Npr2 natriuretic peptide receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npr2provided by MGI
Official Full Name: natriuretic peptide receptor 2provided by MGI
Primary source: MGI:MGI:97372
See related: Ensembl:ENSMUSG00000028469 AllianceGenome:MGI:97372
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: cn; pwe; GC-B; GC-B2; GC-B3; mNPR-B
Summary: Enables guanylate cyclase activity; identical protein binding activity; and natriuretic peptide receptor activity. Acts upstream of or within several processes, including bone development; negative regulation of meiotic cell cycle; and negative regulation of oocyte maturation. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Used to study achondroplasia; acromesomelic dysplasia, Maroteaux type; and bone development disease. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 38.6), lung adult (RPKM 29.1) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 23.05 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (43629015..43651437)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (43629015..43651437)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclasedagger.
Title: Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclase†.
Natriuretic peptide receptor B maintains heart rate and sinoatrial node function via cyclic GMP-mediated signalling.
Title: Natriuretic peptide receptor B maintains heart rate and sinoatrial node function via cyclic GMP-mediated signalling.
Prevention of guanylyl cyclase-B dephosphorylation rescues achondroplastic dwarfism.
Title: Prevention of guanylyl cyclase-B dephosphorylation rescues achondroplastic dwarfism.
Cyclic AMP links luteinizing hormone signaling to dephosphorylation and inactivation of the NPR2 guanylyl cyclase in ovarian folliclesdagger.
Title: Cyclic AMP links luteinizing hormone signaling to dephosphorylation and inactivation of the NPR2 guanylyl cyclase in ovarian follicles†.
Defective development and microcirculation of intestine in Npr2 mutant mice.
Title: Defective development and microcirculation of intestine in Npr2 mutant mice.
Natriuretic Peptide Receptor 2 Locus Contributes to Carotid Remodeling.
Title: Natriuretic Peptide Receptor 2 Locus Contributes to Carotid Remodeling.
Cellular Heterogeneity of the Luteinizing Hormone Receptor and Its Significance for Cyclic GMP Signaling in Mouse Preovulatory Follicles.
Title: Cellular Heterogeneity of the Luteinizing Hormone Receptor and Its Significance for Cyclic GMP Signaling in Mouse Preovulatory Follicles.
Npr2 may play an important role in early embryonic development and embryo implantation
Title: Expression and localization of Npr2 in mouse oocytes and pre-implantation embryos.
Phosphorylation of specific serine and threonine residues in juxtamembrane regions of Npr2 are required for its enzymatic activity and for axon bifurcation.
Title: Regulation of the Natriuretic Peptide Receptor 2 (Npr2) by Phosphorylation of Juxtamembrane Serine and Threonine Residues Is Essential for Bifurcation of Sensory Axons.
Myofibrogenesis in cultured Npr2(+/)(-) fibroblasts was insensitive to CNP treatment. Aged Npr2(+/)(-) and Npr2(+/)(-);Ldlr-/- mice developed cardiac dysfunction and ventricular fibrosis. Aortic valve function was impaired in Npr2(+/)(-) and Npr2(+/)(-);Ldlr(-/)(-) mice, with increased valve thickening, myofibrogenesis, osteogenesis, proteoglycan synthesis, collagen accumulation and calcification.
Title: Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Associated conditions

Description	Tests
achondroplasia GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Spontaneous (5) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Npr2 (e-PCR), detects polymorphism
- UniSTS:526955

Npr2 (e-PCR), detects polymorphism
- UniSTS:525462

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables guanylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables natriuretic peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables natriuretic peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables natriuretic peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables phosphorus-oxygen lyase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of meiosis involved in egg activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis involved in innervation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood circulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in c-di-GMP signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cGMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cGMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cGMP metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cGMP	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to peptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cumulus cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endochondral ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastric emptying	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth plate cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in limb development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle process involved in oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organismal reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ossification	IEA Inferred from Electronic Annotation more info
involved_in ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor guanylyl cyclase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in renal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to fibroblast growth factor	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hormone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to luteinizing hormone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to salt	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in startle response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuole organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vestibulocochlear nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vestibulocochlear nerve maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in white fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: atrial natriuretic peptide receptor 2

Names: ANP-B; ANPR-B; NPR-B; Nppb receptor; atrial natriuretic peptide receptor type B; guanylate cyclase B; guanylyl cyclase-B; natriuretic peptide receptor B type

NP_001342395.1

EC 4.6.1.2

NP_776149.1

EC 4.6.1.2

XP_036019883.1

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355466.1 → NP_001342395.1 atrial natriuretic peptide receptor 2 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.

Source sequence(s)

AL732626, BE646739, BF469229, CB246804, CJ065677, CK623561, CK624702, CN529877, CO425573, EH106384

UniProtKB/TrEMBL

B1AWI7

Conserved Domains (4) summary

smart00044
Location:800 → 984

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14042
Location:486 → 767

PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B

pfam07701
Location:773 → 821

HNOBA; Heme NO binding associated

cd06384
Location:26 → 421

PBP1_NPR_B; ligand-binding domain of type B natriuretic peptide receptor
NM_173788.4 → NP_776149.1 atrial natriuretic peptide receptor 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_776149.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL732626, BE646739, BF469229, CB246804, CK623561, CK624702, CN529877, CO425573, EH106384

Consensus CDS

CCDS18105.1

UniProtKB/Swiss-Prot

B1AWI8, Q6VVW3, Q6VVW4, Q6VVW5, Q8CGA9

UniProtKB/TrEMBL

B1AWI7

Related

ENSMUSP00000030191.9, ENSMUST00000030191.15

Conserved Domains (4) summary

smart00044
Location:825 → 1009

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14042
Location:518 → 792

PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B

pfam07701
Location:798 → 846

HNOBA; Heme NO binding associated

cd06384
Location:26 → 421

PBP1_NPR_B; ligand-binding domain of type B natriuretic peptide receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

43629015..43651437

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163990.1 → XP_036019883.1 atrial natriuretic peptide receptor 2 isoform X1

UniProtKB/TrEMBL

F6YT88

Related

ENSMUSP00000114385.2, ENSMUST00000128549.3

Conserved Domains (3) summary

smart00044
Location:357 → 541

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14042
Location:50 → 324

PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B

pfam07701
Location:330 → 378

HNOBA; Heme NO binding associated