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    Ahsa2 AHA1, activator of heat shock protein ATPase 2 [ Mus musculus (house mouse) ]

    Gene ID: 268390, updated on 9-May-2024

    Summary

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    Official Symbol
    Ahsa2provided by MGI
    Official Full Name
    AHA1, activator of heat shock protein ATPase 2provided by MGI
    Primary source
    MGI:MGI:1916133
    See related
    Ensembl:ENSMUSG00000020288 AllianceGenome:MGI:1916133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ATPase activator activity. Predicted to be involved in positive regulation of ATPase activity and protein folding. Predicted to be active in cytosol. Orthologous to human AHSA2P (activator of HSP90 ATPase homolog 2, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 24.7), CNS E14 (RPKM 23.2) and 26 other tissues See more
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    Genomic context

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    See Ahsa2 in Genome Data Viewer
    Location:
    11 A3.2; 11 14.32 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23437882..23448045, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23487882..23498045, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene exportin 1 Neighboring gene ubiquitin specific peptidase 34 Neighboring gene STARR-seq mESC enhancer starr_28911 Neighboring gene RIKEN cDNA 1700030C12 gene Neighboring gene STARR-positive B cell enhancer ABC_E9818 Neighboring gene predicted gene, 22753 Neighboring gene STARR-seq mESC enhancer starr_28912 Neighboring gene RIKEN cDNA 1700093K21 gene Neighboring gene STARR-seq mESC enhancer starr_28914 Neighboring gene STARR-seq mESC enhancer starr_28915 Neighboring gene STARR-seq mESC enhancer starr_28916 Neighboring gene STARR-seq mESC enhancer starr_28917 Neighboring gene selenoprotein K, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus. Li X, et al. Antioxid Redox Signal, 2014 Oct 20. PMID 24483844, Free PMC Article
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36626, 1110064P04Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of ATP-dependent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    activator of 90 kDa heat shock protein ATPase homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290654.1 → NP_001277583.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_001277583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR and uses a downstream AUG, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK034661, AK137116, CJ147821
      Consensus CDS
      CCDS70149.1
      UniProtKB/TrEMBL
      F6S1R2
      Related
      ENSMUSP00000105166.2, ENSMUST00000109539.8
      Conserved Domains (2) summary
      cd08892
      Location:154 → 277
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
      smart01000
      Location:1 → 110
      Aha1_N; Activator of Hsp90 ATPase, N-terminal

    2. NM_001290655.1 → NP_001277584.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK034661, AK137116, AL672049, CJ147821
      UniProtKB/Swiss-Prot
      Q8N9S3
      Conserved Domains (2) summary
      smart01000
      Location:29 → 158
      Aha1_N; Activator of Hsp90 ATPase, N-terminal
      cl14643
      Location:202 → 274
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    3. NM_172391.4 → NP_765979.3  activator of 90 kDa heat shock protein ATPase homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_765979.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK034661, AK137116, CJ147821
      Consensus CDS
      CCDS24476.1
      UniProtKB/Swiss-Prot
      Q0P626, Q6P3F2, Q7TMW7, Q8CBI4, Q8N9S3
      UniProtKB/TrEMBL
      F6S1R2
      Related
      ENSMUSP00000020529.7, ENSMUST00000020529.13
      Conserved Domains (3) summary
      cd08892
      Location:202 → 325
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
      smart01000
      Location:29 → 158
      Aha1_N; Activator of Hsp90 ATPase, N-terminal
      COG5580
      Location:20 → 321
      COG5580; Activator of HSP90 ATPase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      23437882..23448045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246029.2 → XP_030101889.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X3

      Conserved Domains (1) summary
      cd08892
      Location:40 → 163
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins

    2. XM_030246028.2 → XP_030101888.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X1

      Conserved Domains (2) summary
      smart01000
      Location:1 → 110
      Aha1_N; Activator of Hsp90 ATPase, N-terminal
      cl14643
      Location:154 → 226
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    3. XM_011243722.3 → XP_011242024.1  activator of 90 kDa heat shock protein ATPase homolog 2 isoform X2

      See identical proteins and their annotated locations for XP_011242024.1

      Conserved Domains (1) summary
      smart01000
      Location:29 → 157
      Aha1_N; Activator of Hsp90 ATPase, N-terminal

    RNA

    1. XR_003949450.2 RNA Sequence

    2. XR_003949448.1 RNA Sequence

    3. XR_003949449.2 RNA Sequence

    4. XR_004936969.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N9S3.2 GenPept UniProtKB/Swiss-Prot:Q8N9S3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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