1CJY


Conserved Protein Domain Family
PLAc

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smart00022: PLAc 
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Cytoplasmic phospholipase A2, catalytic subunit
Cytosolic phospholipases A2 hydrolyse arachidonyl phospholipids. Family includes phospholipases B isoforms.
Statistics
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PSSM-Id: 214474
Aligned: 12 rows
Threshold Bit Score: 478.46
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1CJY_A    117 KKEVPFIFNQVTEMVLEMSLEvCSCPD-LRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEGLHSA----------- 184 human
Q11121     15 FAQGTLAWSPSNSYTPANVSCdEDINL-IRQASGPSDNETEWLKKRDVYTREALRSFLDRATSNFSDSSlvsql---fsn 90  Torulaspora delbru...
EGA56856   20 FLLAANAWSPTDSYVPGTVSCpDDINL-VREATSISQNESAWLEKRNKVTSVALKDFLTRATANFSDSSevlsklfndgn 98  Saccharomyces cere...
NP_013719  17 SLAADSSSTTGDGYAPSIIPCpSDDTSlVRNASGLSTAETDWLKKRDAYTKEALHSFLSRATSNFSDTSllstl--fssn 94  Saccharomyces cere...
P39457      5 AGVQRALPNAPDGYVPTSVSCpASRPT-VRSAAKLSTNETSWLEVRRGKTLSALKDFFGHVKVGDYDVGayldk--hsgn 81  Penicillium chryso...
NP_593194  19 LAISLSKRDSVGSYAPYNVTCpSDYML-RPASDGISSGEQSFIDKRIPKINTQMRSFISNTGLDVDVNSvi--------n 89  Schizosaccharomyce...
NP_593196  36 RAKKHSTKQEGPSYAPYYVDCpSDNIVeSLSSNEIPSAESEYLSTRSTITNTAMKDFLRNANLPGLNADtl--------s 107 Schizosaccharomyce...
NP_013721  16 LTENVNAWSPNNSYVPANVTCdDDINL-VREASGLSDNETEWLKKRDAYTKEALHSFLNRATSNFSDTSllstl--fgsn 92  Saccharomyces cere...
NP_990754 117 KKEVQLTFNNVTEMTLELSLEvCSSTD-LRFSMALCDEEKKFRQQRKDNIMQSMKSFLGEENSKNLTTS----------- 184 chicken
AAC21591  117 KKEVPFIFNQVTEMILEMSLEvSSCPD-LRFSMALCDQEKTFRQQRKENIKENMKKLLGPKKSEGLYST----------- 184 Norway rat
NP_571370 113 HVTLSIGKTTKVFLDLLLEVCaSTD---LRFSMTLCDQEKLFMQTRRDRVMLSIKKLLKMENPRFLPSSp---------- 179 zebrafish
NP_014386  60 flkslteakfsskfykrvlkdppkigiaisgggyrsmlvgtgfisqmndyglfeysdyiaglsggswilmdlvvqnfevk 139 Saccharomyces cere...
1CJY_A    185 -RDVPVVAILGSGGGFRAMVGFSGVMKALY----E----------SGILDCATYVAGLSGSTWYMSTLYSHPDFPEK--- 246 human
Q11121     91 aSDIPRIAVACSGGGYRAMLSGAGMLAAMD----NrtdganehglGGLLQSTTYLAGLSGGNWLVGTLAWNNWTSVQdiv 166 Torulaspora delbru...
EGA56856   99 sENLPKIAVAVSGGGYRSMLTGAGVLAAMD----NrtegayehglGGLLQSTTYLSGASGGNWLVGTLALNNWTSVQdil 174 Saccharomyces cere...
NP_013719  95 sSNVPKIGIACSGGGYRAMLGGAGMIAAMD----NrtdganehglGGLLQSSTYLSGLSGGNWLTGTLAWNNWTSVQeiv 170 Saccharomyces cere...
P39457     82 sSSLPNIGIAVSGGGWRALMNGAGAVKAFDsrtdNatat---ghlGGLLQSATYISGLSGGSWLLGSIYINNFTTVDk-- 156 Penicillium chryso...
NP_593194  90 dSDGPRLGLAFSGGGLRAMVHGGGVLNAFD----Srngn--gsslAGILQSAMYIAGLSGGSWLVGSVAVNNFANITy-- 161 Schizosaccharomyce...
NP_593196 108 gSEGPSIGIALSGGGLRAMILGSGALSAMD----Arhdn--htvlTGLLQASDYLVGTDGSAWTVGGIALNNFSTINd-- 179 Schizosaccharomyce...
NP_013721  93 sSNMPKIAVACSGGGYRAMLSGAGMLAAMD----NrtdganehglGGLLQGATYLAGLSGGNWLTSTLAWNNWTSVQaiv 168 Saccharomyces cere...
NP_990754 185 -RDVPVIAVLGSGGGFRAMVGFAGVMKALY----E----------SGVLDCATYIAGLSGSTWYMSTLYSHPDFPEK--- 246 chicken
AAC21591  185 -RDVPVVAILGSGGGFRAMVGFSGVMKALY----E----------SGILDCATYVAGLSGSTWYMSTLYSHPDFPEK--- 246 Norway rat
NP_571370 180 -REVPTIAILGSGGGFRAMVGFSGVMKALY----E----------SGVFDCATYVAGLSGSTWYMSMLYSHPEFPAK--- 241 zebrafish
NP_014386 140 sllqewdleedlllgipefdiseeeivtnakkeyndndlkmkkrqggslitsssnfyeqieeimnsieeipedymitkrn 219 Saccharomyces cere...
1CJY_A    247 -GPEEINEELMKNVSHN-------PLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGML----IGETLIH-N----RMN 309 human
Q11121    167 nNMTEDDSIWDISNSIInp---ggFMIVTTIKRWDHISDAVEGKQDAGFNVSLTDIWGRA----LSYNFFP-SlyrgGVA 238 Torulaspora delbru...
EGA56856  175 nNMQNDDSIWDLSDSIVtp---ggINIFKTAKRWDHISNAVESKQNADYNTSLADIWGRA----LAYNFFP-SlnrgGIG 246 Saccharomyces cere...
NP_013719 171 dHMSESDSIWNITKSIVnp---ggSNLTYTIERWESIVQEVQAKSDAGFNISLSDLWARA----LSYNFFP-SlpdaGSA 242 Saccharomyces cere...
P39457    157 lQTHEAGSVWQFGNSIIegpdaggIQLLDSAGYYKDLADAVDGKKKAGFDTTLTDIWGRA----LSYQMFNaSn--gGLS 230 Penicillium chryso...
NP_593194 162 ----LRDNVWNLEHSVFap---hgDNVVENLAYYDDLDDEIDQKKDAGFDTSLTDLWGRA----LSRKLVD-Atq-gGPN 228 Schizosaccharomyce...
NP_593196 180 -----FSKLWAFNHPLMyp----kSAIVFNAHFYSSIMNEVAEKANAGFNISLSDYWGRV----ISRTLGD-Tty-gFPN 244 Schizosaccharomyce...
NP_013721 169 dNTTESNSIWDISHSILtp---dgINIFKTGSRWDDISDDVQDKKDAGFNISLADVWGRA----LAYNFWP-SlhrgGVG 240 Saccharomyces cere...
NP_990754 247 -GPKEINQELMNSVSHN-------PLLLLTPQKVKRYIEALWNKKSSGQPVTFTDIFGML----IGETLIH-N----RMD 309 chicken
AAC21591  247 -GPEEINEELMKNVSHN-------PLLLLTPQKVKRYVESLWKKKSSGLPVTFTDIFGML----IGETLIQ-N----RIV 309 Norway rat
NP_571370 242 -GPGDINKELMNRVSNNp------LKLLLP-QNINRYVKALWKKKSAGQPVTFTDIFGML----IGETLIPg-----RMN 304 zebrafish
NP_014386 220 lnplarlkkiffpnntftgtdakietfkkvlDFYKSLHLKIKPKKMEGFQISFTDYWGKAivqrLKKNFDD-Dp---NHS 295 Saccharomyces cere...
1CJY_A    310 TTLSSLKE---KVNTAQCPLPLFTCLHVKPDVSELMFADW-VEFSPYEIGM--AKYGTFMAPDLFGSKFFMGTVVKKYEE 383 human
Q11121    239 YTWSTLRDv-eVFQNGEMPFPISVADGRYPGTQIIDLNATvFEFNPFEMGSwdPTLNAFTDVKYLGTKVSNGEPVNKGQC 317 Torulaspora delbru...
EGA56856  247 LTWSSIRDf-pVFQNAEMPFPISVADGRYPGTKVINLNATvFEFNPFEMGSwdPSLNSFANVKYLGTNVSNGVPLERGKC 325 Saccharomyces cere...
NP_013719 243 LTWSSLRDv-dVFKNGEMPLPITVADGRYPGTTVINLNATlFEFTPFEMGSwdPSLNAFTDVKYLGTNVTNGKPVNKDQC 321 Saccharomyces cere...
P39457    231 YTWSSIADt-pEFQDGDYPMPFVVADGRNPGELVIGSNSTvYEFNPWEFGTfdPTIFGFVPLEYLGSKFEGGSLPSNESC 309 Penicillium chryso...
NP_593194 229 ITFSSIRNq-tWFQNADYPYPIIISDSRLEEEKAIPANTSiFEFTPYEFGTwdNGIKAFLPMEYVGTHLKNGVPPD-HKC 306 Schizosaccharomyce...
NP_593196 245 VSLSSITSq-eWYRNANFPYPIITFATQNYGEDISNVNTTfFEASPNVFGTfdHGINSFIPTEYLGTTLNNGASSN-GSC 322 Schizosaccharomyce...
NP_013721 241 YTWSTLREa-dVFKNGEMPFPITVADGRYPGTTVINLNATlFEFNPFEMGSwdPTLNAFTDVKYLGTNVTNGKPVNKGQC 319 Saccharomyces cere...
NP_990754 310 TTLSDMKE---KVSEAQCALPLFTCLHVKPDVSELMFADW-VEFSPYEIGM--AKYGTFMSPDLFGSKFFMGTVVKKYSE 383 chicken
AAC21591  310 PTLSSLKE---KVSAARCPLPLFTCLHVKPDVSELMFADW-VEFSPYEIGM--AKYGTFMTPDLFGSKFFMGTVVKKYEE 383 Norway rat
NP_571370 305 IKLSSLKG---KINEGQSPLPLFTCLHVKPDVSELMFADW-VEFSPYEIGM--AKYGTFMSPGLFGSKFFMGSVVKQYEE 378 zebrafish
NP_014386 296 FSFSKLVNsskKFKECSVPIPIFVANCK----NGLLSNVI-FEFTPFEFGSweNILRLFVKLPYLGSKIVSG---KAEKC 367 Saccharomyces cere...
1CJY_A    384 NPLHFLMGVWGSAFSILFNRVLGvsg-----------sqSRGSTMEEELENITTKHIVSNDSSDSDDESHEPKGTENEDA 452 human
Q11121    318 VAGYDNTGFIMGTSSSLFNQFLL----------------QINSTSLPSFIKNLVTGFLDDLSEDEDDIAIYAPNPFKDTS 381 Torulaspora delbru...
EGA56856  326 TAGFDNAGFIMGTSSTLFNQFLL----------------RINSTHLPSFITRLARHFLKDLSQDFNDIAVYSPNPFKDTK 389 Saccharomyces cere...
NP_013719 322 VSGYDNAGFVIATSASLFNEFSLe---------------ASTST-YYKMINSFANKYVNNLSQDDDDIAIYAANPFKDTE 385 Saccharomyces cere...
P39457    310 IRGFDSAGFVIGTSSSLFNQFLL----------------QINTTSLPSFIKDVFNGILFDLDKSQNDIASYDPNPF---- 369 Penicillium chryso...
NP_593194 307 IRNYDNAGFVMGTSATLFNTFLLe---------------WSQEVTSNSTLYDIIHKVFEKLSEDQNDIAPY-PNPYQNFT 370 Schizosaccharomyce...
NP_593196 323 VINYDNFGFMMGASSTYFNKIMR------------------NFNDSSTKNGRIIQQYLKGNFSENGQQIISIPNPFQGVE 384 Schizosaccharomyce...
NP_013721 320 IAGFDNTGFITATSSTLFNQFLL----------------RLNSTDLPSFIANLATDFLEDLSDNSDDIAIYAPNPFKEAN 383 Saccharomyces cere...
NP_990754 384 NPLHFLMGVWGSAFSILFNRVLGvsn-----------sqNKGPTMEEELENIRLKHLVSNDSSDSEDESQHPKGTENSEA 452 chicken
AAC21591  384 NPLHFLMGVWGSAFSILFNRVLGvsg-----------lqNKGSTMEEELENITAKHIVSNDSSDSDDEAQGPKGTENEDA 452 Norway rat
NP_571370 379 NPLHFLMGVWGSAFSILFNRVLGvk------------etTSSSTMEEELEQIKPEHIVGDDSADNEEETQRG-GTESADA 445 zebrafish
NP_014386 368 INNFDDLGFITATSSSIFNNVLIfiwnlasqssreamkaLNMVMGIFGLGKEEIFSISKDSSRLETDYAVYQPNPF---- 443 Saccharomyces cere...
1CJY_A    453 gsdyqsdnqasWIHRMIMALVSDSALFNTREgragkvhnfmlGLNLNTSYPLSPLsdFATQDSFDDDELDAAVADPDEFE 532 human
Q11121    382 -----------YIQDNFSKSISESDYLYLVD-----------GGEDNQNIPLVPL--VQDERNVDVIFALDNSADTDYYW 437 Torulaspora delbru...
EGA56856  390 -----------FLDSDYTTSIVDSDSLFLVD-----------GGEDDENVPVLPL--IQKERDVDIIFAVDNSADMRLAW 445 Saccharomyces cere...
NP_013719 386 -----------FVDRNYTSSIVDADDLFLVD-----------GGEDGQNLPLVPL--IKKERDLDVVFALDISDNTDESW 441 Saccharomyces cere...
P39457    370 -----------YKYNEHSSPYAAQKLLDVVD-----------GGEDGQNVPLHPL--IQPERHVDVIFAVDSSADTDYFW 425 Penicillium chryso...
NP_593194 371 -----------TTNTTVKNPFERFDTIDLVD-----------GGEDDENIPIWPL--LHPQRFVDVIFAVDATYDDSNGW 426 Schizosaccharomyce...
NP_593196 385 -----------SANSDAANNLGSSSSLNLVD-----------TFLTGEKIPLWPL--LQKGRDVDVIVAVDNGDDSEWLW 440 Schizosaccharomyce...
NP_013721 384 -----------FLQKNATSSIIESEYLFLVD-----------GGEDNQNIPLVPL--LQKERELDVIFALDNSADTDDYW 439 Saccharomyces cere...
NP_990754 453 neeyqnssqesWVQRMLMALVGDSALFNTREgragkvhnfmlGLNLNSCYPLSPLadLLTQESVEEDELDAAVADPDEFE 532 chicken
AAC21591  453 ereyqndnqasWVHRMLMALVSDSALFNTREgragkvhnfmlGLNLNTSYPLSPLrdFSPQDSFDDDELDAAVADPDEFE 532 Norway rat
NP_571370 446 ederqrhaqasWVQRMLTSIMGDTTLFTTREgragkvhnfmlGLNLNSTLPFSPFsgITHQTSLEEE--VDAVTDPDEFE 523 zebrafish
NP_014386 444 -----------YLYPEKDNVLTNKNHLYLVD-----------GGEDGENIPLRTL--VIPERELDVIFVLDSSSDID-NY 498 Saccharomyces cere...
1CJY_A    533 RIYEPLdVKSKKIHVVDS--GLt--fNLPYPLILRPQRGVDLIISFDFSARPSDSS-------------PPFKELLLAEK 595 human
Q11121    438 PDGASL-VSTYERQFSSQ--GL----NMSFPYVPDKRTFVNLGLADKPSFFGCDAQnltd-----lnyiPPLVVYIPNAR 505 Torulaspora delbru...
EGA56856  446 PDGSSL-VHTYERQFVKQ--GQ----GMSFPYVPDTNTFVNLGLNKKPTFFGCDANnltd-----lqyiPPLVVYLPNAE 513 Saccharomyces cere...
NP_013719 442 PSGVCM-TNTYERQYSKQ--GK----GMAFPYVPDVNTFLNLGLTNKPTFFGCDAKnltd-----leyiPPLVVYIPNTK 509 Saccharomyces cere...
P39457    426 PNGTSL-VATYERSLNSS--GIa--nGTAFPAVPDQNTFINLGLSTRPSFFGCDSSnqt--------gpSPLVVYIPNAP 492 Penicillium chryso...
NP_593194 427 PDGSSI-VTTYERIITYN--ANksvdVRGFPYIPDEDTIISLGLNTHPTFFGCDGRnttagnhtvdnntPPLLVYFPNYP 503 Schizosaccharomyce...
NP_593196 441 PNGNSL-VQTYERVVAAQaaGNt--nVKGFPYVPSQQSFVSLHFNDRPVFFGCDGRnttagnhtvtrdtPPLVIYLPNVP 517 Schizosaccharomyce...
NP_013721 440 PDGASL-VNTYQRQFGSQ--GL----NLSFPYVPDVNTFVNLGLNKKPTFFGCDARnltd-----leyiPPLIVYIPNSR 507 Saccharomyces cere...
NP_990754 533 RIYEPLdVKSKKIHIVDS--GLt--fNLPYPLILRPQRGVDLIISFDFSARPSDSS-------------PPFKEILLAEK 595 chicken
AAC21591  533 RIYEPLdVKSKKIHVVDS--GLt--fNLPYPLILRPQRGVDLIISFDFSARPSDTS-------------PPFKELLLAEK 595 Norway rat
NP_571370 524 RIYEPLdVKSKKIHVVDS--GLt--fNLPYPLILRCQRGVDLIISFDFSARPSDSS-------------PPFKELLLAEK 586 zebrafish
NP_014386 499 PNGSKL-KRIFEKLDEEN--VHy---QFPNNVKTFTHPIVIGCNATKRTGHDSfl-------------pIIIYHANANHG 559 Saccharomyces cere...
1CJY_A    596 WAKMNKLPFPKIDPYVFDREGLK-ECYVFKPKNPDMEKDCptIIHFVLANINFRKYKAP--GVPRETEEEKEIADFD 669 human
Q11121    506 HSYNSNTSTFKLSYTDDERLKMIkNGFEAATRGNLTDDSS--FMGCVACAVMRRKQQSL--NATLPEECSTCFTNYC 578 Torulaspora delbrueckii
EGA56856  514 YSFNSNQSAFKLSYSESQRRSMIqNGFEIATRNNFTDDPE--FMGCVGCAIIRRKQQAL--NITLPPECETCFKNYC 586 Saccharomyces cerevis...
NP_013719 510 HSFNGNQSTLKMNYNVTERLGMIrNGFEAATMGNFTDDSN--FLGCIGCAIIRRKQESL--NATLPPECTKCFADYC 582 Saccharomyces cerevis...
P39457    493 YSYHSNISTFQLSTDDAERDNIIlNGYEVATMANSTLDDN--WTACVACAILSRSFERT--GTTLPDICSQCFDRYC 565 Penicillium chrysogenum
NP_593194 504 WVYYSNISTFTMSMNDTLSSGILeNAALSATQNNS---DS--FAVCLACAMIQRSLERK--NMSTPSQCSSCFEQYC 573 Schizosaccharomyces p...
NP_593196 518 YNYFTNISTDRTYYTEDMIQQLLtNGLISSTVDNDTY-----FGQCFACAVVKRTLERN--NITASPECQQCYYNYC 587 Schizosaccharomyces p...
NP_013721 508 HSFNGNQSTFKMSYSDSERLGMIkNGFEAATMGNFTDDSD--FLGCVGCAIIRRKQQNL--NATLPSECSQCFTNYC 580 Saccharomyces cerevis...
NP_990754 596 WAKMNKLPFPKIDPNVFDREGLK-ECYVFKPKDTSSEKDCptIIHFVLANINFRKYKAP--GLPRESKEEKdfadfd 669 chicken
AAC21591  596 WAKMNKLPFPKIDPYVFDREGLK-ECYVFKPKNPDVEKDCttIIHFVLANINFRKYKAP--GVLRETKEEKEIADFD 669 Norway rat
NP_571370 587 WARMNKLPFPKIDSKVFDREGLK-ECYVFKP--AKGDKNCptIIHFVLANINFRNFKAP--GVPRDSDKDIEFGDFD 658 zebrafish
NP_014386 560 NASNTSTFKITYNQSEVSSML-----PTGRGVFSNDYDLYykNCLGCILTKRTMDRLPRkkKFSPFCLQCFKDYCYS 631 Saccharomyces cerevis...
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