fxr2 FMR1 autosomal homolog 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fxr2provided by ZNC
Official Full Name: FMR1 autosomal homolog 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-943
See related: Ensembl:ENSDARG00000016260 AllianceGenome:ZFIN:ZDB-GENE-040426-943
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56215; zgc:77472; id:ibd5046
Summary: Predicted to enable mRNA 3'-UTR binding activity; protein homodimerization activity; and translation regulator activity. Predicted to be involved in several processes, including positive regulation of response to DNA damage stimulus; regulation of filopodium assembly; and regulation of gene expression. Predicted to act upstream of or within regulation of translation. Predicted to be located in cytoplasm. Predicted to be part of polysome. Predicted to be active in several cellular components, including dendrite; growth cone; and postsynaptic density. Is expressed in mesoderm; musculature system; and somite. Orthologous to human FXR2 (FMR1 autosomal homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (22718732..22761090)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (22447575..22489933)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fi51f10.x1 (e-PCR)
- UniSTS:197678

fd27f03.y1 (e-PCR)
- UniSTS:195391

fc43f08.y1 (e-PCR)
- UniSTS:193864

fb26a09.y1 (e-PCR)
- UniSTS:190373

fc58d06 (e-PCR)
- UniSTS:189429

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables translation regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of long-term neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA stability	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation at presynapse, modulating synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fragile X mental retardation syndrome-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200211.2 → NP_956505.2 fragile X mental retardation syndrome-related protein 2

See identical proteins and their annotated locations for NP_956505.2

Status: PROVISIONAL

Source sequence(s)

BC066684

UniProtKB/TrEMBL

Q6NY99

Related

ENSDARP00000004667.7, ENSDART00000027718.9

Conserved Domains (5) summary

smart00322
Location:219 → 280

KH; K homology RNA-binding domain

cd00105
Location:286 → 368

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam05641
Location:62 → 120

Agenet; Agenet domain

pfam12235
Location:370 → 471

FXMRP1_C_core; Fragile X-related 1 protein core C terminal

pfam16096
Location:504 → 577

FXR_C1; Fragile X-related 1 protein C-terminal region 2