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    Cacul1 CDK2 associated, cullin domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 78832, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cacul1provided by MGI
    Official Full Name
    CDK2 associated, cullin domain 1provided by MGI
    Primary source
    MGI:MGI:1926082
    See related
    Ensembl:ENSMUSG00000033417 AllianceGenome:MGI:1926082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700078E11Rik; 2810417M16Rik; 9830127L17Rik; D130033C15Rik
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in G1/S transition of mitotic cell cycle; positive regulation of cell population proliferation; and positive regulation of protein kinase activity. Orthologous to human CACUL1 (CDK2 associated cullin domain 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 11.0), placenta adult (RPKM 7.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cacul1 in Genome Data Viewer
    Location:
    19 D3; 19 56.52 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (60513143..60569420, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (60524696..60581023, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34300 Neighboring gene prolactin releasing hormone receptor Neighboring gene predicted gene, 41884 Neighboring gene STARR-seq mESC enhancer starr_46598 Neighboring gene STARR-positive B cell enhancer ABC_E3256 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60684594-60684894 Neighboring gene STARR-seq mESC enhancer starr_46599 Neighboring gene predicted gene, 46652 Neighboring gene predicted gene, 34459 Neighboring gene predicted gene, 34406

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2. Kigoshi Y, et al. Sci Rep, 2015 Aug 4. PMID 26238671, Free PMC Article
    2. CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis. Jang MJ, et al. Cell Death Dis, 2017 Dec 11. PMID 29233982, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARgamma and inhibit adipogenesis.
      Title: CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis.
    2. Cacul1 regulates the antioxidant response by stabilizing Nrf2.
      Title: CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CDK2-associated and cullin domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172096.2 → NP_001165567.1  CDK2-associated and cullin domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC108409
      Consensus CDS
      CCDS50484.1
      UniProtKB/TrEMBL
      E9PV69, Q921D1
      Related
      ENSMUSP00000127014.2, ENSMUST00000166712.9
      Conserved Domains (1) summary
      pfam00888
      Location:146 → 278
      Cullin; Cullin family

    2. NM_001172097.2 → NP_001165568.1  CDK2-associated and cullin domain-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001165568.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons in the coding region that result in a frameshift, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC108409
      Consensus CDS
      CCDS50483.1
      UniProtKB/Swiss-Prot
      Q8R0X2
      Related
      ENSMUSP00000107086.4, ENSMUST00000111460.5
      Conserved Domains (1) summary
      pfam00888
      Location:146 → 276
      Cullin; Cullin family

    3. NM_030197.3 → NP_084473.1  CDK2-associated and cullin domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_084473.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC108409
      Consensus CDS
      CCDS38034.1
      UniProtKB/Swiss-Prot
      Q3TE79, Q8R0X2, Q9CY95
      UniProtKB/TrEMBL
      Q921D1
      Related
      ENSMUSP00000080480.8, ENSMUST00000081790.15
      Conserved Domains (1) summary
      pfam00888
      Location:146 → 264
      Cullin; Cullin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      60513143..60569420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527468.5 → XP_006527531.1  CDK2-associated and cullin domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006527531.1

      UniProtKB/TrEMBL
      Q3TAW5
      Conserved Domains (1) summary
      pfam00888
      Location:14 → 138
      Cullin; Cullin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0X2.1 GenPept UniProtKB/Swiss-Prot:Q8R0X2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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