Conserved Protein Domain Family
HNOBA
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pfam07701: HNOBA (this model, PSSM-Id:369471 is obsolete and has been replaced by 462234)
Heme NO binding associated
The HNOBA domain is found associated with the HNOB domain and pfam00211 in soluble cyclases and signalling proteins. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce diverse downstream signals, in both bacteria and animals.
Links
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Statistics
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PSSM-Id: 369471
Aligned: 68 rows
Threshold Bit Score: 165.817
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDO40401      230 KSMPLENFFNIFPFSFVISANMRISMAGHSLLSILg--KELLGAKVTDAFTLRRPKTEFTWENLQVWRAA-FELVSNLPS 306  starlet sea a...
EDO47083      309 PKISPATFCKAFPFHLMFNRDLKVTQAGESVSRVVp-sLTPGDADMSEIFELIRPQLRFTYEAIIAHINTvFVLRTREGK 387  starlet sea a...
EFX89313      226 PKISSQLFCRAFPFHVLFDRNLSIKQVGDSLKRILpasINRSGCKLTDILRMVRPHMELSFENLLAHINTvYILVTKEKK 305  common water ...
EDO47084      215 SRIGTAAFCRACPFHAVFDQRMVIYQAGISLCRVLp-aVRVGKSKLTDIFESIRPPIKLTFDNILQYINKvYVIKTKSGL 293  starlet sea a...
EKC42091      206 KKISPATFCRAFPFHFMYDRNMVIRQAGSSLQRVIp-qTGSPTCRVDSVFEMVRPHMDFEFNNVLSHINTvYVLRTQAGV 284  Pacific oyster
ETE64349      885 SRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLp-qLQPGYCNLLSVFSLVRPHIDISFHGILSHINTvFVLRSKEGL 963  king cobra
EDO47086      226 REMNLLSFCKAFPFHVMFDRKLHIKQAGLSLTRIMtkqKLNDTLKFTDLFRISRPRMEFSFQAVISHINTvFVVTTKAGA 305  starlet sea a...
EEN67604      346 LPLSVDTFNDIFPFHVMLDRDLKVVQMGRSLKRLLksnVTSAELRFQDIFEIIRPKVESLFSDIVRHLNTiYVVRTVQGI 425  Florida lancelet
PNI44770      318 LRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLr-cDTHKVLKFEDCFEIVSPKVNATFERVLLRLSTpFVIRTKPEA 396  chimpanzee
XP_003977131  378 LRIGLATFCCAFPFHLVLGPRMELLQLGEGLRRQAr-iDPHRSVLFRECFEIISPKMEPSFQGILLRLASpFTIRTRPDA 456  torafugu

EDO40401      307 IVETGAVRNIEKlqasyhqartdfkrkkrldsnfngvqnkennfgyenripgrakelswikvdhrssgfgahglpiadak 386  starlet sea a...
EDO47083      388 LSKPANNMCNKNgcck---------------------------------------------------------------- 403  starlet sea a...
EFX89313      306 SDQSPDKAVPSLatwrhhe------------------------------------------------------------- 324  common water ...
EDO47084      294 LDSASLSTVSEDdyg----------------------------------------------------------------- 308  starlet sea a...
EKC42091      285 LDSDGLYIHTNIae------------------------------------------------------------------ 298  Pacific oyster
ETE64349      964 LDVEKLECEDELtg------------------------------------------------------------------ 977  king cobra
EDO47086      306 VQLPDNIESTD--------------------------------------------------------------------- 316  starlet sea a...
EEN67604      426 INKGKDCTAQACegasns-------------------------------------------------------------- 443  Florida lancelet
PNI44770      397 SGSENKDK-SKHvteghltq------------------------------------------------------------ 415  chimpanzee
XP_003977131  457 TQAGTKEK------------------------------------------------------------------------ 464  torafugu

EDO40401      387 esrttkrqetaknppeevrqakksekvgilsrvvdnlrcipmlidedgeevkdvaskngkrenksgfimsacdtvitted 466  starlet sea a...
EDO47083          --------------------------------------------------------------------------------      starlet sea a...
EFX89313          --------------------------------------------------------------------------------      common water ...
EDO47084          --------------------------------------------------------------------------------      starlet sea a...
EKC42091          --------------------------------------------------------------------------------      Pacific oyster
ETE64349          --------------------------------------------------------------------------------      king cobra
EDO47086          --------------------------------------------------------------------------------      starlet sea a...
EEN67604          --------------------------------------------------------------------------------      Florida lancelet
PNI44770          --------------------------------------------------------------------------------      chimpanzee
XP_003977131      --------------------------------------------------------------------------------      torafugu

EDO40401      467 gvmlrngsttfvrddcdgndmyidtinkdvvwvkqtphirpsnarkyykspgthpverterlcrhknsnartyiqnqeks 546  starlet sea a...
EDO47083          --------------------------------------------------------------------------------      starlet sea a...
EFX89313          --------------------------------------------------------------------------------      common water ...
EDO47084          --------------------------------------------------------------------------------      starlet sea a...
EKC42091          --------------------------------------------------------------------------------      Pacific oyster
ETE64349          --------------------------------------------------------------------------------      king cobra
EDO47086          --------------------------------------------------------------------------------      starlet sea a...
EEN67604          --------------------------------------------------------------------------------      Florida lancelet
PNI44770          --------------------------------------------------------------------------------      chimpanzee
XP_003977131      --------------------------------------------------------------------------------      torafugu

EDO40401      547 dkevcdslseeesdgvtvslpspskrrdsiysdspqdnvkKQPRIHLKGEMKYIKQNNKVLFVCSPVIGGFNEMMRCGVY 626  starlet sea a...
EDO47083      404 -------------------------------------lcwDSLPLRLKGQMVYIPESDNMIFLCSPSVGNLEDLADVGLY 446  starlet sea a...
EFX89313      325 ----------------------------------dgteiiQEANLRLKGEMIYVQENGLMLFLGSPSVLNLEDLTRRGLY 370  common water ...
EDO47084      309 --------------------------------------nlESPSMRFRGQMMYLPECNSIMFLASPSVVNLDGLNEKGLY 350  starlet sea a...
EKC42091      299 --------------------------------------qnDISRMRLKGQMIYVPESDMMLFLCSPSVTNLDDLHRKGLY 340  Pacific oyster
ETE64349      978 ---------------------------------------tEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLY 1018 king cobra
EDO47086      317 ------------------------------------------ASLRLKGQMLYVPDSDCLLFLCSPRVKNMDSLREKGLY 354  starlet sea a...
EEN67604      444 -----------------------------------asvdvEESTLRLKGEMVFVTESDMLLFLCSPRVKDLSEFLRKGLY 488  Florida lancelet
PNI44770      416 ---------------------------------lsvagfnSLEVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLH 462  chimpanzee
XP_003977131  465 -------------------------------------------VMELKGQMIHVPESCSLMFLGSPRVDKLEELMGRGLY 501  torafugu

EDO40401      627 MSDLGMHDRSQEMVLSGIQPLQQLEYARdQLLEKSRELEKNMKRVERERMRSNQLLYQMIPKQIADRL 694  starlet sea anemone
EDO47083      447 LSDIPLHDATKDLILLSEQFKAEYVLTQ-QLEILTDKLRQTHNALAEKKQLTDQLLYSVLPPSVANEL 513  starlet sea anemone
EFX89313      371 LSDIPLHDATRDLVLLSEQFEAEYKLTR-DLEMLTDQLQQTKVELEREKQKTDTLLYSVLPPSVANEL 437  common water flea
EDO47084      351 MSDIPIHDATRDLILLSEQHNAEFKLSQ-RLEILTDKLQQTSRELENEQQLNDRLLYSILPASVANDL 417  starlet sea anemone
EKC42091      341 LSDIPLHDATRDLVLLSERFEADYKLAR-NLEVLNDQLQQTHRELEDEKAKTDRLMYSILPISVANEL 407  Pacific oyster
ETE64349     1019 LSDIPLHDATRDLVLLGEQFREEYKLTQ-ELEILTDRLQHTLRALEDEKKKTDTLLYSVLPPSVANEL 1085 king cobra
EDO47086      355 FSDIPVHDATRDLLFLSHARRAERELVE-KLEETSNNLKKVESKLIEHKKRTDDLLYSILPKEVAAKL 421  starlet sea anemone
EEN67604      489 FSDTPLHDSSRDVLMVNYLRRRERDLLD-KIEDVGNQLRKLQGRLSEDKRRTEELLHSILPSNAVQsl 555  Florida lancelet
PNI44770      463 LSDIPIHDATRDVILVGEQAKAQDGLKK-RMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAqql 529  chimpanzee
XP_003977131  502 LSDIPIHDATRDVILVGEQARAQDGLKK-RMDKLKATLERTHQALEEEKRRTVDLLYSIFPGDVAQKL 568  torafugu
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