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    Pla2g4f phospholipase A2, group IVF [ Mus musculus (house mouse) ]

    Gene ID: 271844, updated on 12-May-2024

    Summary

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    Official Symbol
    Pla2g4fprovided by MGI
    Official Full Name
    phospholipase A2, group IVFprovided by MGI
    Primary source
    MGI:MGI:2685493
    See related
    Ensembl:ENSMUSG00000046971 AllianceGenome:MGI:2685493
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm647; Pla2zeta; 4732472I07Rik
    Summary
    Enables calcium-dependent phospholipase A2 activity and lysophospholipase activity. Acts upstream of or within several processes, including arachidonic acid secretion; cellular response to antibiotic; and prostaglandin biosynthetic process. Located in cytosol; ruffle membrane; and vesicle. Orthologous to human PLA2G4F (phospholipase A2 group IVF). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach adult (RPKM 8.2), placenta adult (RPKM 7.1) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pla2g4f in Genome Data Viewer
    Location:
    2 E5; 2 60.31 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120130433..120144646, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120299952..120314165, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group IVE Neighboring gene predicted gene, 52575 Neighboring gene STARR-seq mESC enhancer starr_05506 Neighboring gene predicted gene, 52560 Neighboring gene phospholipase A2, group IVD Neighboring gene VPS39 HOPS complex subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120178706-120178815 Neighboring gene transmembrane protein 87A Neighboring gene STARR-positive B cell enhancer ABC_E10133 Neighboring gene glucosidase, alpha; neutral C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. Yun B, et al. J Biol Chem, 2014 Jan 17. PMID 24297180, Free PMC Article
    2. Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts. Ghosh M, et al. J Biol Chem, 2007 Apr 20. PMID 17293613, Free PMC Article
    3. Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. Ohto T, et al. J Biol Chem, 2005 Jul 1. PMID 15866882
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. murine cytosolic phospholipases A2 delta, epsilon, and zeta form a gene cluster with cPLA(2)beta
      Title: Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophospholipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within arachidonic acid secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to antibiotic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycerophospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within prostaglandin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytosolic phospholipase A2 zeta
    Names
    cPLA2-zeta
    NP_001019316.1
    NP_001350002.1
    NP_001350003.1
    NP_001350004.1
    XP_006499715.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024145.3 → NP_001019316.1  cytosolic phospholipase A2 zeta isoform 1

      See identical proteins and their annotated locations for NP_001019316.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL844608
      Consensus CDS
      CCDS16618.1
      UniProtKB/Swiss-Prot
      A2AQJ2, Q50L41, Q80VQ8, Q80VV9
      UniProtKB/TrEMBL
      B7ZNT9
      Related
      ENSMUSP00000062607.8, ENSMUST00000054651.8
      Conserved Domains (3) summary
      cd04036
      Location:46 → 162
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      smart00022
      Location:307 → 796
      PLAc; Cytoplasmic phospholipase A2, catalytic subunit
      cl11396
      Location:300 → 848
      Patatin_and_cPLA2; Patatins and Phospholipases

    2. NM_001363073.1 → NP_001350002.1  cytosolic phospholipase A2 zeta isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AL844608
      UniProtKB/TrEMBL
      B2RWZ7
      Conserved Domains (2) summary
      cd04036
      Location:46 → 162
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      cl11396
      Location:300 → 847
      Patatin_and_cPLA2; Patatins and Phospholipases

    3. NM_001363074.1 → NP_001350003.1  cytosolic phospholipase A2 zeta isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AL844608
      UniProtKB/TrEMBL
      B7ZNT9
      Conserved Domains (2) summary
      cd04036
      Location:45 → 161
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      cl11396
      Location:299 → 847
      Patatin_and_cPLA2; Patatins and Phospholipases

    4. NM_001363075.1 → NP_001350004.1  cytosolic phospholipase A2 zeta isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses two alternate in-frame splice junctions compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is 2 aa shorter compared to isoform 1.
      Source sequence(s)
      AL844608
      UniProtKB/TrEMBL
      B7ZNT9
      Conserved Domains (2) summary
      cd04036
      Location:45 → 161
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      cl11396
      Location:299 → 846
      Patatin_and_cPLA2; Patatins and Phospholipases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      120130433..120144646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499652.3 → XP_006499715.1  cytosolic phospholipase A2 zeta isoform X1

      Related
      ENSMUST00000142183.2
      Conserved Domains (2) summary
      pfam18695
      Location:2 → 103
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
      cl11396
      Location:102 → 650
      Patatin_and_cPLA2; Patatins and Phospholipases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q50L41.3 GenPept UniProtKB/Swiss-Prot:Q50L41

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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