4A0L_E 31 QKLKEAVEAIqn--sTSIKYN-------LE-ELY------QAVENLCs--YKISANLYKQLRQICEDHIKaqihQFRE-- 90 human A0BYN1 19 KYLDDACYLIae--hQTKQLS-------FA-ELY------QHAYKLIl--NKFGDFAYSQLQISIHNVVDklisPLNI-- 78 Paramecium tetr... Q236H3 56 DVIEQAIQMIye--kKTHTLS-------YQ-ELY------HHAYILAf--YGHGDQAYSRLKSLLEKYSLkmlnTLGY-- 115 Tetrahymena the... Q24DT3 30 qnyfeknwleieqflKSIYESedincycFQ-HFY------DMISSICd--NEFDELLYKKLEEFYRLKFNvilnDIAL-- 98 Tetrahymena the... XP_003958060 33 EIIDDAFEKIya--nNTEEIS-------FE-KTY------HVVYNLVi--YKRSDDLYNHLKELFTSKLTelkdSQFS-- 92 Kazachstania af... XP_001306671 15 KRVEEGLDSIih--rQPCKHD-------FN-SLY------SSTDKIIn--NDNQAKLFDLLNNKINEEIAkwekQLKE-- 74 Trichomonas vag... XP_001313897 16 EEISKSITSIlt--hKHSSLS-------LS-YLY------NCMNNLVn--NSCTNKLRDTLQNHLDKQFSkqynSLSK-- 75 Trichomonas vag... CCK70086 27 LVLKEGLDKIyt--dCIEDVS-------YQ-DLY------KLVYSLVi--NENGELLYKHLKEYLVERLTssmvetlmpe 88 Kazachstania na... XP_001014520 80 DRVRRNLKTGea--iKISNEE-------YC-KLQseirntD-QFNLIg----------NWHKEQILNYVNsik------- 131 Tetrahymena the... A0CFE8 16 NNLRDHIEKVlkgekKVYNTK-------ETmTFY------TEIFNYIvqgEQQGQKMYDLFKGYNEDFLKesekIARQ-- 80 Paramecium tetr...
4A0L_E 91 -------DSLDSVlfL------------KKIDRCWQNHCRQMIMIRSIFLFLDR---------------TYvlqnsmlpS 136 human A0BYN1 79 -------SNDDQl--L------------YDFVQAFEEVQHFSKLLAGILLYMEK---------------SYilqk-slkT 121 Paramecium tetr... Q236H3 116 -------YDSEEQi-L------------VKMVAVWQDYKQMINILKGIFLYLDN---------------NYvttk-nlqP 159 Tetrahymena the... Q24DT3 99 -------QPEDf---I------------NKIEKEWIKINRCLIILSEIFKQFEG---------------SY--------- 132 Tetrahymena the... XP_003958060 93 -------DLNQDWeiL------------QKVAEFWKIQRENFNLVADLMIYLDR---------------VYcksn-rlpE 137 Kazachstania af... XP_001306671 75 -------VTSNSl--L------------SLFSTLYDNFKIYSDIIPKIYSSYDSksspenksrmiirriYF--------- 124 Trichomonas vag... XP_001313897 76 -------TALVNPl-V------------IKFSKHCSYFASFLKILPKLYSRYDEsla---------ensEY--------R 118 Trichomonas vag... CCK70086 89 ippnqeegleqtwtfL------------IKFDQFFEREAKRFKLVADVMIYFDK---------------VYcnaq-ripE 140 Kazachstania na... XP_001014520 132 -------------idLdsktnvpeeeyiKLISKHYYDFQILVMWIQKFLMSHET---------------FYfkaqlq--- 180 Tetrahymena the... A0CFE8 81 -------SLKSDKnfI------------EEILYQHEIYEIHTRILQSYFTYLDRsfvev-----lnntsQY--------P 128 Paramecium tetr...
4A0L_E 137 IWDM-----GLELFRAHIIsdqk---------vqnkTIDGILLLIERERngea---------idrSLL-----------R 182 human A0BYN1 122 IKTI-----CNESFKIKCFekdqn--------lankLLNCFLSQIRNDRnsqf---------iehFKLkkal----qilI 175 Paramecium tetr... Q236H3 160 VLVL-----GYEVFQQILFiqkse--------iyskVLEIILTMIDKQRlgen---------iegQLIqkii----qmsV 213 Tetrahymena the... Q24DT3 133 LYKT-----KTPSFDNFILkilsdqfnqefnslldaIITSLLDTFRNIRdqnp---------ynhEQLkhlm----gmiI 194 Tetrahymena the... XP_003958060 138 IVDL-----ALHVFRDIILhpl-----------kedVNKAISVTINQVRqtpsy------gnskfEVLkeli----smlE 191 Kazachstania af... XP_001306671 125 ---------KLVISDRSIIs---------------sVTKALLKQIDYFRdtpt--------dtnySIPkniv----dsfY 168 Trichomonas vag... XP_001313897 119 TEKI-----LFTKFKEKVLnqtk---------vvdlIIKSMIDVIEDARtnri--------vsgtANLrqii----elfY 172 Trichomonas vag... CCK70086 141 VFDL-----GLNAFRDTVVfpl-----------kdnLNESIIKVINNARdegqikrsfvleavqiSVLkslf----hmmE 200 Kazachstania na... XP_001014520 181 ---ttcfkkSFEFFRDEYFlgl-----------kdrLIEKVFKFVQKARqnvd---------vpkEELkrvv----qiyD 233 Tetrahymena the... A0CFE8 129 NLKQqakkqFYEQFYNKLFf---------------sIKEEFKAKLKLDR----------------ILLdkesqlllqrvY 177 Paramecium tetr...
4A0L_E 183 --SLlsml--------------------sdlqIYQ----------DSFEQRFLEETNRLYAAEGQKLMQer--evPEYLH 228 human A0BYN1 176 --DLnqeqqiknkey------nytidyrinddFYK----------HFLERKLIQDSRSYFKEESQSNLNkm--tiEEYIL 235 Paramecium tetr... Q236H3 214 --DLgmkaniqkcnqys---rqiqyeyipeltIYE----------KYFEKGYLDCSEKYFSEESQRLILql--spKDYII 276 Tetrahymena the... Q24DT3 195 --KIg---------------------------SYE----------NQFKSHFFEQSNKYYLDLQQKHRAnf--dlRVYLQ 233 Tetrahymena the... XP_003958060 192 --TIsdk----------------------ddtFFE----------TYFEDYFINETKNYYDNTISAInl----paPDLFA 233 Kazachstania af... XP_001306671 169 --------------------------------QFNpdcdennkilATFKIDFTGGVYAYFNQ-FFEKRNec--diAKYTS 213 Trichomonas vag... XP_001313897 173 --------------------------------EYKnsncd-rsifENFMASLKESTKKKYEN---EYNSse--nfVEFLK 214 Trichomonas vag... CCK70086 201 tiSAeknd--------------------dpnhFYT----------GIFEPLLIERSSEYYRN----NVDwtdytaLQTFE 246 Kazachstania na... XP_001014520 234 dqDFgndirieedrqshklrvisdsssnkqsnNYV----------DLFEKPYLVEIEKHFQK-QASLWTdk--ttPEYVQ 300 Tetrahymena the... A0CFE8 178 --KI----------------------------IYGmktfqdignnQLIQKEIKEDSKTYYQQQYSNFQQ------QSFLD 221 Paramecium tetr...
4A0L_E 229 HVNKRL---EEEADRLI--------TyLdqt-----tqKS-LIATVEKQLLG-EHL---------------TAILQK--G 273 human A0BYN1 236 FVEKRY---LDEVDRVQ--------HyIpki-----shQK-VLDCFIKIYIT-SNA------------------------ 273 Paramecium tetr... Q236H3 277 AVERRF---LEEKKRVH--------SyFyqt-----skNK-IQSLFFQKYIN-DFA---------------KAIVDN--Q 321 Tetrahymena the... Q24DT3 234 EIEHRL---QQETGLIE--------AyLska-----tgKI-LIDLIQKHLIA-ENL---------------ETIFSNgfD 280 Tetrahymena the... XP_003958060 234 KIKDLI---ASEYSLDL--------NfLnpd-----tcTK-IKTSIEEFLIS-EKF---------------DVIFVP--L 278 Kazachstania af... XP_001306671 214 DSFTHL---TLEEN-------------Iis----------tIFRKVEADLMFkESVcalfdygdffdidksINVAPL--- 264 Trichomonas vag... XP_001313897 215 RIKELL---DFEENl-----------lLkaifkdeedvNE-ILMIAHESAIF-KNTetfanqkdfqvppiySALQDK--- 275 Trichomonas vag... CCK70086 247 KMGAMI---KFEKAFME--------GlInpd-----ssHK-LIDILTNTFVS-GKL---------------KDILGEliN 293 Kazachstania na... XP_001014520 301 EALIAL---NKEEQLCQ--------Dyyp------rsmNP-INQTINGIIIK-DQT---------------QYLLEHst- 345 Tetrahymena the... A0CFE8 222 QIKSLVqfkQEELGRIRlifgceqsE-L----------QKeLIDLFNNYIIN-SYA---------------SDLNSD--N 272 Paramecium tetr...
4A0L_E 274 ---LN---NLLdenr--------------iqdLSLLYQLFSRV----RGgv-qvLLQQWIEYIK---------------- 312 human A0BYN1 274 --------QHIsqglydfi------enektaiIIIIFQLFVKSeefdL------FVKTFSQIII---------------- 317 Paramecium tetr... Q236H3 322 engLF---NWLdnde--------------vviIKKSHTLFQNTkesyTI-----FLNIFYKYVA---------------- 363 Tetrahymena the... Q24DT3 281 --------DLLnqrd--------------yqnLQRLFHNMRNIdkldF------LKKNWNQYIR---------------- 316 Tetrahymena the... XP_003958060 279 ---IE---TTLkscn--------------kqlLFEVYSLINET----SYrs--rLLEIMDTIVF---------------- 316 Kazachstania af... XP_001306671 265 ---LEkdeTDLld------------------rLNKLTRLYMNGrvepDInrvepLIDLLCNYIKnrmlsfrpqfedgpak 323 Trichomonas vag... XP_001313897 276 --------NLLrwlirdsylrfhqknhimcefIPKICEFMTKDik--------sFEPKFSDHMKln-------------- 325 Trichomonas vag... CCK70086 294 --------EVMtskd--------------rtlLQRLSSISED-----EEyr-rdLVEGVKDYIS---------------- 329 Kazachstania na... XP_001014520 346 --gIE---NMLkngk--------------dneMKDLYKLLCRVkeslAQ-----LGQKVRTYYQ---------------- 385 Tetrahymena the... A0CFE8 273 ndtLK---NIIiqdy--------------yeqFGQLVKFFDHFksntHI-----FVRKFQEIII---------------- 314 Paramecium tetr...
4A0L_E 313 --------AFG----STIV-----IN------------------------------------------------------ 321 human A0BYN1 318 --------DDL----QILNqna---------------------------------------------------------- 327 Paramecium tetr... Q236H3 364 --------HQT----SALAar----------------------------------------------------------- 372 Tetrahymena the... Q24DT3 317 --------RKG----EEIVn------------------------------------------------------------ 324 Tetrahymena the... XP_003958060 317 --------NTI----RGIKieessKKr----------------------------------------------------- 331 Kazachstania af... XP_001306671 324 senkeegaKEGgdeeKAAPakktvAKktvakkiikkkvvakkedneekeddeekeneekpttaepkmrivkkatpkagta 403 Trichomonas vag... XP_001313897 -------------------------------------------------------------------------------- Trichomonas vag... CCK70086 330 --------RDF----YSIKldev--------------------------------------------------------- 340 Kazachstania na... XP_001014520 386 ---------------SCISqkckdAKekisafkpd--------------------------------------------- 405 Tetrahymena the... A0CFE8 315 --------QQG----QEIIveqknRIsqtki------------------------------------------------- 333 Paramecium tetr...
4A0L_E 322 ----------------PEKDKTMVQELLDFKDKVDHIIdicfl---------------knekFI----------NA---- 356 human A0BYN1 328 --------------ntLQGFIKLYEKIFSLYDKIAQYGnneh-----------------qykFH----------KA---- 362 Paramecium tetr... Q236H3 373 ---------------qSTPVKEYIEDIILFRLKIINIMqea------------------ffsLL----------KTddql 409 Tetrahymena the... Q24DT3 325 ----------------EENQDDITQHLLDFFHDLDIIIqkcfe---------------ntnlLK----------QA---- 359 Tetrahymena the... XP_003958060 332 ----------------VQVASEWVSQVIDFYLKYQDLIdfvqiedne-------nvdnddaaNEsdlpsrlpssHF---- 384 Kazachstania af... XP_001306671 404 saaeksskskigkdekITAMKDLIFTALKLYSNFNKIFqdss----------------dkkkMS----------NA---- 453 Trichomonas vag... XP_001313897 326 --------------dkITQIHEIIKKVLSQTEPFEFVFcsqehmrkksddpnfdmekearekFE----------KA---- 377 Trichomonas vag... CCK70086 341 ------------trkkAIAAAKWVSDLVEKFEQYSSFLkgaafaesips---ntaneghsssIA----------SV---- 391 Kazachstania na... XP_001014520 406 -------ktknirdftKETAIEWVKGLIEFKIFVDNQIstlfs---------------ndleLQ----------KA---- 449 Tetrahymena the... A0CFE8 334 ------------kqekEDQKSKFLEQLISLQQSYKKLI------------------------YD----------HAennq 367 Paramecium tetr...
4A0L_E 357 -----MKEAFETFI-NkrpnkPAELi-----aKYVDSKLR---A-G--NKEatDEELEKMLDKI-MIIFRFIY-GKDVFE 417 human A0BYN1 363 -----IKNAFEQVI-Nkdnfi------mmelnIYFDFLMK---Ket-----lrDEEKKLQIDKG-FLIFKLVQ-SKDEFE 420 Paramecium tetr... Q236H3 410 tiqrqTQKSFEDSL-Nds-nfPTEQl-----nCYIDEAFQkdfK----NKS--EQQIEEVLNSV-FEIFCLIR-NKDYFA 474 Tetrahymena the... Q24DT3 360 -----KNYALEHVL-SikvntIAELt-----sKHIDTKLKkqnKtm-----qdHDQIEKDVDDA-LELFRYLP-AKDIFE 421 Tetrahymena the... XP_003958060 385 -----LDTIFSRYI-NtnknqAIQFi-----cFYLDSYLR---M-T--QNKedLEKAKNNLQDC-TKLFKLLR-EKDAFE 445 Kazachstania af... XP_001306671 454 -----VEQAWN----------AKEFrphynlvQFIHY------SvVnnLENi-PDEYKSKFPQIcKLFFDFTT-DKAVFV 510 Trichomonas vag... XP_001313897 378 -----ITAGWNIPAfN-----IVENf-----vQYIDFHIKnekKrL-------SKTENENFERTcARFFRYTE-DKVGFC 434 Trichomonas vag... CCK70086 392 -----LGDATSNFF-AddpmqSAQFv-----sLYFDVQLKa------------SKPSKAELGNV-VMLLKFLS-EKDEFV 446 Kazachstania na... XP_001014520 450 -----RDNAFQISLrEfk--eSPHFl-----sQYCDDLMKqq---------ltDHESNDRQIEV-NAIFDYMNtSRDEFL 507 Tetrahymena the... A0CFE8 368 fllanLRVAFEMITaN-----AEQH-------FIMESLLQklhTfT--LKRi-DIGEEKQLKEV-MQLLECFQ-AKDLLL 430 Paramecium tetr...
4A0L_E 418 AFYKKDLAKRLLVGKsasVDAE---KSMLSKLKH--ECGA--AFTSKLEGMFKDMELSKDIMI-QFKQymqnq----nvp 485 human A0BYN1 421 QIYRKHLCVRLLDQTyssLEVE---KDLLKKLRL--ECGS--VLTHKMETMFSDLERSSEDSQ-KFRQklsqn-----qr 487 Paramecium tetr... Q236H3 475 SIYMKSLAKRILYNKsldENNE---KQIISKFKL--ECGT--VYTKKMETMFLDMQQSLEYYN-EFKQlfiknlntksay 546 Tetrahymena the... Q24DT3 422 AFYNKRLARRLLMNLaysYELE---RKVLDRLRS--ECGD--QYTMKADEILKDVNESKQLNK-DFNDyls--------s 485 Tetrahymena the... XP_003958060 446 NTYTQLLSKRLIQQRs-aLHME---RFMVKQIKD--NMGS--FFTSKMEGMLRDMSTSIVLSK-SFyknfv------ndk 510 Kazachstania af... XP_001306671 511 PLFMNYQIQRIIKNReseQDTRaleFEIVKQLKSigASSNteDFGKHLEEIYNQVRISIDTTK-NFKAtips-------d 582 Trichomonas vag... XP_001313897 435 TTYEQALLQRLIKFLtk-fDAEe--RMMIETISK--EKQP--EFMKGYKDLKACIDNSAQIDD-DFKK------------ 494 Trichomonas vag... CCK70086 447 NVYKQQLSRRLLHQRtt-iDME---RYMINRIKD--EMGS--FFTLKLESMLRDVTTSSELLK-SLPEhe---------- 507 Kazachstania na... XP_001014520 508 LHYQQALCRRLIGFTsksMAAE---KQIVTKFKN--SVGAl-PTLNRLQNMLTDVETNE-----QYNK------------ 564 Tetrahymena the... A0CFE8 431 RNYQNKLAQRILTLFdyhSDFD---KQIIDQFRK--TYGP--EHTKQLESMIKDYEQQKNEEKiTISD------------ 491 Paramecium tetr...
4A0L_E 486 gnIE------LTVNILTMGYWPT----YVPM-E------------------VHLPPEMVKLQEI-FKTFYLGkHSGRKLQ 535 human A0BYN1 488 dsID------LDILVLTSEQWPI----TDSQp-------------------IIIHTELLLWQQQ-FTQYYQSkNSKRKLS 537 Paramecium tetr... Q236H3 547 ksLD------FDIKVLTCGNWPY----KLNQfSq-----------------VKIPNQLEPYISE-FEKHYKSkFKGRKLK 598 Tetrahymena the... Q24DT3 486 qgLDynkkniFSCIVVSSSAWPM----KNQQlP-------------------ILFEPFDKFQKE-FKKFYELkHKGVCIN 541 Tetrahymena the... XP_003958060 511 ekIE------FVPQVLTMTSWPFeninELID-En----------------dVILPPRLEELKQN-FEVTYSKkYGERVLK 566 Kazachstania af... XP_001306671 583 sqVD------FIATVLNHNIVEK----FATDnA------------------FKIMPFLQDLHNR-FVGFYQQnHQNSDLK 633 Trichomonas vag... XP_001313897 495 -----------QI-MNTKIEWPD----GMREvQfspivfnknhyklyiieqTKIPEFLSPVHDR-FIQFYQEkNKSMTLM 557 Trichomonas vag... CCK70086 508 kqFE------FIPQVLTMTAWPF----QNlndf---------------dadLILPRELQKVKEN-LEVAYNKkYNQRVLN 561 Kazachstania na... XP_001014520 565 ---EkvqndiLKIYVLNSVAWPL----KRNElEk-----------------IIFPSSFAGIIDQ-FTKQYNQtYKQRKIF 619 Tetrahymena the... A0CFE8 492 --IE------IQAKILQKEYWPE----IRPQlNld---------------nILILNQLKAAYREkFNSQQEK-NQLIDIS 543 Paramecium tetr...
4A0L_E 536 WQSTLGHCVLKAEF-Keg------kkELQVSLFQTLVLL-MF-NegE---EFSLEEIKQATGIEDGELRRTLQSLac--g 601 human A0BYN1 538 FNYGLGSVSLKATFdQns------kkDFVCSVFQATILM-HF-Nkq---rVYKVDELIKLTNSDKEIMQYELENL----- 601 Paramecium tetr... Q236H3 599 WIYSVGKSIVKG-YySfnn----skkEFQVSNVQMVILL-LF-Nnk---iKYTQQELTALLQMPYEEYKLHLLPL----- 663 Tetrahymena the... Q24DT3 542 WQHETSTCDIQGNYnKek-------yIFQVQLIQGLILL-CF-Nlk---nKLSYTEIHNLVQIDEEELKKNLVSLyamkd 609 Tetrahymena the... XP_003958060 567 WAHTLGLVEIGFQFdKty-------hELVMSTHAAAIFL-MF-EdsD---EVTLDMLHEKTGIAEQELKRHLLSMvla-p 633 Kazachstania af... XP_001306671 634 IIPDISQLQFTFRVpKnkksanlkvyTINTDAWGGSILMaIY-E--AketGLKKADINAITAVKEDLVDAYLKMM----- 705 Trichomonas vag... XP_001313897 558 LLADTSTVQSKWRIpKnsksnkpetyVLTTDILTSKILSyLHkNqt---eKVSVQDIIMYTQEEKPLVKKCIAKL----- 629 Trichomonas vag... CCK70086 562 WAHKLGLIEISYRFeKss-------hDLAMSFYAGLIFL-AF-EeqD---ELTTEKLQQLTNLPEQELVKQLVTLava-p 628 Kazachstania na... XP_001014520 620 WLFNEGSAEINF-TsAnkktf-agkyILRTTSYQMLILM-KM-Nek---aSITIQDLMDQTGINKDSFDNNLKQL----- 687 Tetrahymena the... A0CFE8 544 WQDQLSMVELMFRTnQe--------yKVIIGVVGGAILL-QF-N--HqnnPQTSEQLAQSIGVNNQYFLNQIKLLe---- 607 Paramecium tetr...
4A0L_E 602 kAR-V---LAKNpkgk---------diedGDKF------ICNDD 626 human A0BYN1 602 ----LqfkLLIqn--------------eeENSL------QLNQK 621 Paramecium tetraurelia Q236H3 664 ----VqlkILKse---------------nNIDF------EYNDQ 682 Tetrahymena thermophila SB210 Q24DT3 610 tQK-L---LNKsgeak---------rvdeTDVF------EVNEA 634 Tetrahymena thermophila SB210 XP_003958060 634 rSK-I---LRKVpntr---------tispIDRF------YINYN 658 Kazachstania africana CBS 2517 XP_001306671 706 ----YhmkLIAmkdkgasn-------------kmediewVLNKN 732 Trichomonas vaginalis G3 XP_001313897 630 ----LglqICVrektvkttekqqqqqlsdTDLI------MMNKe 663 Trichomonas vaginalis G3 CCK70086 629 rYR-I---LLKEpntk---------tirmTDTF------RVNER 653 Kazachstania naganishii CBS 8797 XP_001014520 688 ----IklkILSca---------------eEDKYtesstvQVNAQ 712 Tetrahymena thermophila SB210 A0CFE8 608 -SKkL---LTRD-----------------GQAY------KFNEE 624 Paramecium tetraurelia
Jiyao W et al.(2023). "The conserved domain database in 2023.",