
    MGI:MGI:105985
    See related
    Ensembl:ENSMUSG00000048516 AllianceGenome:MGI:105985
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dtgn4; Adam26
    Summary
    This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during the late stages of spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. This gene is located adjacent to two other ADAM genes on chromosome 8. [provided by RefSeq, May 2016]
    Expression
    Restricted expression toward testis adult (RPKM 10.9) See more
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    Genomic context

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    See Adam26a in Genome Data Viewer
    Location:
    8 A4; 8 24.02 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (44021310..44029744, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (43568273..43576707, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21328 Neighboring gene STARR-seq mESC enhancer starr_21332 Neighboring gene predicted gene, 53410 Neighboring gene STARR-seq mESC enhancer starr_21334 Neighboring gene a disintegrin and metallopeptidase domain 26B Neighboring gene STARR-seq mESC enhancer starr_21335 Neighboring gene STARR-seq mESC enhancer starr_21336 Neighboring gene a disintegrin and metallopeptidase domain 26B pseudogene Neighboring gene a disintegrin and metallopeptidase domain 34 like Neighboring gene a disintegrin and metallopeptidase domain 34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization. Zhu GZ, et al. Gene, 1999 Jul 8. PMID 10395895
    2. A family of cellular proteins related to snake venom disintegrins. Weskamp G, et al. Proc Natl Acad Sci U S A, 1994 Mar 29. PMID 8146185, Free PMC Article
    3. Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice. Han C, et al. Biol Reprod, 2009 May. PMID 19129510
    4. Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations. Grayson P, et al. BMC Evol Biol, 2013 Sep 30. PMID 24079728, Free PMC Article
    5. Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. West DB, et al. PLoS Genet, 2016 Feb. PMID 26839965, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables integrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm head plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 26A
    Names
    a disintegrin and metallopeptidase domain 26A (testase 3)
    a disintegrin and metalloprotease domain 26
    disintegrin 4
    testase 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010085.3 → NP_034215.2  disintegrin and metalloproteinase domain-containing protein 26A preproprotein

      See identical proteins and their annotated locations for NP_034215.2

      Status: REVIEWED

      Source sequence(s)
      AC131115, AK029756
      Consensus CDS
      CCDS22269.1
      UniProtKB/Swiss-Prot
      G3X9D0, Q9R158
      UniProtKB/TrEMBL
      Q8BMR4
      Related
      ENSMUSP00000058256.3, ENSMUST00000049577.3
      Conserved Domains (5) summary
      smart00608
      Location:477 → 613
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:195 → 383
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:401 → 474
      Disintegrin; Disintegrin
      pfam01421
      Location:195 → 385
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:39 → 146
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      44021310..44029744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R158.2 GenPept UniProtKB/Swiss-Prot:Q9R158

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