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    Capn15 calpain 15 [ Mus musculus (house mouse) ]

    Gene ID: 50817, updated on 12-May-2024

    Summary

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    Official Symbol
    Capn15provided by MGI
    Official Full Name
    calpain 15provided by MGI
    Primary source
    MGI:MGI:1355075
    See related
    Ensembl:ENSMUSG00000037326 AllianceGenome:MGI:1355075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Solh
    Summary
    Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in brain; genitourinary system; and retina ganglion cell layer. Orthologous to human CAPN15 (calpain 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 32.7), ovary adult (RPKM 26.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 13.04 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26177338..26204753, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25958364..25985874, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class Q Neighboring gene RIKEN cDNA gene D630044L22 gene Neighboring gene NHL repeat containing 4 Neighboring gene proline rich 35 Neighboring gene RIKEN cDNA 1700022N22 gene Neighboring gene RAB11 family interacting protein 3 (class II) Neighboring gene STARR-positive B cell enhancer ABC_E1937 Neighboring gene STARR-seq mESC enhancer starr_42116 Neighboring gene membrane-associated ring finger (C3HC4) 5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MRI of Capn15 Knockout Mice and Analysis of Capn 15 Distribution Reveal Possible Roles in Brain Development and Plasticity. Zha C, et al. Neuroscience, 2021 Jun 15. PMID 33951504
    2. Solh, the mouse homologue of the Drosophila melanogaster small optic lobes gene: organization, chromosomal mapping, and localization of gene product to the olfactory bulb. Kamei M, et al. Genomics, 2000 Feb 15. PMID 10708520
    3. Biallelic variants in the small optic lobe calpain CAPN15 are associated with congenital eye anomalies, deafness and other neurodevelopmental deficits. Zha C, et al. Hum Mol Genet, 2020 Nov 4. PMID 32885237, Free PMC Article
    4. The LMO2 oncogene regulates DNA replication in hematopoietic cells. Sincennes MC, et al. Proc Natl Acad Sci U S A, 2016 Feb 2. PMID 26764384, Free PMC Article
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel association of Dandy-Walker malformation with CAPN15 variants expands the phenotype of oculogastrointestinal neurodevelopmental syndrome.
      Title: Novel association of Dandy-Walker malformation with CAPN15 variants expands the phenotype of oculogastrointestinal neurodevelopmental syndrome.
    2. Behavioral characterization of Capn15 conditional knockout mice.
      Title: Behavioral characterization of Capn15 conditional knockout mice.
    3. Biallelic variants in the small optic lobe calpain CAPN15 are associated with congenital eye anomalies, deafness and other neurodevelopmental deficits.
      Title: Biallelic variants in the small optic lobe calpain CAPN15 are associated with congenital eye anomalies, deafness and other neurodevelopmental deficits.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-dependent cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calpain-15
    Names
    small optic lobes homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347334.2 → NP_001334263.1  calpain-15 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC159277
      Consensus CDS
      CCDS84286.1
      UniProtKB/Swiss-Prot
      Q6PEE9, Q9JLG8
      UniProtKB/TrEMBL
      A0A1D5RLS3
      Related
      ENSMUSP00000148486.2, ENSMUST00000212520.2

    2. NM_001413962.1 → NP_001400891.1  calpain-15 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC159277

    3. NM_001413963.1 → NP_001400892.1  calpain-15 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC159277
      Related
      ENSMUSP00000039528.9, ENSMUST00000041641.9

    4. NM_001413964.1 → NP_001400893.1  calpain-15 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC159277

    5. NM_001413965.1 → NP_001400894.1  calpain-15 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC159277

    6. NM_015830.3 → NP_056645.2  calpain-15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159277
      Consensus CDS
      CCDS28540.1

    RNA

    1. NR_151779.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159277
      Related
      ENSMUST00000212789.2

    2. NR_182225.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159277

    3. NR_182226.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159277

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26177338..26204753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524605.4 → XP_006524668.1  calpain-15 isoform X1

      UniProtKB/Swiss-Prot
      Q6PEE9, Q9JLG8
      Conserved Domains (4) summary
      smart00547
      Location:490 → 514
      ZnF_RBZ; Zinc finger domain
      cd00044
      Location:552 → 847
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      sd00025
      Location:457 → 472
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00029
      Location:420 → 439
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    2. XM_006524609.5 → XP_006524672.1  calpain-15 isoform X4

      UniProtKB/Swiss-Prot
      Q6PEE9, Q9JLG8
      Related
      ENSMUSP00000148718.2, ENSMUST00000212149.2
      Conserved Domains (4) summary
      smart00547
      Location:424 → 448
      ZnF_RBZ; Zinc finger domain
      cd00044
      Location:486 → 801
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      sd00025
      Location:391 → 406
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00029
      Location:354 → 373
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RNA

    1. XR_003952148.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLG8.1 GenPept UniProtKB/Swiss-Prot:Q9JLG8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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