Conserved Protein Domain Family
FXMRP1_C_core
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pfam12235: FXMRP1_C_core (this model, PSSM-Id:289039 is obsolete and has been replaced by 463501)
Fragile X-related 1 protein core C terminal
This domain family is found in eukaryotes, and is typically between 126 and 160 amino acids in length. The family is found in association with pfam05641, pfam00013. This family is the core C terminal region of the fragile X related 1 proteins FXR1P, FXR2 and FMR1. These different proteins have different regions at their very C-terminus. The Glutamine-arginine rich region facilitates protein interactions. This family contains two blocks of RGG repeats that bind to G-quartet sequences in a wide variety of mRNAs.
Links
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Statistics
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PSSM-Id: 289039
Aligned: 26 rows
Threshold Bit Score: 78.7042
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002070709 374 HLSHLK----------------EVEKLRQEKLEIDQQLRAIQESSMGStQNFpvsrrSER----GYSSDIESVRSmrggg 433 Drosophila will...
CAF91309     387 HISYLNvsrvrlgwrlglggpeEVEQLRLERLQIDEQLRQLTQGHRPAeRER-----EERgereGYHTD-GSANAasssl 460 spotted green p...
NP_958458    354 HIAYLN----------------EVEQLRLERLQIDEQLRQIGMGFRSVpNRP-----ADKe--kGFGPD----ESssgsi 406 zebrafish
XP_007256837 354 HISYLN----------------EVEQLRLERLQIDEQLRQIGLGYRPVpGRP-----AEKd--kGYNTD---ESAsnapl 407 Mexican tetra
XP_012401920 269 HIAYLK----------------EVEQLRMERLQIDEQLRQIGMGFRPSsTRG-----PEKe--kGYATD----EStvssv 321 Tasmanian devil
ETN63329     359 HLMHLK----------------EVEQLRQEKLDIDQQLRAIQGTTMNTlQNFamnrrSDR----PYHNDg---------d 409 Anopheles darlingi
XP_006613419 372 HLAHLK----------------EVEQLRQEKLEIDQQLRNMHGSTTGPmPNFppt-------rrGMITGPEEGGGgrggr 428 giant honeybee
XP_011142587 413 HLAHLK----------------EVEQLRQEKLEIDQQLRSMHGSTTGPmPNFppt-------rrGMVAGPEEGVSgrggr 469 Jerdon's jumpin...
EFX73353     358 HLAHLK----------------EVEQLRMEKLEIDQQLRSIHNSNLTSaPTFppprrIDR----GYSAEpd--------n 409 common water flea
XP_003381310 274 HMNHLK----------------EMESLRQEAQELNRQLR----GRMTPpHNNysnnqSRSe--rAYHSDIESNPPvrgrg 331 Trichinella spi...

XP_002070709 434 GAQR----GRRGRGGgggGGSGGGGgg----gnGLNQRYQNNRRDDDDYNS--------------------RGDHQRDQQ 485 Drosophila will...
CAF91309     461 HVSRt--yNGRGRGR---RG--HHAg------yGTNLDPANASETDSERRDelsdwslag--edqdgerepRPQR--DAR 523 spotted green p...
NP_958458    407 HTQRs----yRGRGR---RGPAHTSa------yGTNSEHSYTSETDSERKAelsdwsla----adesernpRPQR--DSR 467 zebrafish
XP_007256837 408 HSSRs--yAGRGRGR---RGMHYTS--------GTNSEHSYASETDSERKDelsdwsla----geepdrgvRPQR--DSR 468 Mexican tetra
XP_012401920 322 QGSRs--ySGRGRGR---RGPNYTSg------yGTNSELSNPSETESERKDelsdwsla-----geddresRHQR--DSR 383 Tasmanian devil
ETN63329     410 GGSRpnrgLMRNRGGrggRGSNP----------RYNSRRGVEHDEDFMHNDreqrgn---------nymevRNNRIVQRG 470 Anopheles darlingi
XP_006613419 429 GG------QSRGRGG----------------------------------------------------------------- 437 giant honeybee
XP_011142587 470 GG------QSRGRGS---RGRAPTRhn-----------agLRRDTMDSSEDrvrdlpprgghqggagnsgyMSGRQGRPT 529 Jerdon's jumpin...
EFX73353     410 GGNRdrgnMTRGRGRgggRGAPVSSvvmdnssgGSRLHSALSSKEGTPAEStaknithagsshsaaasgppHSRDQRNRY 489 common water flea
XP_003381310 332 G-------YGRPRGRy-mRGAPPNSggdsdmmyQARERRRQVDEESNPAPEhpedrdsassqeagtnmgirRNRRRregr 403 Trichinella spi...

XP_002070709 486 RGysDRGSAGD 496 Drosophila willistoni
CAF91309     524 RR--PGPGRGR 532 spotted green pufferfish
NP_958458    468 RR--DMRGRGR 476 zebrafish
XP_007256837 469 RR--PLVGRGR 477 Mexican tetra
XP_012401920 384 RR--PG-GRGR 391 Tasmanian devil
ETN63329     471 FSekRFGGGGG 481 Anopheles darlingi
XP_006613419     -----------     giant honeybee
XP_011142587 530 TQrrDRRDERr 540 Jerdon's jumping ant
EFX73353     490 dkpsgsrkqiv 500 common water flea
XP_003381310 404 vhrwtggrgsg 414 Trichinella spiralis
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